clorite-beta tablet - Uses, Price, Side Effects & Substitutes
What is clorite-beta tablet used for?
Avene (Abbott) 0.5mg/10mg Tablet (Clonazepam + Propranolol) is used to treat NEURO CNS. It contains Clonazepam (0.5mg) + Propranolol (20mg), which Clonazepam: Enhances GABA-A receptor activity; Propranolol: Non-selective beta-a. Always consult your doctor before use. Take as prescribed.
- Generic Name: Clonazepam + Propranolol
- Manufacturer: Medishri Healthcare
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ clorite-beta tablet Uses & Benefits
Anxiety disorders, panic disorder, essential tremor, migraine prophylaxis, performance anxiety
Off-label uses: Restless legs syndrome, bipolar disorder (adjunct), social anxiety disorder
๐ Drug Information
| Generic Name(s) | Clonazepam + Propranolol |
| Brand Name | Avene (Abbott) 0.5mg/10mg Tablet |
| Manufacturer | Medishri Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Benzodiazepine + Beta-blocker |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF), protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Clonazepam: Enhances GABA-A receptor activity; Propranolol: Non-selective beta-adrenergic receptor antagonist
Mechanism Steps
๐ก How to Take clorite-beta tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of clorite-beta tablet
โ Common Side Effects
- Drowsiness
- dizziness
- fatigue
- dry mouth
- bradycardia
- cold extremities
๐จ Serious Side Effects
- Respiratory depression
- severe bradycardia
- heart block
- bronchospasm
- suicidal thoughts
โ ๏ธ Rare Side Effects
- Blood dyscrasias
- hepatotoxicity
- Stevens-Johnson syndrome
- lupus-like syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | Increased CNS depression and hypotension |
| Opioids | Major | Additive CNS depression, respiratory depression risk |
| CYP3A4 inhibitors (e.g., ketoconazole) | Major | Increased clonazepam levels, toxicity risk |
| CYP2D6 inhibitors (e.g., fluoxetine) | Major | Increased propranolol levels, bradycardia risk |
| Verapamil | Major | Additive negative chronotropic effect |
| Antihypertensives | Moderate | Additive hypotensive effect |
| Antidiabetic agents | Moderate | May mask hypoglycemia symptoms |
| Digoxin | Moderate | Increased risk of bradycardia |
| Theophylline | Moderate | Antagonistic effect on bronchodilation |
| Caffeine | Minor | May reduce sedative effect of clonazepam |
๐จ Major Interactions
- CNS depressants (e.g., alcohol, opioids)
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP2D6 inhibitors (e.g., fluoxetine)
- Calcium channel blockers (e.g., verapamil)
โก Moderate Interactions
- Antihypertensives
- Antidiabetic agents
- Digoxin
- Theophylline
โน๏ธ Minor Interactions
- Caffeine
- Smoking (increases propranolol metabolism)
๐ฝ๏ธ Food Interactions
Avoid grapefruit juice (may increase clonazepam levels); Propranolol absorption may be increased with food
๐ท Alcohol Interaction
Avoid alcohol; increased CNS depression and hypotension risk
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, severe bradycardia, heart block, asthma, COPD, acute narrow-angle glaucoma, myasthenia gravis, severe hepatic impairment
๐ Monitoring Parameters
Heart rate, blood pressure, liver function, signs of CNS depression, withdrawal symptoms
๐คฑ Lactation Safety
Both drugs excreted in breast milk; avoid or monitor infant for sedation and bradycardia
๐ Overdose Management
Supportive care; flumazenil for clonazepam (caution in seizure patients); atropine and beta-agonists for propranolol overdose
โฐ Missed Dose
Take as soon as remembered unless close to next dose; do not double dose