Azicef-LB Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe or persistent diarrhea, or blood in stool
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
- Palpitations, dizziness, or fainting
- Unusual bleeding or bruising
- Severe skin rash with blisters or peeling
- Decreased urine output or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is colxime-az tablet used for?
This medicine is a combination antibiotic containing Cefixime 200 mg and Azithromycin 250 mg. It is used to treat various bacterial infections. It works by killing bacteria through two different mechanisms. It should only be taken when prescribed by a doctor, and the full course must be completed.
- Generic Name: Cefixime + Azithromycin
- Manufacturer: Colard Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 colxime-az tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सेफिक्सिम 200 मिलीग्राम और एज़िथ्रोमाइसिन 250 मिलीग्राम का संयोजन है, जिसका उपयोग विभिन्न जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह श्वसन तंत्र के संक्रमण, मूत्र मार्ग के संक्रमण, त्वचा के संक्रमण और टाइफाइड बुखार में प्रभावी है। यह दवा केवल डॉक्टर के पर्चे पर ही लेनी चाहिए और पूरा कोर्स पूरा करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, पेट दर्द, सिरदर्द और उल्टी शामिल हैं। कुछ रोगियों में त्वचा पर चकत्ते या खुजली हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें एलर्जी, लीवर की समस्या, और दिल की धड़कन में अनियमितता शामिल हो सकती है। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। कोर्स पूरा करें, बीच में न छोड़ें। दवा को पानी के साथ लें, खाने के साथ या बिना खाने के। एंटासिड के साथ 2 घंटे का अंतराल रखें। गुर्दे या लीवर की बीमारी हो तो डॉक्टर को बताएं। शराब न लें। दवा को ठंडी और सूखी जगह पर रखें। बच्चों से दूर रखें।
💊 colxime-az tablet Uses & Benefits
- [{"condition":"Community-acquired pneumonia","description":"Used when a clinician determines that dual antibiotic coverage is appropriate for moderate to severe cases.","evidence":"Well-established for individual components; combination use is based on clinical judgment."},{"condition":"Acute bacterial exacerbation of chronic bronchitis","description":"May be prescribed to cover common respiratory pathogens including Streptococcus pneumoniae and Haemophilus influenzae.","evidence":"Well-established for individual components."},{"condition":"Urinary tract infections","description":"Cefixime component is effective against many uropathogens; azithromycin adds coverage for atypical organisms.","evidence":"Well-established for cefixime; azithromycin is not first-line for UTI."},{"condition":"Skin and soft tissue infections","description":"May be used for uncomplicated infections when both gram-positive and gram-negative coverage is desired.","evidence":"Limited for combination; individual agents have established roles."},{"condition":"Typhoid fever","description":"Cefixime is used for enteric fever; azithromycin is an alternative.
- Combination may be used in some regions.","evidence":"Limited for combination; individual agents are established."}]
Off-label uses: [{"condition":"Lyme disease","description":"Azithromycin has been used off-label for early Lyme disease, but not routinely recommended.","evidence":"Limited"},{"condition":"Mycobacterium avium complex prophylaxis","description":"Azithromycin is used off-label for prophylaxis in advanced HIV, but not in combination with cefixime.","evidence":"Well-established for azithromycin alone."}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Skin infections, Typhoid fever
📋 Drug Information
| Generic Name(s) | Cefixime + Azithromycin |
| Brand Name | Azicef-LB Tablet |
| Manufacturer | Colard Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin antibiotic + Macrolide antibiotic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container. Do not refrigerate unless specified by the manufacturer. |
| Shelf Life | Typically 24 months from the date of manufacture. Check the expiry date on the packaging. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information for this specific combination. Individual components have WHO guidelines for specific infections. |
| ICMR Guideline | Not established from the available information for this specific combination. ICMR guidelines may recommend individual antibiotics for specific conditions. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antibiotics with distinct mechanisms. Cefixime, a third-generation cephalosporin, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to inhibition of peptidoglycan cross-linking and bacterial lysis. Azithromycin, a macrolide, binds to the 50S ribosomal subunit of susceptible bacteria, inhibiting transpeptidation and translocation steps of protein synthesis, thereby blocking bacterial growth. The combination provides broad-spectrum coverage against many gram-positive and gram-negative bacteria, as well as atypical pathogens.
Mechanism Steps
💡 How to Take colxime-az tablet
Strength: Immediate-release tablet containing Cefixime 200 mg and Azithromycin 250 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this combination is one tablet taken orally once or twice daily, depending on the severity of the infection and the prescribing doctor's judgment. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-medicate. Complete the full course as prescribed, even if you feel better after a few days. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced renal function and should be monitored closely. Dose adjustment of cefixime may be necessary based on creatinine clearance. Azithromycin does not require dose adjustment in the elderly, but caution is advised due to potential for QT prolongation and drug interactions. |
| Renal Impairment | In patients with renal impairment, cefixime dose should be adjusted based on creatinine clearance. For creatinine clearance 20-40 mL/min, a reduced dose is recommended. For creatinine clearance less than 20 mL/min, further dose reduction or alternative therapy may be needed. Azithromycin does not require renal dose adjustment. Consult a clinician for individualized dosing. |
| Hepatic Impairment | No specific dose adjustment is established for cefixime in hepatic impairment. Azithromycin should be used with caution in patients with hepatic impairment due to risk of hepatotoxicity. Monitor liver function. Consult a clinician for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose of this combination is not established from available information. Dosing must be determined by a qualified clinician based on the specific clinical situation. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of colxime-az tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ergotamine | Major | |
| Amiodarone | Major | |
| Antacids | Moderate | |
| Carbamazepine | Moderate | |
| Digoxin | Moderate | |
| Cyclosporine | Moderate | |
| Oral contraceptives | Minor | |
| Probenecid | Minor |
🚨 Major Interactions
- Warfarin
- Ergot alkaloids (e.g., ergotamine)
- QT-prolonging drugs (e.g., amiodarone, sotalol)
⚡ Moderate Interactions
- Antacids (aluminum/magnesium)
- Carbamazepine
- Digoxin
- Cyclosporine
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Both cefixime and azithromycin can potentially cause liver enzyme elevations, and alcohol may increase the risk of liver-related side effects. Additionally, alcohol can worsen gastrointestinal side effects such as nausea and diarrhea. It is best to abstain from alcohol until the course is completed and you have recovered.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to cefixime, other cephalosporins, or azithromycin","History of cholestatic jaundice or hepatic dysfunction associated with prior azithromycin use","Concomitant use with ergot alkaloids","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["Serious allergic reactions, including anaphylaxis, can occur. Discontinue immediately if allergic reaction suspected.","Clostridioides difficile-associated diarrhea can occur. If severe diarrhea develops, discontinue and seek medical advice.","QT prolongation and arrhythmias: Use with caution in patients with cardiac disease or electrolyte abnormalities.","Hepatotoxicity: Monitor liver function if symptoms of liver injury occur.","Superinfection: Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","Renal impairment: Dose adjustment of cefixime is required.","Not effective against viral infections. Do not use for colds or flu."]
