clomivon 25mg tablet - Uses, Price, Side Effects & Substitutes
What is clomivon 25mg tablet used for?
Anafranil (Clomipramine) is used to treat NEURO CNS. It contains Clomipramine (25mg), which Inhibits the reuptake of serotonin and norepinephrine at the presynaptic neurona. Always consult your doctor before use. Take as prescribed.
- Generic Name: Clomipramine
- Manufacturer: Shine Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ clomivon 25mg tablet Uses & Benefits
Major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, chronic pain syndromes, cataplexy associated with narcolepsy.
Off-label uses: Premenstrual dysphoric disorder, body dysmorphic disorder, trichotillomania, pathological gambling, neuropathic pain.
๐ Drug Information
| Generic Name(s) | Clomipramine |
| Brand Name | Anafranil |
| Manufacturer | Shine Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressants |
| Route of Administration | Oral. |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits the reuptake of serotonin and norepinephrine at the presynaptic neuronal membrane, increasing their concentrations in the synaptic cleft.
Mechanism Steps
๐ก How to Take clomivon 25mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of clomivon 25mg tablet
โ Common Side Effects
- Dry mouth
- Constipation
- Blurred vision
- Drowsiness
- Dizziness
- Weight gain
- Sweating
- Tremor
- Sexual dysfunction
๐จ Serious Side Effects
- Serotonin syndrome
- Seizures
- QT prolongation
- Arrhythmias
- Orthostatic hypotension
- Agranulocytosis
- Hepatitis
- Suicidal thoughts/behavior
โ ๏ธ Rare Side Effects
- Pancreatitis
- Pulmonary fibrosis
- Lupus-like syndrome
- Photosensitivity
- Galactorrhea
- SIADH
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Risk of serotonin syndrome; contraindicated within 14 days of MAOI use. |
| CYP1A2 inhibitors | Major | Increased clomipramine levels; monitor for toxicity. |
| CYP2D6 inhibitors | Major | Increased clomipramine levels; dose adjustment may be needed. |
| Serotonergic drugs | Major | Risk of serotonin syndrome; avoid combination. |
| CNS depressants | Major | Additive sedation; use caution. |
| Anticholinergic drugs | Moderate | Additive anticholinergic effects. |
| Antihypertensives | Moderate | May enhance hypotensive effects. |
| Sympathomimetics | Moderate | Risk of hypertension and arrhythmias. |
| Oral anticoagulants | Moderate | Increased anticoagulant effect; monitor INR. |
| Cimetidine | Minor | May increase clomipramine levels. |
| Methylphenidate | Minor | May increase clomipramine levels. |
| Smoking | Minor | May decrease clomipramine levels via CYP1A2 induction. |
๐จ Major Interactions
- MAOIs
- CYP1A2 inhibitors
- CYP2D6 inhibitors
- Serotonergic drugs
- CNS depressants
โก Moderate Interactions
- Anticholinergic drugs
- Antihypertensives
- Sympathomimetics
- Oral anticoagulants
โน๏ธ Minor Interactions
- Cimetidine
- Methylphenidate
- Smoking
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase clomipramine levels via CYP3A4 inhibition.
๐ท Alcohol Interaction
Alcohol may potentiate CNS depressant effects; avoid concurrent use.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to clomipramine or any component; recent myocardial infarction; concurrent use with MAOIs; narrow-angle glaucoma; urinary retention; severe hepatic impairment.
๐ Monitoring Parameters
Mental status, blood pressure, heart rate, ECG (QT interval), liver function tests, serum drug levels (if toxicity suspected), suicidal ideation.
๐คฑ Lactation Safety
Clomipramine is excreted in breast milk; caution advised; monitor infant for drowsiness and feeding
๐ Overdose Management
Activated charcoal, gastric lavage, supportive care; monitor ECG, vital signs; treat arrhythmias with sodium bicarbonate; avoid physostigmine due to risk of seizures.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for clomivon 25mg tablet
View AllAlternative brands with exact same active ingredient (Clomipramine (25mg)):
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clomine 25mg tabletPsychotropics India Ltd โน18.77 40.5% CHEAPER
-
clomizil 25mg capsuleGufic Bioscience Ltd โน22.03 30.1% CHEAPER
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clopic 25mg tabletAlpic Remedies Ltd โน27.19 13.7% CHEAPER
-
clomifril 25mg tabletTorrent Pharmaceuticals Ltd โน29.05 7.8% CHEAPER
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clomijet 25mg tabletDagon Pharmaceuticals Pvt Ltd โน29.06 7.8% CHEAPER
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ocnil 25mg tabletRaikar Pharmaceuticals Pvt Ltd โน32.00 1.5% COSTLIER
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syconil 25mg tabletPsycormedies โน32.48 3% COSTLIER
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imi-ci 25mg tabletSunrise Remedies Pvt Ltd โน32.50 3.1% COSTLIER
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ecmin 25mg tabletElite Pharma Pvt Ltd โน34.00 7.9% COSTLIER
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klomin 25mg tabletRKG Pharma โน35.20 11.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.