Cofsils Cough Syrup: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Chest pain or tightness
- Coughing up blood
- High fever (above 101°F) lasting more than 3 days
- Severe headache with confusion or drowsiness
- Swelling of face, lips, or throat
- Seizures or convulsions
- Irregular or fast heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is cofryl syrup used for?
This medicine is a combination cough syrup containing diphenhydramine (an antihistamine) and ammonium chloride (an expectorant). It relieves cough, runny nose, and sneezing, but can cause drowsiness. It is for short-term use and should not be given to newborns or taken with alcohol.
- Generic Name: Diphenhydramine + Ammonium Chloride
- Manufacturer: Cipla Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cofryl syrup के बारे में (Hindi Summary)
उपयोग: यह दवा दिपhenहाइड्रामाइन और अमोनियम क्लोराइड का संयोजन है, जिसका उपयोग खांसी, जुकाम, नाक बहना, छींक आना और गले में खुजली जैसे लक्षणों से राहत के लिए किया जाता है। यह खांसी को शांत करने और बलगम को पतला करके निकालने में मदद करती है। यह दवा अल्पकालिक उपयोग के लिए है और इसे डॉक्टर की सलाह के बिना लंबे समय तक नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, धुंधली दृष्टि और पेट में हल्की गड़बड़ी शामिल हैं। कभी-कभी उल्टी, कब्ज या पेशाब में रुकावट हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, दौरे या अनियमित धड़कन हो सकती है। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर द्वारा बताई गई मात्रा और अवधि के अनुसार ही लें। शराब का सेवन बिल्कुल न करें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। दवा लेने के बाद वाहन चलाने या मशीनरी चलाने से बचें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। बच्चों को डॉक्टर की सलाह के बिना न दें। यदि खांसी 7 दिनों से अधिक रहे तो डॉक्टर से मिलें।
💊 cofryl syrup Uses & Benefits
[{"condition":"Cough associated with common cold","description":"Provides short-term relief of dry, irritating cough and associated runny nose or sneezing due to its antihistamine and expectorant actions.","evidence":"Commonly used, evidence based on established pharmacological effects"},{"condition":"Allergic cough and upper respiratory allergy symptoms","description":"Diphenhydramine helps reduce allergic rhinitis symptoms such as sneezing, runny nose, and itchy throat that can trigger cough.","evidence":"Well-established for antihistamine component"},{"condition":"Productive cough with thick mucus","description":"Ammonium chloride acts as an expectorant to help thin and loosen bronchial secretions, making cough more productive.","evidence":"Traditional use, limited modern clinical trial evidence"}]
Off-label uses: [{"condition":"Insomnia due to cough","description":"Sometimes used for its sedative effect to help sleep when cough interferes with rest, but this is not a primary approved use.","evidence":"Limited"},{"condition":"Motion sickness","description":"Diphenhydramine has antiemetic properties, but this combination is not intended for motion sickness.","evidence":"Limited"}]
Primary treatment for: Cough associated with common cold and allergic rhinitis
Also treats: Allergic rhinitis, Upper respiratory tract infection, Postnasal drip
📋 Drug Information
| Generic Name(s) | Diphenhydramine + Ammonium Chloride |
| Brand Name | Broncholyn Syrup |
| Manufacturer | Cipla Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Antihistamine + Expectorant |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from direct sunlight and moisture. Keep the bottle tightly closed. Do not freeze. Keep out of reach of children. |
| Shelf Life | Typically 24 months from the date of manufacture, but refer to the expiry date printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Diphenhydramine is a first-generation antihistamine that competitively blocks histamine H1 receptors in the central nervous system and peripheral tissues. By blocking H1 receptors, it reduces allergic symptoms such as sneezing, runny nose, and itching, and it also crosses the blood-brain barrier to cause sedation, which helps suppress cough. Ammonium chloride is an expectorant that is thought to irritate the gastric mucosa, reflexively increasing respiratory tract fluid secretion, which lowers mucus viscosity and makes it easier to cough up. It also acts as a mild systemic acidifier. Together, these actions provide symptomatic relief of cough and associated allergy symptoms.
