cofspin syrup - Ambroxol (NA) + Guaifenesin (NA) medicine

Ambromak T Suspension: Complete Guide to Uses, Dosage, and Safety

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🏭 Cerspin Healthcare Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 25, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for approved uses; limited for off-label uses.
Reviewed by
SaathiMed Expert Panel | Oct 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or shortness of breath
  • Swelling of the face, lips, tongue, or throat
  • Severe rash, blisters, or peeling skin
  • Blood in vomit or black, tarry stools
  • Yellowing of the skin or eyes
  • Severe abdominal pain
  • High fever with cough lasting more than 3 days
  • Cough lasting more than 7 days without improvement

If experiencing severe symptoms, call emergency services immediately.

What is cofspin syrup used for?

This medicine is a combination of ambroxol and guaifenesin used to treat productive cough with thick mucus. It works by thinning mucus and making it easier to cough up. It is usually taken 2-3 times a day for up to 7 days. Always follow your doctor's instructions.

  • Generic Name: Ambroxol + Guaifenesin
  • Manufacturer: Cerspin Healthcare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 cofspin syrup के बारे में (Hindi Summary)

उपयोग: यह दवा बलगम वाली खांसी और छाती में जमा कफ को साफ करने के लिए इस्तेमाल की जाती है। इसमें एम्ब्रोक्सोल और गुआइफेनेसिन दो सक्रिय तत्व होते हैं जो बलगम को पतला करके बाहर निकालने में मदद करते हैं। यह तीव्र और दीर्घकालिक ब्रोंकाइटिस, और सर्दी-जुकाम से जुड़ी खांसी में राहत देती है। यह दवा सूखी खांसी के लिए नहीं है। इसे डॉक्टर के बताए अनुसार ही लें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, दस्त, पेट दर्द, नींद आना, चक्कर आना और मुंह सूखना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या त्वचा पर गंभीर दाने हो सकते हैं। अगर ऐसा कुछ हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे खाने के साथ या बिना खाने के ले सकते हैं, लेकिन पेट खराब होने पर खाने के साथ लें। गाड़ी चलाने या मशीन चलाने से बचें अगर नींद या चक्कर आए। शराब न पिएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। 7 दिन से ज्यादा इस्तेमाल न करें। बच्चों को डॉक्टर की सलाह के बिना न दें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 cofspin syrup Uses & Benefits

[{"condition":"Productive cough with thick mucus","description":"Helps loosen and thin mucus in the airways, making it easier to cough up and clear chest congestion.","evidence":"Well-established"},{"condition":"Acute bronchitis","description":"Used as a supportive treatment to relieve cough and mucus buildup in acute bronchitis.","evidence":"Moderate"},{"condition":"Chronic bronchitis","description":"May help manage chronic mucus production and cough in chronic bronchitis, often as part of a broader treatment plan.","evidence":"Moderate"},{"condition":"Upper respiratory tract infections with mucus","description":"Sometimes used to ease cough and congestion associated with common colds and similar infections.","evidence":"Limited"}]

Off-label uses: [{"condition":"Prevention of respiratory complications after surgery","description":"Sometimes used off-label to help clear secretions in patients who have difficulty coughing after surgery.","evidence":"Limited"},{"condition":"Chronic obstructive pulmonary disease (COPD) with mucus","description":"May be used off-label to help with mucus clearance in some patients with COPD, but it is not a primary treatment.","evidence":"Limited"}]

Primary treatment for: Productive cough with thick mucus

Also treats: Acute bronchitis, Chronic bronchitis, Upper respiratory tract infections with mucus

📋 Drug Information

Generic Name(s)Ambroxol + Guaifenesin
Brand NameAmbrolite-S Expectorant
ManufacturerCerspin Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassMucolytic and Expectorant
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Do not freeze. Keep the bottle tightly closed when not in use.
Shelf Life24 months from the date of manufacture. Do not use after the expiry date printed on the pack.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always shake the bottle well before measuring the dose to ensure the medicine is evenly mixed.
2
Use the measuring cup provided with the medicine, not a kitchen spoon, to get the correct dose.
3
Take this medicine with food or milk if it upsets your stomach.
4
Encourage the patient to drink plenty of fluids to help thin mucus further.
5
Do not use this medicine for more than 7 days without consulting a doctor.
6
Avoid giving this medicine to children under 2 years unless prescribed by a pediatrician.
7
If the patient is taking any other cough medicine, check with a doctor to avoid harmful interactions.
8
Advise the patient to avoid alcohol while taking this medicine.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Productive cough with thick mucus
This medicine is commonly prescribed for this.
Likely Use
❌
Dry cough
This medicine is not effective for dry cough.
Not Primary
✅
Chest congestion
This medicine helps loosen mucus and clear congestion.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionBoth ambroxol and guaifenesin are absorbed from the gastrointestinal tract after oral administration. Ambroxol is rapidly absorbed, while guaifenesin is also well absorbed. Food may slightly delay the absorption of guaifenesin but does not significantly reduce the total amount absorbed.
DistributionAmbroxol is widely distributed in body tissues, including the lungs, and crosses the blood-brain barrier and placenta. Guaifenesin also distributes to various tissues. Both ingredients can pass into breast milk.
Protein BindingAmbroxol is approximately 90% bound to plasma proteins. Guaifenesin is not significantly bound to plasma proteins.
MetabolismAmbroxol is metabolized in the liver by cytochrome P450 enzymes, mainly CYP3A4, to inactive metabolites. Guaifenesin is also metabolized in the liver, primarily by oxidation, to inactive metabolites.
Half-LifeThe elimination half-life of ambroxol is approximately 7 to 12 hours. The elimination half-life of guaifenesin is approximately 1 hour.
ExcretionAmbroxol and its metabolites are mainly excreted in the urine. Guaifenesin and its metabolites are also excreted in the urine.
BioavailabilityThe oral bioavailability of ambroxol is approximately 70% to 80% due to first-pass metabolism. The oral bioavailability of guaifenesin is approximately 50% to 60%.
Onset of ActionThe onset of action for ambroxol is usually within 30 to 60 minutes after oral administration. Guaifenesin also begins to work within 30 minutes.
Peak Plasma TimeThe peak plasma concentration of ambroxol is reached approximately 1 to 3 hours after oral administration. The peak plasma concentration of guaifenesin is reached within 15 to 30 minutes.
Duration of ActionThe effects of ambroxol last for approximately 6 to 12 hours. The effects of guaifenesin last for approximately 4 to 6 hours. The suspension is usually taken 2 to 3 times a day to maintain symptom relief.

How It Works

This medicine works through two complementary mechanisms. Ambroxol increases the production of serous fluid in the airways and reduces the viscosity of mucus by breaking down acidic mucopolysaccharide fibers. It also stimulates the production of surfactant, which helps keep airways open and improves mucus transport. Guaifenesin increases the water content of mucus and reduces its stickiness, making it easier to cough up. Together, these actions thin the mucus, making coughs more productive and helping to clear the airways.

Mechanism Steps

1
Ambroxol thins mucus: Ambroxol breaks down long chains of mucopolysaccharides in mucus, reducing its thickness and stickiness.
2
Ambroxol boosts surfactant: It stimulates the production of surfactant in the lungs, which helps keep small airways open and improves mucus movement.
3
Guaifenesin adds water to mucus: Guaifenesin draws water into mucus secretions, making them less thick and easier to cough out.
4
Improved mucociliary clearance: The combined actions help the tiny hair-like structures in the airways move mucus upward so it can be coughed out.

💡 How to Take cofspin syrup

Strength: Each 5 mL of suspension contains ambroxol and guaifenesin in the strengths specified on the product label. The exact strength is not established from the available information.

1Shake the bottle well before each use.
2Use the measuring cup or spoon provided with the medicine to measure the correct dose.
3Take the medicine by mouth, with or without food.
4If it upsets your stomach, take it with a meal or a glass of milk.
5After taking, close the bottle tightly and store it as directed.
6Wash the measuring cup with water after each use.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 10 mL (two teaspoons) taken two to three times a day, or as directed by your doctor. The exact dose and duration depend on your condition, age, and other factors. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. Always use the measuring cup provided with the bottle.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician. The dose for children depends on age and weight and must be determined by a doctor. Do not give this medicine to children under 2 years of age unless prescribed by a doctor.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and dizziness. The dose may need to be adjusted based on kidney and liver function. Consult your doctor for the appropriate dose.
Renal ImpairmentPatients with kidney disease may need a lower dose or a longer interval between doses. Consult your doctor for dose adjustment.
Hepatic ImpairmentPatients with liver disease may need a lower dose or a longer interval between doses. Consult your doctor for dose adjustment.
Maximum Daily DoseThe maximum daily dose should not exceed 30 mL (6 teaspoons) in adults, unless otherwise directed by a doctor. Do not exceed the prescribed dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid large amounts
May increase drug levels.
Water
Drink plenty
Helps thin mucus and keeps you hydrated.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of cofspin syrup

