Aplaz 1mg Tablet (Clonazepam 1mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Slow, shallow breathing or difficulty breathing
- Extreme sleepiness or difficulty staying awake
- Confusion, hallucinations, or unusual behavior changes
- Seizures that are new or worsening
- Severe allergic reaction with rash, swelling of face or throat, or difficulty breathing
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
- Unusual bruising or bleeding
- Inability to pass urine
If experiencing severe symptoms, call emergency services immediately.
What is clodep 1mg tablet md used for?
This medicine is an oral tablet containing clonazepam 1 mg, a benzodiazepine used to treat seizure disorders, panic disorder, and severe anxiety. It works by enhancing the calming effect of GABA in the brain. It can cause drowsiness and dependence, so it must be taken exactly as prescribed and never stopped suddenly.
- Generic Name: Clonazepam
- Manufacturer: Mission Research Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 clodep 1mg tablet md के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोनाजेपम 1 मिलीग्राम की गोली है, जो बेंजोडायजेपीन वर्ग की दवा है। इसका उपयोग मुख्य रूप से मिर्गी और दौरे (सीज़र) के इलाज में किया जाता है। यह पैनिक डिसऑर्डर और गंभीर चिंता (एंग्जायटी) के इलाज में भी प्रभावी है। यह दिमाग में GABA नामक रसायन की शांत प्रभाव को बढ़ाकर काम करती है, जिससे दौरे और घबराहट कम होती है। यह दवा केवल डॉक्टर की सलाह पर ही लेनी चाहिए और इसे अचानक बंद नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, अस्थिरता, थकान, मांसपेशियों में कमजोरी और ध्यान केंद्रित करने में कठिनाई शामिल हैं। कुछ लोगों को याददाश्त की समस्या, भ्रम, धुंधली दृष्टि या मूड में बदलाव भी हो सकता है। गंभीर दुष्प्रभावों में सांस लेने में कठिनाई, अत्यधिक नींद आना, और व्यवहार में अचानक बदलाव शामिल हैं। लंबे समय तक उपयोग से इसकी लत लग सकती है और अचानक बंद करने पर withdrawal के लक्षण हो सकते हैं।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें और कभी भी अपने आप डोज न बदलें या दवा बंद न करें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक गाड़ी चलाने या मशीन चलाने से बचें। इस दवा के साथ शराब या अन्य नींद लाने वाली दवाएं न लें, क्योंकि इससे गंभीर नींद और सांस की समस्या हो सकती है। दवा को कमरे के तापमान पर, मूल डिब्बे में, नमी और धूप से दूर रखें। बच्चों की पहुंच से दूर रखें।
💊 clodep 1mg tablet md Uses & Benefits
[{"condition":"Epilepsy and seizure disorders","description":"This medicine is used as an add-on treatment for absence seizures, myoclonic seizures, and other generalized seizure types when other medicines are not fully effective.","evidence":"Well-established"},{"condition":"Panic disorder","description":"This medicine helps reduce the frequency and intensity of panic attacks and is sometimes used as short-term therapy while other treatments take effect.","evidence":"Well-established"},{"condition":"Severe anxiety","description":"This medicine may be prescribed for short-term relief of severe anxiety that significantly affects daily functioning.","evidence":"Established"},{"condition":"REM sleep behavior disorder","description":"This medicine is sometimes used to reduce dream-enactment behaviors and improve sleep safety in this condition.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Restless legs syndrome","description":"This medicine has been used off-label in some patients to reduce nighttime leg discomfort, but it is not a first-line treatment.","evidence":"Limited"},{"condition":"Bipolar disorder adjunct","description":"This medicine may be added short-term to stabilize mood in some patients, but evidence is limited and it is not a standard primary treatment.","evidence":"Limited"},{"condition":"Tardive dyskinesia","description":"This medicine has been tried off-label for involuntary movements, but results are inconsistent and it is not routinely recommended.","evidence":"Limited"}]
Primary treatment for: Epilepsy and seizure disorders
Also treats: Panic disorder, Severe anxiety, REM sleep behavior disorder
📋 Drug Information
| Generic Name(s) | Clonazepam |
| Brand Name | Anxipam |
| Manufacturer | Mission Research Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Benzodiazepines |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C (59°F to 86°F). Keep it in its original container, tightly closed, away from moisture, heat, and direct light. Do not store it in the bathroom. Keep out of reach of children and pets. |
| Shelf Life | The shelf life of this medicine is typically 24 to 36 months from the date of manufacture, depending on the manufacturer. Always check the expiry date on the packaging before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to benzodiazepine sites on the GABA-A receptor complex in the brain. This binding increases the frequency of chloride channel opening when GABA, the brain's main inhibitory chemical, attaches to the receptor. The result is increased chloride flow into nerve cells, which makes these cells less excitable. This enhanced inhibitory effect helps control abnormal electrical activity that causes seizures and reduces the excessive nerve firing associated with panic and anxiety.
