Alkatis Syrup: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in urine or stool
- Severe abdominal pain
- Chest pain or difficulty breathing
- Swelling of the face, lips, or throat
- Confusion or weakness
- Decreased urine output
- Irregular heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is citroza syrup used for?
This medicine is an oral syrup containing disodium hydrogen citrate, used to make urine less acidic. It helps relieve burning during urinary tract infections and prevents uric acid and cystine kidney stones. It is not an antibiotic and should be taken exactly as prescribed.
- Generic Name: Disodium Hydrogen Citrate
- Manufacturer: Pramukh Swami Pharma Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 citroza syrup के बारे में (Hindi Summary)
उपयोग: यह दवा मूत्र पथ के संक्रमण में जलन और दर्द को कम करने के लिए दी जाती है। यह पेशाब को कम अम्लीय बनाती है, जिससे यूरिक एसिड और सिस्टीन की पथरी बनने से रोकती है और मौजूद पथरी को घोलने में मदद करती है। यह एंटीबायोटिक नहीं है, इसलिए संक्रमण के इलाज के लिए डॉक्टर द्वारा बताई गई एंटीबायोटिक भी लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में हल्का पेट दर्द, जी मिचलाना, दस्त, मुँह में नमकीन स्वाद और प्यास लगना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। कभी-कभी पैरों में सूजन, एलर्जी, या खून में सोडियम की मात्रा बढ़ सकती है। गंभीर लक्षण जैसे साँस लेने में कठिनाई, चेहरे या गले में सूजन हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे एक गिलास पानी में मिलाकर पिएँ। दिनभर पर्याप्त पानी पिएँ। अगर आपको हाई ब्लड प्रेशर, हृदय रोग, गुर्दे की बीमारी या नमक कम खाने की सलाह है, तो डॉक्टर को बताएं। एल्युमिनियम या कैल्शियम वाले एंटासिड के साथ इस दवा को न लें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। बिना डॉक्टर की सलाह के लंबे समय तक इसका इस्तेमाल न करें।
💊 citroza syrup Uses & Benefits
[{"condition":"Urinary tract infections (cystitis, urethritis)","description":"This medicine helps relieve the burning and stinging sensation during urination by making the urine less acidic.","evidence":"Well-established"},{"condition":"Uric acid kidney stones","description":"It alkalinizes the urine, which helps dissolve uric acid stones and prevents new ones from forming.","evidence":"Well-established"},{"condition":"Cystine kidney stones","description":"Used to increase urine pH, which helps dissolve cystine stones and prevent their recurrence.","evidence":"Well-established"},{"condition":"Metabolic acidosis (mild to moderate)","description":"Sometimes used to correct mild metabolic acidosis by providing an alkali load.","evidence":"Limited"},{"condition":"Chemotherapy-induced urinary discomfort","description":"May be used to reduce bladder irritation caused by certain chemotherapy drugs.","evidence":"Limited"}]
Off-label uses: [{"condition":"Gout","description":"Sometimes used off-label to alkalinize urine and help excrete uric acid in patients with gout.","evidence":"Limited"},{"condition":"Prevention of contrast-induced nephropathy","description":"Rarely used off-label to alkalinize urine before contrast procedures, but evidence is weak.","evidence":"Limited"}]
Primary treatment for: Urinary tract infections and kidney stones
Also treats: Cystitis, Urethritis, Uric acid stones, Cystine stones, Metabolic acidosis
📋 Drug Information
| Generic Name(s) | Disodium Hydrogen Citrate |
| Brand Name | Alkasol Oral Solution |
| Manufacturer | Pramukh Swami Pharma Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | UROLOGY |
| Action Class | Uricosuric agent-gout |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Do not refrigerate. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by providing citrate ions that are metabolized in the body to bicarbonate. Bicarbonate is an alkali that neutralizes excess acid in the urine, raising the urinary pH. This alkalinization makes the urine less acidic, which helps dissolve uric acid and cystine stones and reduces the irritation of the bladder lining during urinary tract infections. It does not kill bacteria, so it is not a substitute for antibiotics when an infection is present.
Mechanism Steps
💡 How to Take citroza syrup
Strength: Syrup containing disodium hydrogen citrate 1.4 g per 5 mL.