Mechanism Steps
💡 How to Take cofryl syrup
Strength: Each 5 mL of syrup contains Diphenhydramine 14.08 mg and Ammonium Chloride 138 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5 to 10 mL (one to two teaspoons) every 4 to 6 hours as needed for cough, not to exceed 4 doses in 24 hours. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and other medications being taken. Do not self-medicate beyond the recommended duration. If symptoms persist for more than 7 days, consult a doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine should not be given to children under the age recommended on the label or by a doctor, and it is contraindicated in newborns and premature infants. |
| Elderly Dosage | Elderly patients are more sensitive to the sedative and anticholinergic effects of diphenhydramine. Use with caution and consider a lower dose. Dose must be individualized by a qualified clinician based on renal and hepatic function and other medications. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary because diphenhydramine is excreted by the kidneys and ammonium chloride can worsen metabolic acidosis. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be necessary because diphenhydramine is metabolized in the liver. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose for adults is generally 40 mL (8 teaspoons) in 24 hours, but this must be confirmed by a qualified clinician. Do not exceed the recommended dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cofryl syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Alcohol | Major | |
| Tricyclic antidepressants | Major | |
| Fluoxetine | Moderate | |
| Opioids | Moderate | |
| Antihypertensives | Moderate | |
| Metoclopramide | Minor | |
| Antacids | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Alcohol and other central nervous system depressants
- Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
⚡ Moderate Interactions
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- Opioid analgesics
- Antihypertensive drugs
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine because it can significantly increase drowsiness, dizziness, and impairment of judgment and coordination. The combination can also increase the risk of respiratory depression. Do not drive or operate machinery if you have consumed alcohol.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to diphenhydramine, ammonium chloride, or any component of the formulation","Newborns and premature infants","Nursing mothers","Patients with narrow-angle glaucoma","Patients with stenosing peptic ulcer, pyloroduodenal obstruction, or bladder neck obstruction","Patients with severe liver or kidney disease","Patients taking monoamine oxidase inhibitors (MAOIs)"]
⚠️ Warnings & Precautions
["May cause marked drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other central nervous system depressants.","Use with caution in elderly patients due to increased risk of confusion, sedation, and falls.","Use with caution in patients with asthma, chronic bronchitis, or COPD.","Do not use for chronic cough or cough with excessive secretions unless directed by a doctor.","Consult a doctor if cough persists more than 7 days, recurs, or is accompanied by fever, rash, or persistent headache.","Keep out of reach of children; accidental overdose can be dangerous.","Do not exceed the recommended dose."]
🤱 Lactation Safety
Diphenhydramine is excreted in breast milk and may cause drowsiness or irritability in a nursing infant. Ammonium chloride may also pass into breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother. Consult a doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, confusion, hallucinations, seizures, respiratory depression, and cardiac arrhythmias. Ammonium chloride overdose can cause metabolic acidosis. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and symptomatic, including monitoring of vital signs, airway management, and correction of acid-base disturbances. There is no specific antidote for diphenhydramine; activated charcoal may be considered if ingestion is recent and the patient is alert. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Always follow the dose and duration recommended by your doctor or the product label. Do not exceed the stated dose because higher amounts can increase drowsiness and the risk of serious side effects. Avoid drinking alcohol while taking this medicine, as alcohol can intensify sedation and impair your ability to think and react. Do not drive, operate heavy machinery, or perform hazardous tasks until you know how this medicine affects you. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor before using this medicine. Do not give this medicine to children under the age recommended on the label or by your doctor, and never give it to a newborn or premature infant. If you have glaucoma, an enlarged prostate, difficulty urinating, asthma, chronic bronchitis, or kidney or liver disease, check with your doctor before use. Keep this medicine out of reach of children and store it in its original container at room temperature, away from direct sunlight and moisture. If your cough lasts more than seven days, comes back, or is accompanied by fever, rash, or persistent headache, stop using it and consult a doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more sensitive to the sedative and anticholinergic effects of diphenhydramine, which can increase the risk of confusion, falls, and urinary retention. Use with caution and consider a lower dose. Consult a doctor before use.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy or are pregnant, consult your doctor before using this medicine. Diphenhydramine may be used if clearly needed, but ammonium chloride is not recommended. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
After surgery, use this medicine only if prescribed by your surgeon or doctor. It can cause drowsiness and may interact with anesthetics and pain medications. Inform your healthcare provider that you are taking this medicine before any surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It can cause dry mouth and drowsiness, and may interact with sedatives or anesthetics used during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while taking this medicine because it can cause drowsiness and dizziness. Light activity is fine if you feel up to it, but do not push yourself. If you experience shortness of breath or chest discomfort, stop and seek medical advice.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause significant drowsiness and impair your ability to drive or operate machinery. It is best to avoid work that requires full attention until you know how it affects you. If your job involves operating heavy equipment or driving, discuss with your doctor about timing doses or alternative treatments.