Mechanism Steps
💡 How to Take clodep 1mg tablet md
Strength: This medicine is available as an immediate-release oral tablet containing 1 mg of clonazepam.
Dosage Information
| Adult Dosage | The usual starting dose of this medicine for adults is 0.5 mg to 1 mg taken orally once or twice daily, depending on the condition being treated. For seizure disorders, the dose may be gradually increased to a maximum of 20 mg per day in divided doses. For panic disorder, the usual dose is 0.25 mg to 1 mg twice daily, with a maximum of 4 mg per day. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. |
| Pediatric Dosage | Pediatric dosing of this medicine is not established from available information for all age groups. For seizures in children, the dose is typically calculated based on body weight and must be determined by a pediatrician. Consult a pediatrician for appropriate dosing. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of this medicine and are at higher risk of sedation, confusion, falls, and fractures. The starting dose should be low, typically 0.25 mg once or twice daily, and increased slowly only if needed. Regular monitoring for side effects is essential. |
| Renal Impairment | This medicine is primarily metabolized in the liver, so renal impairment usually does not require major dose adjustment. However, in severe renal impairment, metabolites may accumulate, and caution is advised. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | This medicine is extensively metabolized in the liver, and its clearance may be reduced in patients with hepatic impairment. Dose reduction and careful monitoring are recommended in patients with mild to moderate liver disease. This medicine is contraindicated in severe liver disease. |
| Maximum Daily Dose | The maximum daily dose of this medicine for adults is generally 20 mg per day for seizure disorders and 4 mg per day for panic disorder. However, the exact maximum dose must be determined by a qualified clinician based on the individual patient's condition and response. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of clodep 1mg tablet md
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Opioid pain medicines | Major | |
| Alcohol | Major | |
| CNS depressants | Major | |
| Strong CYP3A4 inhibitors | Major | |
| Oral contraceptives | Moderate | |
| Valproic acid | Moderate | |
| Cimetidine | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Opioid pain medicines
- Alcohol
- CNS depressants such as barbiturates, antipsychotics, and hypnotics
- Strong CYP3A4 inhibitors such as ketoconazole, itraconazole, and ritonavir
⚡ Moderate Interactions
- Oral contraceptives
- Valproic acid
- Cimetidine
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol enhances the sedative and respiratory depressant effects of clonazepam, which can lead to dangerous levels of sedation, slowed breathing, and even death. It also increases the risk of falls, accidents, and impaired judgment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to clonazepam or other benzodiazepines","Severe liver disease","Narrow-angle glaucoma","Severe respiratory insufficiency or sleep apnea","Myasthenia gravis","Acute alcohol or drug intoxication","Pregnancy, especially in the first trimester, unless clearly necessary"]
⚠️ Warnings & Precautions
["This medicine can cause significant drowsiness and impair your ability to drive or operate machinery. Avoid these activities until you know how it affects you.","Do not stop this medicine suddenly, as it can cause withdrawal symptoms such as seizures, anxiety, insomnia, and tremors. Taper gradually under medical supervision.","Long-term use can lead to tolerance, dependence, and addiction. Use the lowest effective dose for the shortest possible time.","This medicine can cause respiratory depression, especially when combined with opioids, alcohol, or other sedatives. Seek emergency help if breathing becomes slow or shallow.","Elderly patients are more sensitive to the sedative and cognitive effects of this medicine and are at higher risk of falls and fractures.","This medicine may cause paradoxical reactions such as agitation, aggression, or hallucinations, particularly in children and elderly patients.","Use with caution in patients with kidney or liver disease, as dose adjustment may be needed."]
🤱 Lactation Safety
This medicine passes into breast milk and may cause sedation, poor feeding, and weight loss in a breastfed infant. Breastfeeding is not recommended while taking this medicine unless the benefits clearly outweigh the risks. If breastfeeding is continued, the infant should be monitored for drowsiness and poor feeding.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, confusion, coma, respiratory depression, and death, especially when combined with alcohol or other central nervous system depressants. If overdose is suspected, seek emergency medical help immediately. The specific antidote for benzodiazepine overdose is flumazenil, which should only be administered by a qualified healthcare professional in a hospital setting. Supportive care, including airway management and monitoring of vital signs, is essential.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if it is less than half the dosing interval away. If more than half the interval has passed, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, and never change the dose or stop it suddenly on your own. Avoid driving, operating heavy machinery, or performing activities that require full alertness until you know how this medicine affects you. Do not drink alcohol or use other sedative medicines while taking this product, as this can cause dangerous sedation and breathing problems. Keep all follow-up appointments so your doctor can monitor your response and adjust the dose if needed. Store this medicine in its original container at room temperature, away from moisture, heat, and direct light, and keep it out of reach of children. If you are pregnant, planning pregnancy, or breastfeeding, inform your doctor before taking this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative and cognitive effects of this medicine. They are at higher risk of falls, fractures, confusion, and respiratory depression. The starting dose should be low, and increases should be gradual. Regular monitoring for side effects and dose adjustment is essential. Avoid combining with other sedatives or alcohol.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. This medicine may increase the risk of congenital malformations, especially when used in the first trimester. Your doctor may recommend alternative treatments or a gradual taper before conception. Do not stop the medicine suddenly on your own.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It can interact with anesthetic agents and other medicines used during surgery, increasing the risk of excessive sedation and respiratory depression. Your doctor may adjust the dose or temporarily stop the medicine before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It can interact with sedatives or anesthetics used during dental work, increasing the risk of excessive sedation. Your dentist may need to adjust the medications used or take extra precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness, dizziness, and unsteadiness, which may increase the risk of falls or injuries during exercise. Avoid high-impact or balance-demanding activities until you know how the medicine affects you. Always warm up properly and stay hydrated. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause significant drowsiness and impair your ability to concentrate, which may affect your work performance and daily activities. Avoid driving, operating heavy machinery, or performing tasks that require full alertness until you know how the medicine affects you. Inform your employer if your job involves such activities. You may need to adjust your work schedule or duties temporarily.
