Clobiotic Eye Drop: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Sudden severe eye pain or loss of vision
- Swelling of the face, lips, tongue, or throat
- Rash or hives with difficulty breathing
- Unusual tiredness, pale skin, or easy bruising
- Fever, sore throat, or frequent infections
- Severe eye redness or swelling that gets worse
- New blurred vision or seeing halos around lights
- Eye discharge that becomes thick, yellow, or green
- No improvement after 3 to 5 days of treatment
- Any sign of an allergic reaction, such as itching or swelling of the eyelids
If experiencing severe symptoms, call emergency services immediately.
What is clodide ear drop used for?
This medicine is a combination eye drop containing chloramphenicol, an antibiotic, and clotrimazole, an antifungal. It is used to treat eye infections that may be caused by both bacteria and fungi. It works by stopping bacterial protein production and damaging fungal cell membranes. It is for ophthalmic use only and should be used exactly as prescribed by an eye doctor.
- Generic Name: Chloramphenicol + Clotrimazole
- Manufacturer: Torrent Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 clodide ear drop के बारे में (Hindi Summary)
उपयोग: यह दवा एक संयुक्त आई ड्रॉप है जिसमें क्लोरैम्फेनिकॉल (एक एंटीबायोटिक) और क्लोट्रिमाज़ोल (एक एंटीफंगल) शामिल हैं। इसका उपयोग आंखों के उन संक्रमणों के इलाज के लिए किया जाता है जो बैक्टीरिया और फंगस दोनों के कारण हो सकते हैं। यह आंखों में लगाने वाली दवा है और इसे डॉक्टर के निर्देशानुसार ही इस्तेमाल करना चाहिए। यह दवा बैक्टीरिया के प्रोटीन बनाने की प्रक्रिया को रोकती है और फंगस की कोशिका झिल्ली को नष्ट करती है। इसे आंखों के डॉक्टर की सलाह के बिना नहीं खरीदना चाहिए और न ही किसी और के साथ साझा करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में आंख में हल्की जलन, चुभन, धुंधली दृष्टि, लालिमा या पानी आना शामिल है। ये आमतौर पर हल्के होते हैं और कुछ मिनटों में ठीक हो जाते हैं। कभी-कभी गंभीर एलर्जी, आंख में तेज दर्द, सूजन या दृष्टि में कमी हो सकती है। बहुत दुर्लभ मामलों में क्लोरैम्फेनिकॉल के कारण रक्त विकार हो सकता है। अगर आपको असामान्य थकान, पीली त्वचा, आसानी से चोट लगना या बार-बार संक्रमण हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को केवल आंखों में ही लगाएं और डॉक्टर के बताए अनुसार ही उपयोग करें। उपयोग से पहले और बाद में हाथ धोएं। ड्रॉपर की नोक को आंख, पलक या किसी सतह से न छुएं। अगर आप कॉन्टैक्ट लेंस पहनते हैं, तो दवा लगाने से पहले उन्हें निकाल दें और डॉक्टर की सलाह के बिना दोबारा न पहनें। दवा की बोतल को ठंडी और सूखी जगह पर रखें। बच्चों की पहुंच से दूर रखें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। धुंधली दृष्टि होने पर वाहन न चलाएं।
💊 clodide ear drop Uses & Benefits
[{"condition":"Bacterial conjunctivitis with suspected fungal co-infection","description":"This medicine is used when the eye doctor suspects that both bacteria and fungi are contributing to the eye infection, which can happen after injury or in people with weakened eye defenses.","evidence":"Limited"},{"condition":"Fungal keratitis with bacterial superinfection","description":"In some cases of fungal infection of the cornea, bacteria may also be present, and this combination drop may be chosen to cover both types of organisms.","evidence":"Limited"},{"condition":"Post-traumatic ocular infection prophylaxis","description":"After a penetrating eye injury or foreign body removal, doctors may use this medicine to reduce the risk of mixed bacterial and fungal infection.","evidence":"Limited"},{"condition":"Blepharoconjunctivitis with mixed organisms","description":"When the eyelid margins and conjunctiva are inflamed and both bacterial and fungal elements are suspected, this medicine may be prescribed.","evidence":"Limited"}]
Off-label uses: [{"condition":"Chronic blepharitis not responding to standard treatment","description":"Occasionally, eye doctors may try this combination when standard antibacterial or antifungal drops alone have not worked, but this is not a standard approved use.","evidence":"Limited"}]
Primary treatment for: Mixed bacterial and fungal eye infections
Also treats: Bacterial conjunctivitis with suspected fungal involvement, Fungal keratitis with bacterial superinfection, Post-traumatic ocular infection, Blepharoconjunctivitis with mixed organisms
📋 Drug Information
| Generic Name(s) | Chloramphenicol + Clotrimazole |
| Brand Name | Clocibiotic Ear Drop |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OTOLOGICALS |
| Action Class | Antibiotic + Antifungal |
| Route of Administration | Ophthalmic (topical eye drop) |
| Storage | Store at room temperature between 15°C and 30°C. Protect from light and moisture. Keep the bottle tightly closed when not in use. Do not freeze. |
