Clobate GM Cream: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction with swelling of face, lips, or throat, or difficulty breathing.
- Signs of systemic steroid effects such as unusual weight gain, moon face, or easy bruising.
- Severe skin irritation, blistering, or peeling at the application site.
- Signs of a secondary infection such as increased redness, swelling, pain, or pus.
- Symptoms of adrenal crisis including severe fatigue, weakness, dizziness, or low blood pressure.
- No improvement or worsening of the fungal infection after 2 weeks of use.
If experiencing severe symptoms, call emergency services immediately.
What is clobate gm cream used for?
This medicine is a topical cream containing clobetasol (a strong steroid) and miconazole (an antifungal). It is used to treat inflamed fungal skin infections like ringworm and jock itch. Apply a thin layer to the affected area once or twice daily for up to 2 weeks, or as directed by your doctor. Do not use on the face or for prolonged periods without medical advice.
- Generic Name: Clobetasol + Miconazole
- Manufacturer: Laborate Pharmaceuticals India Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 clobate gm cream के बारे में (Hindi Summary)
उपयोग: यह दवा एक टॉपिकल क्रीम है जिसमें क्लोबेटासोल और माइकोनाज़ोल दो सक्रिय तत्व हैं। यह फंगल संक्रमण के साथ-साथ सूजन, खुजली और लालिमा को कम करने में मदद करती है। इसका उपयोग दाद, खाज-खुजली, और पैरों के फंगल संक्रमण के इलाज के लिए किया जाता है। इसे प्रभावित त्वचा पर पतली परत में लगाएं और डॉक्टर के बताए अनुसार ही उपयोग करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में जलन, खुजली, सूखापन, या लालिमा शामिल हैं। लंबे समय तक उपयोग से त्वचा पतली हो सकती है और खिंचाव के निशान पड़ सकते हैं। गंभीर एलर्जी प्रतिक्रिया दुर्लभ है लेकिन तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लगाएं। आंखों, होंठों और म्यूकस मेम्ब्रेन से बचें। चेहरे, जांघों और बगलों पर बिना डॉक्टर की सलाह के न लगाएं। 2 सप्ताह से अधिक उपयोग न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।
💊 clobate gm cream Uses & Benefits
[{"condition":"Tinea corporis (ringworm of the body)","description":"Treats fungal infection of the body skin, reducing itching, redness, and scaling.","evidence":"Well-established"},{"condition":"Tinea cruris (jock itch)","description":"Used for fungal infection of the groin area when inflammation is prominent, but only for short periods and under medical supervision.","evidence":"Well-established"},{"condition":"Tinea pedis (athlete's foot)","description":"Relieves itching, burning, and cracking between toes caused by fungal infection.","evidence":"Well-established"},{"condition":"Inflammatory dermatophytosis","description":"Combination is used when fungal infection is accompanied by significant inflammation or eczematous changes.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Candidal intertrigo","description":"Sometimes used for inflamed yeast infections in skin folds, but only under specialist guidance.","evidence":"Limited"}]
Primary treatment for: Fungal skin infections with inflammation
Also treats: Tinea corporis, Tinea cruris, Tinea pedis, Inflammatory dermatophytosis
📋 Drug Information
| Generic Name(s) | Clobetasol + Miconazole |
| Brand Name | Agmaderm Cream |
| Manufacturer | Laborate Pharmaceuticals India Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | DERMA |
| Action Class | Corticosteroid + Antifungal |
| Route of Administration | Topical |
| Storage | Store below 30°C in a dry place. Do not freeze. Keep the tube tightly closed when not in use. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines a super-potent corticosteroid and an antifungal. Clobetasol binds to glucocorticoid receptors inside skin cells, which reduces the production of inflammatory chemicals and suppresses immune reactions in the skin. This leads to rapid relief of redness, swelling, and itching. Miconazole works by blocking an enzyme called 14-alpha demethylase in fungi, which is needed to make ergosterol, a key component of the fungal cell membrane. Without ergosterol, the fungal cell membrane becomes weak and leaky, causing the fungus to die. The combination addresses both the fungal infection and the associated inflammation.
Mechanism Steps
💡 How to Take clobate gm cream
Strength: Cream containing clobetasol 0.5% w/w and miconazole 2% w/w.
Dosage Information
| Adult Dosage | Apply a thin film of this medicine to the affected skin area once or twice daily, or as directed by your doctor. The duration of treatment depends on the condition and your response. Do not use for more than 2 weeks without medical advice. Dose must be individualized by a qualified clinician based on the indication, severity, and patient factors. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is generally not recommended for children under 12 years due to the risk of systemic absorption and skin thinning. |
| Elderly Dosage | Elderly patients may be more susceptible to skin thinning and systemic effects. Use the smallest effective amount for the shortest duration. Consult a doctor for personalized advice. |
| Renal Impairment | No specific dose adjustment is required for topical use. However, if used on large areas for prolonged periods, monitor for systemic effects in patients with severe renal impairment. |
| Hepatic Impairment | No specific dose adjustment is required for topical use. However, if used on large areas for prolonged periods, monitor for systemic effects in patients with severe hepatic impairment. |
| Maximum Daily Dose | Not established from the available information. Do not exceed the prescribed frequency and duration. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of clobate gm cream
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Oral hypoglycemics | Moderate | |
| Phenytoin | Moderate | |
| Other topical corticosteroids | Major |
🚨 Major Interactions
- Other topical corticosteroids
- Oral anticoagulants (e.g., warfarin)
⚡ Moderate Interactions
- Oral hypoglycemics
- Phenytoin
🍷 Alcohol Interaction
No known interaction between this topical medicine and alcohol. However, alcohol may worsen certain skin conditions or interact with other medicines you are taking. Consult your doctor for personalized advice.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to clobetasol, miconazole, or any component of the cream","Untreated bacterial, viral, or parasitic skin infections","Acne vulgaris, rosacea, perioral dermatitis","Use on the face, groin, or axillae unless specifically directed by a doctor","Children under 12 years unless prescribed by a specialist"]
⚠️ Warnings & Precautions
["For external use only. Do not swallow.","Avoid contact with eyes, lips, and mucous membranes.","Do not use on large areas or for prolonged periods without medical supervision.","Do not cover with tight dressings unless instructed.","If irritation or sensitization occurs, stop use and consult a doctor.","Use with caution in patients with liver disease, diabetes, or immune suppression.","Do not use for more than 2 weeks without medical review."]