🤱 Lactation Safety
Cefixime is excreted in breast milk in low amounts and is generally considered compatible with breastfeeding. Azithromycin is also excreted in breast milk and is considered compatible. However, consult your doctor before use, as the infant should be monitored for diarrhea or thrush.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, diarrhea, and abdominal pain. In case of overdose, seek immediate medical attention. Treatment is symptomatic and supportive. There is no specific antidote. Hemodialysis may be considered for cefixime overdose, but not for azithromycin. Monitor vital signs and electrolytes.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. Try to take the missed dose within a few hours of the scheduled time to maintain effective blood levels.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop the course early, even if you feel better, as this can lead to antibiotic resistance and recurrence of infection. Take the tablet with a full glass of water, with or without food, but if you experience stomach upset, take it with a meal. Avoid taking antacids containing aluminum or magnesium within two hours of this medicine, as they can reduce absorption of cefixime. Inform your doctor if you have kidney or liver problems, as dose adjustments may be needed. Do not share this medicine with others. Avoid alcohol while taking this medicine to reduce the risk of liver-related side effects. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Store this medicine at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney function and are at higher risk of side effects. Dose adjustment of cefixime may be needed based on renal function. Monitor for signs of QT prolongation and drug interactions. Ensure adequate hydration.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Both components are generally considered safe in pregnancy, but the decision to use this medicine should be made by your doctor based on the risks and benefits.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon that you are taking this medicine. It may interact with anesthetics or other medications used during surgery. Your doctor may advise you to stop the medicine temporarily before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. Antibiotics may affect the oral flora and increase the risk of fungal infections in the mouth. Your dentist may recommend additional precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel tired or dizzy. Avoid strenuous exercise until you feel fully recovered. Light activities like walking are fine if you feel up to it. Listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people. If you experience these effects, avoid driving or operating heavy machinery. Most people can continue their normal daily activities, but take it easy until you feel better. Stay home if you have a fever or are feeling unwell to prevent spreading infection.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Complete the full prescribed course, even if you feel better. If you experience severe side effects, contact your doctor immediately; they may advise you to stop or change the medicine.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended unless prescribed by a doctor for a specific chronic infection. Prolonged use can lead to antibiotic resistance, superinfection with fungi or resistant bacteria, and rare liver or kidney toxicity. Regular monitoring of liver and kidney function may be required if prolonged therapy is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection, a single antibiotic may be sufficient and reduce the risk of side effects.
Evidence: Well-establishedRest, fluids, and symptomatic treatment can help while the body fights mild infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics do not interact with vaccines. However, if you are scheduled to receive a live vaccine, inform your doctor, as antibiotics may affect the immune response to certain vaccines. Generally, there is no need to delay vaccination due to antibiotic use.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking the medicine at the same intervals as prescribed; consult your doctor for specific advice. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but it is important to complete the full course as prescribed.
A: Yes, you can take it with or without food. If you experience stomach upset, take it with a meal.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Both components are generally considered safe in pregnancy, but you should consult your doctor before taking any medicine.
A: It is best to avoid alcohol as it may increase the risk of liver-related side effects and worsen gastrointestinal symptoms.
🤔 Common Patient Concerns
🔄 Substitutes for colxime-az tablet
View AllAlternative brands with exact same active ingredient:
-
cefivot az kid tabletVotary Laboratories I Ltd ₹92.81 59.9% CHEAPER
-
ceficheck az 200mg/250mg tabletHilbert Healthcare ₹92.81 59.9% CHEAPER
-
aelxim-az 200mg/250mg tabletAllenge India ₹93.38 59.7% CHEAPER
-
Setxim AZ 200mg/250mg TabletAtyad Life Sciences Pvt Ltd ₹99.00 57.2% CHEAPER
-
zytax-az 200mg/250mg tabletZodley Pharmaceuticals Pvt Ltd ₹99.60 57% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure viral infections like the common cold.
Fact: This medicine is effective only against bacterial infections. It does not treat viral infections. - Myth: You can stop taking antibiotics once you feel better.
Fact: You must complete the full prescribed course to prevent recurrence and antibiotic resistance. - Myth: Antibiotics can be shared with family members.
Fact: Never share antibiotics. They are prescribed for a specific infection and person.
🔄 Alternative Options
Generic Alternatives
- Cefixime 200 mg + Azithromycin 250 mg tablet (generic)
Brand Alternatives
- Azicef-LB Tablet