| Shelf Life | The shelf life is usually 24 months from the date of manufacture, but check the expiry date on the bottle. Once opened, use within the period recommended by the manufacturer or your pharmacist, usually 4 weeks for eye drops. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients that attack different types of organisms. Chloramphenicol is a broad-spectrum antibiotic that binds to the bacterial ribosome and blocks the formation of peptide bonds, which stops bacteria from making proteins they need to survive and multiply. Clotrimazole is an azole antifungal that inhibits the enzyme lanosterol 14-alpha-demethylase, which is needed to make ergosterol, a key component of the fungal cell membrane. Without enough ergosterol, the fungal membrane becomes leaky and the fungus dies. Because the two ingredients work on different targets, the combination can address mixed bacterial and fungal eye infections.
Mechanism Steps
💡 How to Take clodide ear drop
Strength: This medicine is supplied as an eye drop. The exact strength and concentration are not established from the available information. Check the label on your bottle for the specific strength.
Dosage Information
| Adult Dosage | The usual adult dose is one drop in the affected eye or eyes, as often as prescribed by your eye doctor. The frequency may range from every 1 to 2 hours for severe infections to 3 to 4 times a day for milder ones. The exact dose and duration depend on the type and severity of the infection. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not change the dose or stop the medicine without talking to your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician or pediatric eye specialist. |
| Elderly Dosage | Older adults can usually use this medicine at the same dose as younger adults. However, because older adults may have more health conditions and take more medicines, the doctor will check for interactions and monitor for side effects more closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is established for people with kidney disease when using this eye drop. However, if you have severe kidney disease, tell your doctor before using this medicine. |
| Hepatic Impairment | No specific dose adjustment is established for people with liver disease when using this eye drop. Because chloramphenicol is processed by the liver, people with severe liver disease should use this medicine only under close medical supervision. |
| Maximum Daily Dose | The maximum daily dose depends on the prescribed frequency and the severity of the infection. Do not exceed the frequency recommended by your eye doctor. For educational reference only, individual dosing must be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of clodide ear drop
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Phenytoin | Moderate | |
| Oral hypoglycemic agents | Moderate | |
| Chemotherapy agents | Major | |
| Other chloramphenicol products | Major | |
| Other eye drops | Minor | |
| Contact lenses | Moderate | |
| Live vaccines | Minor | |
| Cyclosporine eye drops | Moderate | |
| Timolol eye drops | Minor |
🚨 Major Interactions
- Other chloramphenicol-containing products
- Bone marrow suppressant drugs (for example, chemotherapy agents)
⚡ Moderate Interactions
- Warfarin and other oral anticoagulants
- Phenytoin and other drugs metabolized by liver enzymes
- Oral hypoglycemic agents
🍷 Alcohol Interaction
There is no known direct interaction between this eye drop and alcohol. However, alcohol can affect your immune system and liver, and it may worsen some eye conditions. It is best to avoid heavy alcohol use while you are recovering from an eye infection.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to chloramphenicol, clotrimazole, or any ingredient in this medicine","Viral eye infections such as herpes simplex keratitis","Fungal eye infections that are being treated with a different specific antifungal, unless directed by a doctor","Use in children under 2 years of age unless specifically prescribed by a pediatric eye doctor","Use in people with a history of bone marrow suppression or blood disorders, unless approved by a doctor","Use in people with severe liver disease, unless approved by a doctor"]
⚠️ Warnings & Precautions
["Do not use this medicine for more than the recommended duration without a fresh eye examination.","Prolonged use can lead to antibiotic resistance or fungal overgrowth.","Stop the medicine and seek medical help if you notice signs of a serious allergic reaction.","Do not touch the dropper tip to any surface, including your eye, to avoid contamination.","Remove contact lenses before use and do not reinsert them until your doctor says it is safe.","Tell your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Tell your doctor about all other medicines you use, especially warfarin, phenytoin, and diabetes medicines.","Do not drive or operate machinery if your vision is blurred after using the drop.","Keep this medicine out of the reach of children.","Do not use the medicine after the expiry date or if the solution looks cloudy or has particles."]
🤱 Lactation Safety
It is not known whether chloramphenicol or clotrimazole pass into breast milk in significant amounts after eye drop use. Because small amounts may be absorbed, caution is advised. Talk to your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose from an eye drop is unlikely because the amount used is very small. If someone accidentally swallows this medicine, seek medical help immediately. Signs of chloramphenicol overdose may include nausea, vomiting, and blood problems. Treatment is supportive and based on symptoms. Contact a poison control center or go to the nearest emergency room if ingestion occurs.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not use a double dose to make up for a missed one. If you are unsure, call your doctor or pharmacist.
Additional Safety Advice
Use this medicine only in the eye, exactly as your doctor prescribed. Wash your hands thoroughly before and after each dose. Do not touch the dropper tip to your eye, eyelid, fingers, or any surface, because that can contaminate the bottle. If you wear contact lenses, remove them before using this medicine and do not put them back in until your doctor says it is safe. Do not use this medicine for more than the recommended number of days without a fresh eye examination. Do not use it to treat a red eye that has not been evaluated by a doctor, because many red eyes are due to viruses or allergies and will not respond to this medicine. Keep the bottle closed tightly when not in use and store it out of reach of children. Do not use the drop if the liquid looks cloudy, has particles, or if the expiry date has passed. If you are pregnant, planning pregnancy, or breastfeeding, tell your doctor before using this medicine. Do not drive or operate heavy machinery if your vision is blurred after putting in the drop. If you miss a dose, follow your doctor's or pharmacist's advice and do not double the next dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults can use this medicine, but they may be more likely to have other health conditions and take multiple medicines. The doctor will check for interactions, especially with blood thinners, diabetes medicines, and drugs that affect the liver. Older adults should also be monitored for signs of allergic reactions and blood disorders, although these are rare. If you have trouble putting in eye drops, ask a family member or caregiver for help.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, talk to your doctor before using this medicine. Chloramphenicol and clotrimazole have not been well studied in pregnancy when used as eye drops. Your doctor will weigh the benefits and risks. If you become pregnant while using this medicine, contact your doctor right away.
🏥 Post-Surgery Considerations
If you have had eye surgery, do not use this medicine unless your eye surgeon specifically prescribes it. After surgery, the eye is more vulnerable to infection, and your surgeon will choose the safest and most effective medicine for your situation. Always follow your surgeon's instructions about eye drops and follow-up visits.
🦷 Dental Procedures
There is no direct interaction between this eye drop and dental procedures. However, tell your dentist about all medicines you are using, including eye drops, before any dental work. If you are having dental surgery and take blood thinners, your dentist and doctor will coordinate your care.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You can usually continue light exercise while using this medicine, but avoid swimming or any water sports until the infection has cleared, because water can introduce new germs and worsen the infection. If your vision is blurred after using the drop, avoid activities that require clear vision, such as cycling or lifting heavy weights. Always follow your eye doctor's advice about physical activity during recovery.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause temporary blurred vision right after you put in the drop. Wait until your vision clears before driving, operating machinery, or doing tasks that require clear vision. If you work in a dusty or dirty environment, wear protective eyewear to prevent further irritation. You can usually continue your normal daily activities, but avoid swimming and contact sports until the infection has cleared. If your job involves close work or computer use, take frequent breaks to rest your eyes.
🛑 When to Stop This Medicine
Stop using this medicine and contact your eye doctor if you develop a severe allergic reaction, severe eye pain, sudden vision loss, or signs of a blood disorder such as unusual tiredness, pale skin, or easy bruising. Also stop if your symptoms get worse or do not improve after 3 to 5 days. Do not stop the medicine early just because you feel better, because the infection may return. Always complete the full course unless your doctor tells you otherwise.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of antibiotic resistance, fungal overgrowth, and rare blood disorders. It should only be used for the duration recommended by your eye doctor. If you need to use it for more than a few weeks, your doctor may monitor your blood counts and eye health closely. Do not use this medicine continuously without regular eye examinations.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Applying a clean, warm compress to the closed eye can help relieve discomfort and loosen crusts in some eye infections.
Evidence: LimitedGently cleaning the eyelid margins with a mild cleanser or diluted baby shampoo can help control blepharitis and prevent recurrence.
Evidence: Well-establishedIf the exact organism is identified, your doctor may switch to a single-agent eye drop that targets only the bacteria or only the fungus.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There is no known interaction between this eye drop and vaccines. However, if you are scheduled to receive a live vaccine, tell your doctor that you are using this medicine. In general, minor eye infections do not require delaying vaccination, but your doctor will decide based on your overall health.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not freeze the bottle.
✅ DO
Keep the bottle tightly closed when not in use.
❌ DON'T
Do not leave the cap off for long periods.
✅ DO
Protect the bottle from direct sunlight and heat.
❌ DON'T
Do not store it in a hot car or near a stove.
✅ DO
Keep the medicine out of the reach of children.
❌ DON'T
Do not transfer the medicine to another container.
✅ DO
Check the expiry date before use.
❌ DON'T
Do not use the medicine if it looks cloudy or has particles.
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription in case you need to show it at customs or security. Keep the bottle in your hand luggage so it does not get lost or exposed to extreme temperatures in checked baggage. Store it at room temperature and protect it from direct sunlight. If you are crossing time zones, continue using the medicine at the same intervals as prescribed, but you can adjust the timing gradually to fit your new schedule. Do not leave the bottle in a hot car or in direct sunlight. If you run out while traveling, visit a local pharmacy or doctor with your prescription to get a replacement.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Some improvement in redness and discomfort may be noticed within 1 to 2 days. However, the full effect may take several days to weeks, depending on the type and severity of the infection. If there is no improvement after 3 to 5 days, contact your eye doctor.
A: No. This medicine is specifically for eye infections that may be caused by both bacteria and fungi. It is not effective for viral eye infections, allergic eye conditions, or dry eye. Using it for the wrong condition can be harmful.
A: If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. If it is almost time, skip the missed dose and continue with your regular schedule. Do not use a double dose.
A: No. You should remove your contact lenses before using this medicine and should not wear them again until your eye doctor says it is safe. Wearing lenses during an eye infection can worsen the infection and delay healing.
A: Pediatric dosing is not established from available information. This medicine should be used in children only if prescribed by a pediatric eye specialist.
A: Serious side effects are rare but include severe allergic reactions, severe eye pain, sudden vision loss, and blood disorders. If you notice swelling of the face or throat, difficulty breathing, unusual tiredness, pale skin, or easy bruising, stop the medicine and seek immediate medical help.
🤔 Common Patient Concerns
🔄 Substitutes for clodide ear drop
View AllAlternative brands with exact same active ingredient:
-
otigard ear dropJawa Pharmaceuticals Pvt Ltd ₹18.21 8.8% CHEAPER
-
oticlor eye dropJawa Pharmaceuticals Pvt Ltd ₹19.69 1.4% CHEAPER
-
clobiotic eye dropIndoco Remedies Ltd ₹25.78 29.2% COSTLIER
-
otisafe eye dropDWD Pharmaceuticals Ltd ₹27.19 36.2% COSTLIER
-
lbc ear dropGreenco Biologicals Pvt Ltd ₹29.00 45.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This eye drop can be used for any red eye.
Fact: This medicine is only for specific bacterial and fungal eye infections. Using it for viral or allergic red eye can be harmful and may delay the correct treatment. - Myth: You can stop using this medicine as soon as your eye looks better.
Fact: You should complete the full course prescribed by your doctor. Stopping early can allow the infection to come back and may lead to resistance. - Myth: This medicine is completely safe for long-term use.
Fact: Prolonged use can cause side effects, including rare blood disorders and fungal overgrowth. It should only be used for the duration recommended by your eye doctor. - Myth: Sharing eye drops with family members is fine.
Fact: Never share eye drops. This can spread infection and cause contamination of the bottle.
🔄 Alternative Options
Generic Alternatives
- Chloramphenicol and clotrimazole eye drops
Brand Alternatives
- Clobiotic eye drop