✅ Common Side Effects

Nausea (Common (5-10%))
Take the medicine with food or milk to reduce stomach upset. If nausea persists, consult your doctor.
Vomiting (Common (5-10%))
Take with food and stay hydrated. If vomiting is severe or persistent, contact your doctor.
Diarrhea (Common (5-10%))
Drink plenty of fluids to avoid dehydration. If diarrhea lasts more than 2 days, consult your doctor.
Stomach pain (Common (5-10%))
Take with food. If pain is severe or does not go away, seek medical advice.
Drowsiness (Uncommon (1-5%))
Avoid driving or operating machinery until you know how this medicine affects you.
Dizziness (Uncommon (1-5%))
Sit or lie down until the dizziness passes. Avoid sudden movements. Consult your doctor if it persists.
Dry mouth (Uncommon (1-5%))
Drink water or chew sugar-free gum. If it bothers you, talk to your doctor.
Headache (Uncommon (1-5%))
Rest and stay hydrated. If headache is severe or persistent, consult your doctor.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency medical help immediately if you experience swelling of the face, lips, tongue, or throat, difficulty breathing, or a severe rash.
Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) (Very rare (<0.01%))
Stop the medicine and seek immediate medical attention if you develop a painful rash, blisters, or peeling skin.
Liver problems (hepatitis, elevated liver enzymes) (Very rare (<0.01%))
Contact your doctor if you notice yellowing of the skin or eyes, dark urine, or severe abdominal pain.
Severe stomach or intestinal bleeding (Very rare (<0.01%))
Seek immediate medical attention if you vomit blood or have black, tarry stools.

⚠️ Rare Side Effects

Kidney stones
Report severe back or side pain, painful urination, or blood in urine to your doctor immediately.
Severe low platelet count (thrombocytopenia)
Seek medical help if you notice unusual bruising or bleeding.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Codeine Major
Dextromethorphan Major
MAOIs Major
Amoxicillin Moderate
Cefuroxime Moderate
Diuretics Moderate
Lithium Moderate
Diphenhydramine Minor
Alcohol Minor
Grapefruit juice Minor

🚨 Major Interactions

  • Cough suppressants (e.g., codeine, dextromethorphan)
  • Monoamine oxidase inhibitors (MAOIs)

⚡ Moderate Interactions

  • Antibiotics (e.g., amoxicillin, cefuroxime)
  • Diuretics (water pills)
  • Lithium

🍷 Alcohol Interaction

Alcohol can increase the drowsiness and dizziness caused by this medicine. It can also worsen stomach upset. It is best to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Allergy to ambroxol, guaifenesin, or any other ingredient in this medicine","Children under 2 years of age (unless specifically prescribed by a doctor)","Severe liver disease","Severe kidney disease","Use with MAOIs"]

⚠️ Warnings & Precautions

["Do not use this medicine for a dry cough or a cough that does not produce mucus.","If your cough lasts more than 7 days, comes back, or is accompanied by fever, rash, or persistent headache, consult your doctor.","Do not take more than the recommended dose.","Avoid driving or operating machinery if you feel drowsy or dizzy.","Avoid alcohol while taking this medicine.","Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Tell your doctor if you have a history of stomach ulcers, liver disease, or kidney disease.","Keep out of reach of children.","Do not use after the expiry date.","Shake well before use."]

🤱 Lactation Safety

Ambroxol and guaifenesin may pass into breast milk. It is not known if they can affect a breastfed baby. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

If you or someone else takes too much of this medicine, seek immediate medical attention or contact a poison control center. Symptoms of overdose may include severe nausea, vomiting, diarrhea, drowsiness, and dizziness. Treatment is supportive and may include activated charcoal if taken soon after ingestion. Do not try to vomit unless instructed by a healthcare professional.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not increase the dose or take it for longer than recommended. Shake the bottle well before each use to ensure the medicine is evenly mixed. Use a proper measuring cup or spoon to get the correct dose. Do not use a kitchen spoon. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before using this medicine. Do not drive or operate heavy machinery if you feel dizzy or drowsy after taking it. Avoid drinking alcohol while taking this medicine because it can increase drowsiness and stomach upset. Keep this medicine out of the reach of children. If your cough does not improve within 7 days or gets worse, contact your doctor. Do not use this medicine to treat a dry cough or a cough that does not produce mucus. If you have a history of stomach ulcers, kidney disease, or liver disease, tell your doctor before taking this medicine.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and dizziness. They may also have reduced kidney or liver function, which can affect how the medicine is processed. The dose may need to be adjusted. Consult a doctor for appropriate dosing.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before using this medicine. There is limited information on its safety during pregnancy. Your doctor can help you weigh the benefits and risks.

🏥 Post-Surgery Considerations

If you have recently had surgery, consult your doctor before using this medicine. It may interact with other medications or affect your recovery. Your doctor will advise if it is safe for you.

🦷 Dental Procedures

This medicine does not typically affect dental procedures. However, inform your dentist that you are taking it, especially if you are scheduled for surgery or have a history of allergies.

💚 Lifestyle Tips for Better Results

🏃
Drink plenty of fluids, especially warm water, to help thin mucus.
🥗
Use a humidifier or take steamy showers to loosen chest congestion.
😴
Avoid smoking and exposure to secondhand smoke.
💧
Get plenty of rest to help your body recover.
🧘
Eat a balanced diet rich in fruits and vegetables.
🌞
Practice good hand hygiene to prevent infections.
🚭
Avoid cold drinks and ice cream if they worsen your cough.

