combigel 10% gel
What is combigel 10% gel used for?
Adol 200mg Tablet (Ibuprofen) is used to treat PAIN ANALGESICS. It contains Ibuprofen (10% w/w), which Reversibly inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme. Always consult your doctor before use. Take as prescribed.
- Generic Name: Ibuprofen
- Manufacturer: Biodyne Remedies Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ combigel 10% gel Uses & Benefits
Mild to moderate pain (headache, dental pain, dysmenorrhea, musculoskeletal pain), fever, inflammation (rheumatoid arthritis, osteoarthritis).
Off-label uses: Patent ductus arteriosus closure in neonates, Prevention of heterotopic ossification, Alzheimer's disease (investigational)
๐ Drug Information
| Generic Name(s) | Ibuprofen |
| Brand Name | Adol 200mg Tablet |
| Manufacturer | Biodyne Remedies Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID's- Non-Selective COX 1&2 Inhibitors (propionic acid) |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC) in a dry place, away from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Reversibly inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, reducing synthesis of prostaglandins, prostacyclin, and thromboxanes.
Mechanism Steps
๐ก How to Take combigel 10% gel
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of combigel 10% gel
โ Common Side Effects
- Nausea
- Dyspepsia
- Heartburn
- Diarrhea
- Constipation
- Headache
- Dizziness
- Rash
๐จ Serious Side Effects
- Gastrointestinal bleeding
- Peptic ulcer
- Renal failure
- Hypertension
- Heart failure
- Anaphylaxis
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Aseptic meningitis
- Hepatitis
- Pancreatitis
- Agranulocytosis
- Thrombocytopenia
- Visual disturbances
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Aspirin | Major | Increased risk of gastrointestinal ulceration and bleeding |
| Methotrexate | Major | Increased methotrexate toxicity |
| Lithium | Major | Increased lithium levels and toxicity |
| ACE inhibitors | Major | Reduced antihypertensive effect and increased risk of renal impairment |
| Diuretics | Moderate | Reduced diuretic effect and increased risk of renal impairment |
| Antihypertensives | Moderate | Reduced antihypertensive effect |
| SSRIs | Moderate | Increased risk of gastrointestinal bleeding |
| Corticosteroids | Moderate | Increased risk of gastrointestinal ulceration |
| Digoxin | Moderate | Increased digoxin levels |
| Antacids | Minor | Reduced absorption of ibuprofen |
| Caffeine | Minor | Additive stimulant effects |
| Alcohol | Minor | Increased risk of gastrointestinal irritation |
๐จ Major Interactions
- Aspirin
- Warfarin
- Methotrexate
- Lithium
- ACE inhibitors
โก Moderate Interactions
- Diuretics
- Antihypertensives
- SSRIs
- Corticosteroids
- Digoxin
โน๏ธ Minor Interactions
- Antacids
- Caffeine
- Alcohol
๐ฝ๏ธ Food Interactions
Food may delay absorption but does not significantly affect bioavailability.
๐ท Alcohol Interaction
Increased risk of gastrointestinal bleeding and ulceration.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
History of hypersensitivity to ibuprofen or other NSAIDs; active peptic ulcer disease; severe heart failure; third trimester of pregnancy; history of asthma exacerbated by NSAIDs; severe renal or hepatic impairment.
๐ Monitoring Parameters
Renal function, liver function, blood pressure, signs of gastrointestinal bleeding, and symptoms of hypersensitivity.
๐คฑ Lactation Safety
Compatible; small amounts excreted in breast milk, but considered safe with caution.
๐ Overdose Management
Induce emesis or gastric lavage; administer activated charcoal; supportive care; monitor for metabolic acidosis, renal failure, and gastrointestinal bleeding.
โฐ Missed Dose
Take as soon as remembered unless almost time for next dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Found this to be a helpful product. Good results.
Found this to be a helpful product. Good results.
Found this to be a helpful product. Good results.
This medicine was effective for me. I followed the doctor's advice.
This medicine was effective for me. I followed the doctor's advice.