🛑 When to Stop This Medicine
You should not stop taking this medicine on your own. Your doctor will decide when and how to stop it based on your condition and response to treatment. If you experience severe side effects or wish to stop, consult your doctor, who will gradually taper the dose to prevent withdrawal symptoms. Stopping suddenly can cause seizures, anxiety, insomnia, and other serious withdrawal effects.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, meaning you may need higher doses to achieve the same effect. It can also cause dependence and withdrawal symptoms when stopped. Cognitive effects such as memory problems and difficulty concentrating may occur. Regular monitoring by a doctor is essential, and the need for continued therapy should be reviewed periodically. In some cases, long-term use may affect sleep quality and mood.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
CBT is an effective non-medicine treatment for panic disorder and anxiety, and it can complement or reduce the need for this medicine.
Evidence: Well-establishedTechniques such as deep breathing, progressive muscle relaxation, and mindfulness can help manage anxiety and reduce panic symptoms.
Evidence: EstablishedOther anti-seizure medicines may be used alone or in combination for epilepsy, depending on the seizure type.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking. There is no need to stop this medicine before vaccination unless your doctor advises otherwise.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate unless specified.
✅ DO
Keep in the original container, tightly closed.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of reach of children and pets.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging along with a copy of your prescription. Keep it in your hand luggage to avoid loss or exposure to extreme temperatures. If crossing time zones, consult your doctor about how to adjust your dosing schedule. Store it at room temperature and avoid leaving it in a hot car or checked luggage. Check the customs regulations of your destination country regarding controlled medicines, as some countries have strict rules.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 20 to 60 minutes after taking a dose. However, the full benefits for conditions like panic disorder or epilepsy may take several weeks of regular use.
A: No, you should never stop this medicine suddenly. Abrupt discontinuation can cause withdrawal symptoms such as seizures, anxiety, insomnia, and tremors. Your doctor will gradually reduce the dose under supervision.
A: This medicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It may increase the risk of congenital malformations and cause withdrawal symptoms in the newborn. Consult your doctor if you are pregnant or planning pregnancy.
A: No, alcohol should be completely avoided while taking this medicine. It can cause severe sedation, respiratory depression, and dangerous falls.
A: Yes, this medicine can cause dependence and addiction, especially with long-term use or misuse. It should be used only under medical supervision and for the shortest duration necessary.
🤔 Common Patient Concerns
🔄 Substitutes for clodep 1mg tablet md
View AllAlternative brands with exact same active ingredient:
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clonatrix 1mg tabletZeelab Pharmacy Pvt Ltd ₹10.00 48.6% CHEAPER
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lozep 1mg tabletD D Pharmaceuticals ₹18.53 4.8% CHEAPER
-
clonir 1mg tabletShirr Pharmaceuticals Pvt Ltd ₹19.00 2.4% CHEAPER
-
cloma 1mg tabletSalas Pharmaceuticals ₹20.63 6% COSTLIER
-
klopam 1mg tabletHaryana Formulations Pvt Ltd ₹21.56 10.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe to take for long periods without any risk.
Fact: Long-term use of this medicine can lead to tolerance, dependence, and withdrawal symptoms. It should be used for the shortest duration necessary under medical supervision. - Myth: This medicine can be stopped abruptly once you feel better.
Fact: Stopping this medicine suddenly can cause dangerous withdrawal symptoms, including seizures. It must be tapered gradually under medical guidance. - Myth: This medicine is a good treatment for everyday stress.
Fact: This medicine is not meant for everyday stress. It is prescribed for specific medical conditions and carries risks of dependence and side effects.
🔄 Alternative Options
Generic Alternatives
- Clonazepam 1 mg tablet
Brand Alternatives
- Aplaz 1mg Tablet