clovolac t 400mg/4mg tablet - Uses, Price, Side Effects & Substitutes
What is clovolac t 400mg/4mg tablet used for?
Acropin-MR Tablet (Etodolac + Thiocolchicoside) is used to treat PAIN ANALGESICS. It contains Etodolac (400mg) + Thiocolchicoside (4mg), which Etodolac inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Thiocolchic. Always consult your doctor before use. Take as prescribed.
- Generic Name: Etodolac + Thiocolchicoside
- Manufacturer: Mediclove Biotech Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ clovolac t 400mg/4mg tablet Uses & Benefits
Management of acute musculoskeletal pain, inflammatory conditions, and muscle spasms.
Off-label uses: Chronic pain conditions, rheumatoid arthritis, osteoarthritis (etodolac alone); thiocolchicoside used for spasticity.
๐ Drug Information
| Generic Name(s) | Etodolac + Thiocolchicoside |
| Brand Name | Acropin-MR Tablet |
| Manufacturer | Mediclove Biotech Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID + Muscle Relaxant |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture and light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Etodolac inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Thiocolchicoside acts as a GABA-A receptor agonist and glycine receptor agonist, producing muscle relaxation.
Mechanism Steps
๐ก How to Take clovolac t 400mg/4mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of clovolac t 400mg/4mg tablet
โ Common Side Effects
- Nausea
- Dyspepsia
- Diarrhea
- Constipation
- Abdominal pain
- Headache
- Dizziness
- Somnolence
- Rash
๐จ Serious Side Effects
- GI bleeding
- Peptic ulcer
- Renal failure
- Hepatotoxicity
- Anaphylaxis
- Stevens-Johnson syndrome
- Cardiovascular thrombotic events
โ ๏ธ Rare Side Effects
- Aplastic anemia
- Agranulocytosis
- Pancreatitis
- Interstitial nephritis
- Toxic epidermal necrolysis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Aspirin | Major | Increased risk of GI ulceration and bleeding |
| Lithium | Major | Increased lithium levels and toxicity |
| Methotrexate | Major | Increased methotrexate toxicity |
| ACE inhibitors | Major | Reduced antihypertensive effect; increased renal impairment risk |
| Diuretics | Major | Reduced diuretic effect; increased nephrotoxicity risk |
| Corticosteroids | Major | Increased risk of GI ulceration |
| Other NSAIDs | Major | Additive GI and renal toxicity |
| Anticoagulants | Major | Increased bleeding risk |
| SSRIs | Major | Increased bleeding risk |
| Cyclosporine | Moderate | Increased nephrotoxicity |
| Tacrolimus | Moderate | Increased nephrotoxicity |
| Pemetrexed | Moderate | Increased pemetrexed toxicity |
| Digoxin | Moderate | Increased digoxin levels |
| Phenytoin | Moderate | Increased phenytoin levels |
| Antacids | Minor | Reduced absorption of etodolac |
| Cholestyramine | Minor | Reduced absorption of etodolac |
๐จ Major Interactions
- Warfarin
- Aspirin
- Lithium
- Methotrexate
- ACE inhibitors
- Diuretics
- Corticosteroids
- Other NSAIDs
- Anticoagulants
- SSRIs
โก Moderate Interactions
- Cyclosporine
- Tacrolimus
- Pemetrexed
- Digoxin
- Phenytoin
โน๏ธ Minor Interactions
- Antacids
- Cholestyramine
๐ฝ๏ธ Food Interactions
Food may delay absorption but not extent; avoid high-fat meals.
๐ท Alcohol Interaction
Increased risk of GI bleeding and hepatotoxicity; avoid alcohol.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to etodolac, thiocolchicoside, or other NSAIDs; active peptic ulcer; severe renal or hepatic impairment; third trimester pregnancy; history of asthma, urticaria, or allergic-type reactions after aspirin/NSAIDs; concomitant use with other NSAIDs; severe heart failure; bleeding disorders; children <12 years.
๐ Monitoring Parameters
Renal function, hepatic function, blood pressure, signs of GI bleeding, CBC, and serum electrolytes.
๐คฑ Lactation Safety
Not recommended; etodolac and thiocolchicoside are excreted in breast milk.
๐ Overdose Management
Symptomatic and supportive; gastric lavage, activated charcoal; monitor for GI bleeding, renal failure, and CNS depression.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose.