clobkare -xl cream

4.8 (13 reviews)

Clobetasol (0.05% w/w)

🏭 Dermakare Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is clobkare -xl cream used for?

Abetanate Cream (Clobetasol) is used to treat DERMA. It contains Clobetasol (0.05% w/w), which Binds to glucocorticoid receptors, modulating gene expression to produce anti-in. Always consult your doctor before use. Take as prescribed.

Generic Name: Clobetasol
Manufacturer: Dermakare Pharmaceuticals Pvt Ltd
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 clobkare -xl cream Uses & Benefits

Treatment of corticosteroid-responsive dermatoses such as psoriasis, eczema, dermatitis, and lichen planus.

Off-label uses: Alopecia areata, Vitiligo, Lichen sclerosus

📋 Drug Information

Generic Name(s)	Clobetasol
Brand Name	Abetanate Cream
Manufacturer	Dermakare Pharmaceuticals Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	DERMA
Action Class	Glucocorticoids
Route of Administration	Topical
Storage	Store at room temperature 20-25°C (68-77°F); keep tightly closed.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionPercutaneous absorption varies; occlusive dressings increase absorption.

DistributionDistributes into skin layers; systemic absorption minimal with topical use.

Protein BindingHighly protein bound (approximately 96-99%)

MetabolismMetabolized in the liver via CYP3A4

Half-LifeNot well defined for topical; systemic half-life ~2-3 hours

ExcretionRenal (urine) and biliary (feces)

BioavailabilityLow systemic bioavailability due to topical application; increased with occlusion or damaged skin.

Onset of ActionWithin a few days of regular application

Peak Plasma TimeNot applicable for topical; systemic levels low

Duration of ActionDuration of effect persists for several hours after application; typically applied twice daily.

How It Works

Binds to glucocorticoid receptors, modulating gene expression to produce anti-inflammatory, antipruritic, and vasoconstrictive effects.

Mechanism Steps

1Clobetasol binds to glucocorticoid receptor (GR) in the cytoplasm.

2The drug-receptor complex translocates to the nucleus.

3Complex binds to glucocorticoid response elements (GREs) on DNA.

💡 How to Take clobkare -xl cream

Follow your doctor's prescription exactly.

⚠️ Side Effects of clobkare -xl cream

✅ Common Side Effects

Burning
itching
irritation
dryness
folliculitis
hypertrichosis
acneiform eruptions
hypopigmentation
perioral dermatitis
allergic contact dermatitis
maceration
secondary infection
skin atrophy
striae
miliaria

🚨 Serious Side Effects

HPA axis suppression
Cushing's syndrome
hyperglycemia
glucosuria
adrenal insufficiency
growth retardation in children
intracranial hypertension
cataracts
glaucoma

⚠️ Rare Side Effects

Kaposi's sarcoma
osteonecrosis
pancreatitis
psychiatric disturbances

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Ketoconazole	Major	Increased systemic corticosteroid levels
Aspirin	Moderate	Increased risk of gastrointestinal bleeding
Live vaccines	Minor	Reduced vaccine efficacy or increased infection risk

🚨 Major Interactions

CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
Anticoagulants (e.g., warfarin)

⚡ Moderate Interactions

NSAIDs
Aspirin
Diuretics

ℹ️ Minor Interactions

Vaccines (live attenuated)
Antidiabetic agents

🍽️ Food Interactions

No significant food interactions

🍷 Alcohol Interaction

No significant interaction

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to clobetasol or any component; untreated bacterial, fungal, or viral skin infections; rosacea; perioral dermatitis; acne vulgaris.

📊 Monitoring Parameters

Monitor for skin atrophy, signs of systemic absorption (e.g., HPA axis suppression), and local adverse reactions.

🤱 Lactation Safety

Use with caution; avoid application to breast area if nursing.

💊 Overdose Management

Topical overdose unlikely; excessive use may cause systemic effects. Discontinue use and treat symptomatically.

⏰ Missed Dose

Apply as soon as remembered; if near next dose, skip missed dose and resume regular schedule. Do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for clobkare -xl cream

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Alternative brands with exact same active ingredient (Clobetasol (0.05% w/w)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Trusted Reviewer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Happy Patient Jul 10, 2026