cncalm plus 5mg/2mg tablet - Uses, Price, Side Effects & Substitutes
What is cncalm plus 5mg/2mg tablet used for?
Benzyzine (Trifluoperazine + Trihexyphenidyl) is used to treat NEURO CNS. It contains Trifluoperazine (5mg) + Trihexyphenidyl (2mg), which Trifluoperazine blocks dopamine D2 receptors; Trihexyphenidyl blocks muscarinic . Always consult your doctor before use. Take as prescribed.
- Generic Name: Trifluoperazine + Trihexyphenidyl
- Manufacturer: CNX Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ cncalm plus 5mg/2mg tablet Uses & Benefits
๐ Drug Information
| Generic Name(s) | Trifluoperazine + Trihexyphenidyl |
| Brand Name | Benzyzine |
| Manufacturer | CNX Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Antipsychotic + Anticholinergic |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF), protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Trifluoperazine blocks dopamine D2 receptors; Trihexyphenidyl blocks muscarinic acetylcholine receptors, reducing extrapyramidal side effects
Mechanism Steps
๐ก How to Take cncalm plus 5mg/2mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cncalm plus 5mg/2mg tablet
โ Common Side Effects
- Drowsiness
- dry mouth
- blurred vision
- constipation
- urinary retention
- dizziness
- weight gain
- extrapyramidal symptoms (dystonia, akathisia, parkinsonism)
๐จ Serious Side Effects
- Tardive dyskinesia
- neuroleptic malignant syndrome
- seizures
- QT prolongation
- arrhythmias
- agranulocytosis
- hepatotoxicity
- severe hypotension
โ ๏ธ Rare Side Effects
- Allergic reactions
- photosensitivity
- galactorrhea
- amenorrhea
- gynecomastia
- impotence
- cholestatic jaundice
- lupus-like syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Increased risk of hypertensive crisis and CNS toxicity |
| CNS depressants | Major | Additive sedation and respiratory depression |
| Anticholinergics | Major | Additive anticholinergic effects (dry mouth, constipation, urinary retention) |
| Levodopa | Major | Antagonism of levodopa effect |
| Quinidine | Major | Increased risk of cardiotoxicity (QT prolongation) |
| Antihypertensives | Moderate | Enhanced hypotensive effect |
| Lithium | Moderate | Increased risk of neurotoxicity |
| Antidiabetics | Moderate | Altered blood glucose levels |
| Antiepileptics | Moderate | Lowered seizure threshold |
| Antacids | Minor | Reduced absorption of trifluoperazine |
| Caffeine | Minor | Possible increased anxiety or restlessness |
| Smoking | Minor | Increased metabolism of trifluoperazine |
๐จ Major Interactions
- MAOIs
- CNS depressants
- Anticholinergics
- Levodopa
- Quinidine
โก Moderate Interactions
- Antihypertensives
- Lithium
- Antidiabetics
- Antiepileptics
โน๏ธ Minor Interactions
- Antacids
- Caffeine
- Smoking
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase trifluoperazine levels; high-fat meals may delay absorption
๐ท Alcohol Interaction
Enhanced CNS depression; avoid alcohol
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, CNS depression, coma, bone marrow suppression, narrow-angle glaucoma, myasthenia gravis, prostatic hypertrophy, urinary retention, severe liver disease
๐ Monitoring Parameters
Blood pressure, heart rate, ECG (QT interval), liver function, renal function, CBC, mental status, extrapyramidal symptoms, anticholinergic effects
๐คฑ Lactation Safety
Not recommended; excreted in breast milk
๐ Overdose Management
Supportive care; gastric lavage, activated charcoal; treat hypotension with IV fluids and pressors; avoid epinephrine; treat anticholinergic symptoms with physostigmine if severe
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip if close to next dose; do not double