cofraj syrup - Uses, Price, Side Effects & Substitutes
What is cofraj syrup used for?
Ambitus Syrup (Ammonium Chloride + Bromhexine) is used to treat RESPIRATORY. It contains Ammonium Chloride (50mg) + Bromhexine (4mg), which Ammonium chloride increases bronchial secretions by osmotic action; Bromhexine r. Always consult your doctor before use. Take as prescribed.
- Generic Name: Ammonium Chloride + Bromhexine
- Manufacturer: Universal Micro Sciences
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cofraj syrup Uses & Benefits
Productive cough associated with respiratory tract infections, bronchitis, asthma, COPD
Off-label uses: None well-established
๐ Drug Information
| Generic Name(s) | Ammonium Chloride + Bromhexine |
| Brand Name | Ambitus Syrup |
| Manufacturer | Universal Micro Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Expectorant and Mucolytic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Ammonium chloride increases bronchial secretions by osmotic action; Bromhexine reduces mucus viscosity by depolymerizing mucopolysaccharides
Mechanism Steps
๐ก How to Take cofraj syrup
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cofraj syrup
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Dizziness
- Headache
๐จ Serious Side Effects
- Metabolic acidosis (with high doses of ammonium chloride)
- Bronchospasm (rare)
โ ๏ธ Rare Side Effects
- Allergic reactions
- Hypokalemia
- Hyperchloremia
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Codeine | Major | Reduced cough clearance due to suppressed cough reflex |
| Atropine | Major | Antagonism of bronchial secretion effects |
| Hydrochlorothiazide | Moderate | Increased risk of electrolyte imbalance |
| Prednisolone | Moderate | Possible increased potassium loss |
| Antacids | Minor | Reduced absorption of bromhexine |
๐จ Major Interactions
- Cough suppressants (e.g., codeine)
- Anticholinergics
โก Moderate Interactions
- Diuretics
- Corticosteroids
โน๏ธ Minor Interactions
- Antacids
- Food
๐ฝ๏ธ Food Interactions
No significant food interactions
๐ท Alcohol Interaction
May increase sedation risk; avoid concurrent use
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to any component, severe renal impairment, metabolic alkalosis
๐ Monitoring Parameters
Cough frequency and sputum characteristics, electrolyte levels, renal function
๐คฑ Lactation Safety
Excreted in breast milk; caution advised
๐ Overdose Management
Gastric lavage, supportive measures; monitor electrolytes and acid-base balance
โฐ Missed Dose
Take as soon as remembered; skip if almost time for next dose; do not double dose