🛑 When to Stop This Medicine
Stop taking this medicine and consult a doctor if your cough persists for more than 7 days, recurs, or is accompanied by fever, rash, or persistent headache. Also stop if you experience any serious side effects such as severe drowsiness, confusion, irregular heartbeat, or allergic reactions. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of diphenhydramine can lead to tolerance, dependence, and increased risk of cognitive impairment, especially in older adults. Ammonium chloride can cause metabolic acidosis if used excessively. If you need this medicine for more than 7 days, consult a doctor to determine the underlying cause of your cough.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps loosen mucus and soothe airways.
Evidence: Traditional, supportive careCan soothe cough and sore throat.
Evidence: Some clinical evidence for cough reliefHelps relieve nasal congestion.
Evidence: Well-established for congestion💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are unwell with a fever, it is generally advisable to postpone vaccination until you recover. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case customs or security asks for it. Store it in a cool, dry place away from direct sunlight; do not leave it in a hot car. If you are crossing time zones, continue your doses as prescribed, but do not exceed the maximum daily dose. If you are flying, keep the bottle in your carry-on bag if you need it during the flight. Check the laws of your destination country regarding cough syrups containing antihistamines, as some countries have restrictions.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 15 to 30 minutes after taking it.
A: It is intended for short-term use, generally not more than 7 days, unless directed by a doctor.
A: Consult your doctor or pharmacist before combining with other cold medicines, as they may contain overlapping ingredients.
A: Pediatric dosing is not established from available information. Consult a pediatrician.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for cofryl syrup
View AllAlternative brands with exact same active ingredient:
-
intadryl syrupIntas Pharmaceuticals Ltd ₹35.63 3.8% CHEAPER
-
odaril syrupMoraceae Pharmaceuticals Pvt Ltd ₹40.31 8.9% COSTLIER
-
tussberry-n syrupAcinta Pharmaceuticals Pvt Ltd ₹51.42 38.9% COSTLIER
-
new brethese syrupGalpha Laboratories Ltd ₹68.97 86.3% COSTLIER
-
suntuss cf syrupSuncare Formulations Pvt Ltd ₹70.00 89% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of cough.
Fact: It is intended for short-term relief of cough due to colds or allergies. It is not effective for all types of cough, such as those caused by asthma or pneumonia. - Myth: It is safe to take this medicine for a long time.
Fact: Prolonged use is not recommended without medical supervision due to the risk of side effects and masking of underlying conditions. - Myth: This medicine is safe for infants.
Fact: It is contraindicated in newborns and premature infants and should not be given to young children without a doctor's advice.
🔄 Alternative Options
Generic Alternatives
- Diphenhydramine + Ammonium Chloride oral syrup (generic)
Brand Alternatives
- Cofsils Cough Syrup