🏋️ Exercise Considerations

If you feel dizzy or drowsy after taking this medicine, avoid exercising or doing activities that require alertness. Otherwise, light exercise like walking may be fine if you feel up to it. Listen to your body and rest when needed.

🥗 Diet Recommendations

Include warm soups and broths
Drink herbal teas with honey and lemon
Avoid cold and sugary drinks
Eat spicy foods if they help clear your sinuses
Stay hydrated with water and clear fluids

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness in some people. If you experience these effects, avoid driving, operating machinery, or doing tasks that require concentration. Otherwise, you can continue your normal activities as tolerated. Take it with food to reduce stomach upset.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your cough does not improve within 7 days, if it gets worse, or if you develop new symptoms such as fever, rash, or difficulty breathing. Also stop if you experience any severe side effects or allergic reactions.

📅 Long-Term Use Effects

This medicine is generally intended for short-term use. Long-term use should only be done under medical supervision. Prolonged use may increase the risk of side effects such as stomach upset, liver problems, or kidney problems. Your doctor may monitor your liver and kidney function if you need to use it for a long time. Do not use it for more than 7 days without consulting your doctor.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Inhaling steam can help loosen mucus and relieve chest congestion.

Evidence: Well-established
Saline nasal irrigation

Rinsing the nasal passages with saline can help clear mucus and reduce postnasal drip.

Evidence: Moderate
Honey and lemon

A warm drink with honey and lemon can soothe the throat and help with cough.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a vaccine, inform your doctor that you are taking this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✅ DO

Keep the bottle tightly closed

❌ DON'T

Do not use after the expiry date

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case customs or security asks for it. Store it in a cool, dry place away from direct sunlight. If you are crossing time zones, continue taking the medicine at the same intervals as prescribed, but adjust to local time gradually. Do not leave it in a hot car or checked luggage. If you need a refill while traveling, consult a local doctor or pharmacist.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with acute bronchitis
He had a severe wet cough with thick yellow mucus for 4 days. His doctor prescribed this medicine along with rest and fluids. Within 2 days, his cough became more productive and easier to manage. He took it with food to avoid stomach upset and completed the 5-day course as advised.
💡 Lesson: Taking this medicine as prescribed and staying hydrated helps clear mucus faster.
👤 A 60-year-old woman with chronic bronchitis
She experienced frequent episodes of chest congestion and difficulty coughing up mucus. Her doctor added this medicine to her treatment plan. She noticed that her cough became more productive and she could breathe easier. She was advised to use it only during flare-ups and to report any side effects.
💡 Lesson: This medicine can be helpful for chronic bronchitis when used under medical supervision and for the recommended duration.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30 to 60 minutes. You may notice that your cough becomes more productive and mucus is easier to cough up within a few hours. Full benefits may take 1 to 2 days.

Q: Can I take it with other cough medicines?

A: You should not take this medicine with cough suppressants like codeine or dextromethorphan, as they can prevent you from coughing up loosened mucus. Always consult your doctor before combining any medicines.

Q: Is it safe for children?

A: This medicine should only be given to children under the supervision of a doctor. The dose depends on the child's age and weight. Do not give it to children under 2 years unless prescribed.

Q: Can I take it during pregnancy?

A: There is limited information on the safety of this medicine during pregnancy. Consult your doctor before using it if you are pregnant or planning to become pregnant.

Q: What if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe for my child?
  • Can I take it with antibiotics?

🔄 Substitutes for cofspin syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure any type of cough.
    Fact: This medicine is only for productive cough with mucus. It is not effective for dry cough or cough due to allergies.
  • Myth: More medicine means faster relief.
    Fact: Taking more than the recommended dose can increase side effects and does not provide faster relief.
  • Myth: It is safe to take with any other cough syrup.
    Fact: Combining with cough suppressants can be harmful. Always consult your doctor before mixing medicines.

🔄 Alternative Options

Generic Alternatives

  • Ambroxol + Guaifenesin suspension (generic)

Brand Alternatives

  • Ambrodil-G
  • Mucolite-G
  • Cough-X
  • Bro-Zedex

📊 Comparison with Similar Medicines

[{"medicine":"This medicine (Ambroxol + Guaifenesin)","composition":"Ambroxol + Guaifenesin","uses":"Productive cough with thick mucus","notes":"Combination provides dual action: thinning and hydrating mucus."},{"medicine":"Ambroxol alone","composition":"Ambroxol","uses":"Productive cough","notes":"Only thins mucus; does not add water to mucus."},{"medicine":"Guaifenesin alone","composition":"Guaifenesin","uses":"Productive cough","notes":"Only adds water to mucus; does not break down mucus fibers."}]

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