clear granules

4.5 (10 reviews)

Clarithromycin (125mg)

🏭 Alkem Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is clear granules used for?

Acnesol CL Gel (Clarithromycin) is used to treat ANTI INFECTIVES. It contains Clarithromycin (125mg), which Binds to 50S ribosomal subunit of bacteria, inhibiting protein synthesis.. Always consult your doctor before use. Take as prescribed.

Generic Name: Clarithromycin
Manufacturer: Alkem Laboratories Ltd
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 clear granules Uses & Benefits

Acne vulgaris

Off-label uses: Bacterial skin infections, Rosacea

📋 Drug Information

Generic Name(s)	Clarithromycin
Brand Name	Acnesol CL Gel
Manufacturer	Alkem Laboratories Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI INFECTIVES
Action Class	Macrolides
Route of Administration	Topical
Storage	Store at room temperature (20-25°C); protect from light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionTopical absorption is minimal; systemic absorption is low when applied to intact skin.

DistributionNot well characterized for topical use; systemic distribution follows oral administration.

Protein BindingApproximately 70% bound to plasma proteins.

MetabolismMetabolized in the liver via CYP3A4 isoenzyme to active metabolite 14-hydroxyclarithromycin.

Half-Life3-4 hours for parent drug; 5-6 hours for active metabolite.

ExcretionPrimarily excreted in urine (20-30% as unchanged drug) and feces.

BioavailabilityNot applicable for topical formulation; oral bioavailability is ~50%.

Onset of ActionWithin a few days of topical application.

Peak Plasma TimeNot applicable for topical use; oral peak at 2-3 hours.

Duration of ActionNot well defined for topical use; typically applied twice daily.

How It Works

Binds to 50S ribosomal subunit of bacteria, inhibiting protein synthesis.

Mechanism Steps

1Clarithromycin binds to the 50S ribosomal subunit of susceptible bacteria.

2Inhibits translocation of peptidyl-tRNA.

3Blocks protein synthesis, leading to bacteriostatic effect.

💡 How to Take clear granules

Follow your doctor's prescription exactly.

⚠️ Side Effects of clear granules

✅ Common Side Effects

Skin irritation
Dryness
Peeling
Redness

🚨 Serious Side Effects

Severe allergic reaction
Stevens-Johnson syndrome

⚠️ Rare Side Effects

Pseudomembranous colitis
Hepatotoxicity

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Cisapride	Major	Increased risk of cardiac arrhythmias
Pimozide	Major	Increased risk of QT prolongation
Ergotamine	Major	Increased risk of ergotism
Lovastatin	Major	Increased risk of rhabdomyolysis
Simvastatin	Major	Increased risk of rhabdomyolysis
Warfarin	Moderate	Increased INR and bleeding risk
Theophylline	Moderate	Increased theophylline levels
Carbamazepine	Moderate	Increased carbamazepine levels
Digoxin	Moderate	Increased digoxin levels
Oral contraceptives	Moderate	Reduced contraceptive efficacy
Zidovudine	Minor	Decreased zidovudine levels
Phenytoin	Minor	Altered phenytoin levels
Valproate	Minor	Decreased valproate levels

🚨 Major Interactions

Cisapride
Pimozide
Ergotamine
Lovastatin
Simvastatin

⚡ Moderate Interactions

Warfarin
Theophylline
Carbamazepine
Digoxin
Oral contraceptives

ℹ️ Minor Interactions

Zidovudine
Phenytoin
Valproate

🍽️ Food Interactions

No significant food interactions for topical use.

🍷 Alcohol Interaction

No known interaction with topical use.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to clarithromycin or macrolides; concurrent use with cisapride, pimozide, ergotamine.

📊 Monitoring Parameters

Clinical response; skin irritation.

🤱 Lactation Safety

Use with caution; excreted in breast milk.

💊 Overdose Management

Topical overdose unlikely; if ingested, symptomatic treatment.

⏰ Missed Dose

Apply as soon as remembered; skip if almost time for next dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

🔗 View Profile

🔄 Substitutes for clear granules

View All

Alternative brands with exact same active ingredient (Clarithromycin (125mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Certified Buyer Jul 10, 2026

Found this to be a helpful product. Good results.

Regular Customer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Happy Patient Jul 10, 2026

Effective and reliable. Worked as expected.