clarbact 250 tablet - Clarithromycin (250mg) medicine

clarbact 250 tablet

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🏭 Ipca Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is clarbact 250 tablet used for?

This medicine contains Clarithromycin (250mg) and is used to treat ANTI INFECTIVES. Binds to 50S ribosomal subunit of bacteria, inhibiting protein synthesis.. Always consult your doctor before use.

  • Generic Name: Clarithromycin
  • Manufacturer: Ipca Laboratories Ltd
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 clarbact 250 tablet Uses & Benefits

Acne vulgaris

Off-label uses: Bacterial skin infections, Rosacea

📋 Drug Information

Generic Name(s)Clarithromycin
Brand NameAcnesol CL Gel
ManufacturerIpca Laboratories Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassMacrolides
Route of AdministrationTopical
StorageStore at room temperature (20-25°C); protect from light.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionTopical absorption is minimal; systemic absorption is low when applied to intact skin.
DistributionNot well characterized for topical use; systemic distribution follows oral administration.
Protein BindingApproximately 70% bound to plasma proteins.
MetabolismMetabolized in the liver via CYP3A4 isoenzyme to active metabolite 14-hydroxyclarithromycin.
Half-Life3-4 hours for parent drug; 5-6 hours for active metabolite.
ExcretionPrimarily excreted in urine (20-30% as unchanged drug) and feces.
BioavailabilityNot applicable for topical formulation; oral bioavailability is ~50%.
Onset of ActionWithin a few days of topical application.
Peak Plasma TimeNot applicable for topical use; oral peak at 2-3 hours.
Duration of ActionNot well defined for topical use; typically applied twice daily.

How It Works

Binds to 50S ribosomal subunit of bacteria, inhibiting protein synthesis.

Mechanism Steps

1Clarithromycin binds to the 50S ribosomal subunit of susceptible bacteria.
2Inhibits translocation of peptidyl-tRNA.
3Blocks protein synthesis, leading to bacteriostatic effect.

💡 How to Take clarbact 250 tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of clarbact 250 tablet

✅ Common Side Effects

Skin irritation
Dryness
Peeling
Redness

🚨 Serious Side Effects

Severe allergic reaction
Stevens-Johnson syndrome

⚠️ Rare Side Effects

Pseudomembranous colitis
Hepatotoxicity

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Cisapride Major Increased risk of cardiac arrhythmias
Pimozide Major Increased risk of QT prolongation
Ergotamine Major Increased risk of ergotism
Lovastatin Major Increased risk of rhabdomyolysis
Simvastatin Major Increased risk of rhabdomyolysis
Warfarin Moderate Increased INR and bleeding risk
Theophylline Moderate Increased theophylline levels
Carbamazepine Moderate Increased carbamazepine levels
Digoxin Moderate Increased digoxin levels
Oral contraceptives Moderate Reduced contraceptive efficacy
Zidovudine Minor Decreased zidovudine levels
Phenytoin Minor Altered phenytoin levels
Valproate Minor Decreased valproate levels

🚨 Major Interactions

  • Cisapride
  • Pimozide
  • Ergotamine
  • Lovastatin
  • Simvastatin

⚡ Moderate Interactions

  • Warfarin
  • Theophylline
  • Carbamazepine
  • Digoxin
  • Oral contraceptives

🍷 Alcohol Interaction

No known interaction with topical use.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to clarithromycin or macrolides; concurrent use with cisapride, pimozide, ergotamine.

🤱 Lactation Safety

Use with caution; excreted in breast milk.

💊 Overdose Management

Topical overdose unlikely; if ingested, symptomatic treatment.

⏰ Missed Dose

Apply as soon as remembered; skip if almost time for next dose.

🔄 Substitutes for clarbact 250 tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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