🤱 Lactation Safety
It is not known if clobetasol or miconazole pass into breast milk in significant amounts after topical use. However, caution is advised. Do not apply to the breast area before breastfeeding. Consult your doctor before use.
💊 Overdose Management
This medicine is for topical use. Accidental ingestion may cause nausea, vomiting, and systemic steroid effects. Seek immediate medical attention or contact a poison control center. Overuse on the skin can lead to systemic absorption and side effects; wash the area and consult a doctor.
⏰ Missed Dose
If you miss a dose, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Additional Safety Advice
Apply this medicine exactly as prescribed. Do not use it on the face, groin, or underarms unless your doctor specifically tells you to. Avoid contact with eyes, lips, and mucous membranes. Do not cover the treated area with tight bandages or dressings unless instructed. Wash your hands before and after application. Do not use this medicine for longer than the prescribed duration, as prolonged use increases the risk of side effects. If you are pregnant, planning pregnancy, or breastfeeding, inform your doctor before using this medicine. Keep this medicine out of reach of children. Do not share this medicine with others, even if they have similar symptoms. If your condition does not improve within two weeks or worsens, contact your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to skin thinning and systemic effects from topical corticosteroids. Use the smallest effective amount for the shortest duration. Monitor for signs of skin atrophy and systemic effects.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. Topical corticosteroids should be used with caution during pregnancy. Use the smallest amount for the shortest duration.
🏥 Post-Surgery Considerations
Consult your doctor before using this medicine on surgical wounds or nearby skin. It may interfere with wound healing or increase the risk of infection.
🦷 Dental Procedures
This medicine is for skin use only and does not affect dental procedures. However, inform your dentist about all medicines you are using.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You can continue exercising, but avoid activities that cause excessive sweating or friction on the affected area. Shower immediately after exercise and dry the area thoroughly. Wear clean, breathable clothing.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is applied to the skin and is unlikely to affect your ability to drive or operate machinery. However, if you experience any dizziness or unusual symptoms, avoid these activities until you feel better. You can continue your normal daily activities while using this medicine.
🛑 When to Stop This Medicine
Stop using this medicine and consult your doctor if your symptoms do not improve within 2 weeks, if they worsen, or if you experience severe irritation or an allergic reaction. Do not stop early without completing the prescribed course, as the infection may return.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to skin thinning, stretch marks, and increased hair growth. It can also cause systemic steroid effects such as high blood sugar, high blood pressure, and adrenal suppression, especially if used on large areas for prolonged periods. Regular monitoring by a doctor is recommended if long-term use is necessary. Do not use for more than 2 weeks without medical review.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For mild fungal infections without significant inflammation, a plain antifungal cream may be sufficient.
Evidence: Well-establishedFor extensive or resistant infections, oral antifungal medicines may be prescribed by a doctor.
Evidence: Well-establishedKeeping the skin clean and dry helps prevent fungal infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interaction between this topical medicine and vaccines. However, if you are using this medicine on large areas for a long time, it may suppress the immune system slightly. Consult your doctor before receiving any live vaccines.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case customs officials ask for it. Store it in a cool, dry place away from direct sunlight. If you are traveling across time zones, continue applying the cream at your usual times; topical medicines do not require strict time zone adjustments. Keep it in your carry-on luggage if you need it during the flight, but ensure it complies with airline liquid regulations. Do not leave it in a hot car or checked luggage where temperatures may fluctuate.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Itching and redness may start to improve within a few hours to a day. The fungal infection may take several days to weeks to clear completely. Complete the full course as prescribed.
A: No, unless your doctor specifically tells you to. The face is more sensitive and prone to side effects like skin thinning.
A: Use only if clearly needed and under medical supervision. Topical corticosteroids should be used in the smallest amount for the shortest duration.
A: Apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose.
🤔 Common Patient Concerns
🔄 Substitutes for clobate gm cream
View AllAlternative brands with exact same active ingredient:
-
cloberuth m creamRut Pharma Pvt Ltd ₹38.00 36.7% CHEAPER
-
anicob creamAnisum Lifesciences ₹70.00 16.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This cream can be used for any skin rash.
Fact: It is only for fungal infections with inflammation. Using it for other rashes can worsen the condition. - Myth: More cream means faster healing.
Fact: Applying more than a thin film does not speed healing and increases the risk of side effects. - Myth: It is safe to use for months.
Fact: Prolonged use can cause skin thinning, stretch marks, and systemic effects. Use only as prescribed, usually for up to 2 weeks.
🔄 Alternative Options
Generic Alternatives
- Clobetasol + Miconazole cream (generic)
Brand Alternatives
- Clobate GM
- Clobate-GM
- Clobetasol+Miconazole Cream