cofaso tz 1000mg/125mg injection - Uses, Price, Side Effects & Substitutes
What is cofaso tz 1000mg/125mg injection used for?
Cegava TZ 1000 mg/125 mg Injection (Cefoperazone + Tazobactam) is used to treat ANTI INFECTIVES. It contains Cefoperazone (1000mg) + Tazobactum (125mg), which Cefoperazone inhibits bacterial cell wall synthesis by binding to penicillin-bin. Always consult your doctor before use. Take as prescribed.
- Generic Name: Cefoperazone + Tazobactam
- Manufacturer: Unifaith Biotech (P) Limited
- Form: Allopathy
- Pregnancy Category: B
- Prescription Required: Yes
๐ cofaso tz 1000mg/125mg injection Uses & Benefits
Treatment of infections caused by susceptible bacteria: intra-abdominal infections, urinary tract infections, respiratory tract infections, skin and soft tissue infections, septicemia
Off-label uses: Febrile neutropenia, Bone and joint infections, Meningitis
๐ Drug Information
| Generic Name(s) | Cefoperazone + Tazobactam |
| Brand Name | Cegava TZ 1000 mg/125 mg Injection |
| Manufacturer | Unifaith Biotech (P) Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) or intramuscular (IM) |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light; reconstituted solution stable for 24 hours at room temperature or 5 days under refrigeration |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cefoperazone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). Tazobactam irreversibly inhibits beta-lactamases, preventing degradation of cefoperazone.
Mechanism Steps
๐ก How to Take cofaso tz 1000mg/125mg injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cofaso tz 1000mg/125mg injection
โ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Injection site reactions
๐จ Serious Side Effects
- Clostridioides difficile-associated diarrhea
- Anaphylaxis
- Stevens-Johnson syndrome
- Hemolytic anemia
- Seizures
โ ๏ธ Rare Side Effects
- Pseudomembranous colitis
- Agranulocytosis
- Interstitial nephritis
- Hepatitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Alcohol | Major | Disulfiram-like reaction |
| Aminoglycosides | Major | Increased nephrotoxicity |
| Loop diuretics | Major | Increased nephrotoxicity |
| Probenecid | Moderate | Decreased renal excretion of tazobactam |
| Oral contraceptives | Moderate | Reduced contraceptive efficacy |
| Live vaccines | Moderate | Increased risk of infection |
| Antacids | Minor | No significant interaction |
| Iron supplements | Minor | No significant interaction |
๐จ Major Interactions
- Warfarin
- Alcohol
- Aminoglycosides
- Loop diuretics
โก Moderate Interactions
- Probenecid
- Oral contraceptives
- Live vaccines
โน๏ธ Minor Interactions
- Antacids
- Iron supplements
๐ฝ๏ธ Food Interactions
No significant food interactions
๐ท Alcohol Interaction
Disulfiram-like reaction (flushing, headache, nausea, vomiting) due to cefoperazone
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cephalosporins, penicillins, or beta-lactamase inhibitors; severe renal impairment (CrCl < 15 mL/min) without dose adjustment
๐ Monitoring Parameters
Renal function, hepatic function, complete blood count, signs of superinfection, prothrombin time (especially in patients at risk of bleeding)
๐คฑ Lactation Safety
Cefoperazone and tazobactam are excreted in breast milk in low concentrations; use with caution
๐ Overdose Management
Supportive care; hemodialysis may enhance elimination of tazobactam
โฐ Missed Dose
Administer as soon as remembered; if close to next dose, skip missed dose and resume regular schedule