colfin oral drops - Chlorpheniramine Maleate (2mg/5ml) + Phenylephrine (5mg/5ml) medicine

colfin oral drops

4.5 (15 reviews)
๐Ÿญ Chethana Pharmaceuticals ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is colfin oral drops used for?

Ascoril Flu Syrup (Chlorpheniramine Maleate + Phenylephrine) is used to treat RESPIRATORY. It contains Chlorpheniramine Maleate (2mg/5ml) + Phenylephrine (5mg/5ml), which Chlorpheniramine blocks histamine H1 receptors; Phenylephrine stimulates alpha-1. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Chlorpheniramine Maleate + Phenylephrine
  • Manufacturer: Chethana Pharmaceuticals
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š colfin oral drops Uses & Benefits

Symptomatic relief of common cold, allergic rhinitis, sinusitis

Off-label uses: Not commonly used off-label

๐Ÿ“‹ Drug Information

Generic Name(s)Chlorpheniramine Maleate + Phenylephrine
Brand NameAscoril Flu Syrup
ManufacturerChethana Pharmaceuticals
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAntihistamine + Decongestant
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light and moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed orally
DistributionDistributed throughout body; crosses blood-brain barrier
Protein BindingChlorpheniramine: ~70%; Phenylephrine: low
MetabolismHepatic via CYP450
Half-LifeChlorpheniramine: 21-27 hours; Phenylephrine: 2-3 hours
ExcretionRenal (urine)
BioavailabilityChlorpheniramine: ~50%; Phenylephrine: ~38%
Onset of Action15-30 minutes
Peak Plasma TimeChlorpheniramine: 2-6 hours; Phenylephrine: 1-2 hours
Duration of Action4-6 hours

How It Works

Chlorpheniramine blocks histamine H1 receptors; Phenylephrine stimulates alpha-1 adrenergic receptors causing vasoconstriction

Mechanism Steps

1Chlorpheniramine competitively blocks H1 receptors, preventing histamine-mediated effects such as vasodilation, increased capillary permeability, and bronchoconstriction.
2Phenylephrine selectively stimulates alpha-1 adrenergic receptors on vascular smooth muscle, causing vasoconstriction in nasal mucosa, reducing swelling and congestion.
3Combined action reduces symptoms of allergic rhinitis and common cold.

๐Ÿ’ก How to Take colfin oral drops

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of colfin oral drops

โœ… Common Side Effects

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Nausea
  • Headache
  • Insomnia

๐Ÿšจ Serious Side Effects

  • Hypertension
  • Arrhythmias
  • Seizures
  • Urinary retention
  • Hallucinations

โš ๏ธ Rare Side Effects

  • Blood dyscrasias
  • Anaphylaxis
  • Hepatotoxicity

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
MAOIs Major Hypertensive crisis
Beta-blockers Major Reduced efficacy of both drugs
Tricyclic antidepressants Major Increased risk of hypertension and arrhythmias
Antihypertensives Moderate Reduced antihypertensive effect
CNS depressants Moderate Increased sedation
Sympathomimetics Moderate Additive pressor effects
Anticholinergics Minor Additive anticholinergic effects
Digoxin Minor Possible increased digoxin toxicity

๐Ÿšจ Major Interactions

  • MAOIs
  • Beta-blockers
  • Tricyclic antidepressants

โšก Moderate Interactions

  • Antihypertensives
  • CNS depressants
  • Sympathomimetics

โ„น๏ธ Minor Interactions

  • Anticholinergics
  • Digoxin

๐Ÿฝ๏ธ Food Interactions

Avoid alcohol; may increase CNS depression

๐Ÿท Alcohol Interaction

Increased sedation and CNS depression

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity, severe hypertension, coronary artery disease, MAOI use within 14 days, narrow-angle glaucoma, urinary retention

๐Ÿ“Š Monitoring Parameters

Blood pressure, heart rate, CNS effects, urinary output

๐Ÿคฑ Lactation Safety

Use with caution; may be excreted in breast milk

๐Ÿ’Š Overdose Management

Symptomatic and supportive; consider activated charcoal, monitor vitals, treat arrhythmias if needed

โฐ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

โญ User Reviews

Verified User Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Regular Customer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

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