Dosage Information
| Adult Dosage | The usual adult dose is 10 to 15 mL of syrup (containing 1.4 g disodium hydrogen citrate per 5 mL) mixed with a full glass of water, taken 3 to 4 times daily after meals. The exact dose and frequency must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the sodium content and fluid retention effects. Dose should be individualized by a clinician, and kidney function and electrolytes should be monitored regularly. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary based on kidney function. Consult a doctor. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Consult a doctor. |
| Maximum Daily Dose | The maximum daily dose is not established from the available information. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of citroza syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Aluminium-containing antacids | Major | |
| Lithium | Major | |
| Salicylates | Major | |
| Tetracycline antibiotics | Moderate | |
| Quinolone antibiotics | Moderate | |
| Methenamine | Moderate | |
| Amphetamines | Minor | |
| Ephedrine | Minor |
🚨 Major Interactions
- Aluminium-containing antacids
- Lithium
- Salicylates (e.g., aspirin)
⚡ Moderate Interactions
- Tetracycline antibiotics
- Quinolone antibiotics
- Methenamine
🍷 Alcohol Interaction
Alcohol may increase the risk of stomach upset and dehydration. It is best to avoid alcohol while taking this medicine, especially if you have a urinary tract infection or kidney stones.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe kidney disease","Severe heart failure","Uncontrolled high blood pressure","Hypernatremia","Metabolic alkalosis","Known allergy to disodium hydrogen citrate"]
⚠️ Warnings & Precautions
["Use with caution in patients with heart disease or hypertension due to sodium content.","Monitor electrolyte levels during prolonged use.","Avoid concurrent use with aluminium-containing antacids.","Do not use to treat urinary tract infections without antibiotics.","Consult a doctor if symptoms persist or worsen.","Keep out of reach of children."]
🤱 Lactation Safety
It is not known whether disodium hydrogen citrate passes into breast milk. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose may cause metabolic alkalosis, hypernatremia, and fluid overload. Seek immediate medical attention. Treatment is supportive and may include intravenous fluids and electrolyte correction.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Always take this medicine exactly as your doctor has prescribed. Do not increase or decrease the dose on your own. Mix the syrup with a full glass of water unless your doctor tells you otherwise. Drink plenty of water throughout the day to help the medicine work better and to prevent dehydration. If you have high blood pressure, heart failure, kidney disease, or are on a low-sodium diet, tell your doctor before starting this medicine. Avoid taking antacids or other medicines that contain aluminium or calcium at the same time, as they can reduce the effect of this medicine. Do not take this medicine if you are allergic to disodium hydrogen citrate or any of the other ingredients. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep all follow-up appointments so your doctor can monitor your electrolyte levels and kidney function. Do not use this medicine for longer than recommended without medical supervision.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to electrolyte imbalances and fluid retention due to reduced kidney function. Use with caution and monitor electrolytes and kidney function regularly. The sodium content may worsen heart failure or hypertension.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before using this medicine. The safety of this medicine during pregnancy is not well established. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
This medicine may be used after surgery to alkalinize urine and prevent stone formation, especially in patients with a history of kidney stones. Consult your surgeon before using it.
🦷 Dental Procedures
No specific precautions are needed for dental procedures. However, inform your dentist about all medicines you are taking.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
There are no specific exercise restrictions while taking this medicine. However, if you have kidney stones or a urinary tract infection, avoid strenuous activities that may worsen pain. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine generally does not affect your ability to drive or operate machinery. However, if you experience dizziness or stomach upset, avoid driving until you feel better. It may cause frequent urination, so plan your work schedule accordingly.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms worsen, contact your doctor immediately. Your doctor will advise you on when and how to stop based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to electrolyte imbalances, such as high sodium or bicarbonate levels, and fluid retention. It may also increase the risk of calcium phosphate kidney stones. Regular monitoring of urinary pH, serum electrolytes, and kidney function is recommended during prolonged therapy. Do not use for extended periods without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Drinking plenty of water helps dilute urine and prevent stone formation.
Evidence: Well-establishedReducing sodium, animal protein, and oxalate-rich foods can help prevent kidney stones.
Evidence: Well-establishedAnother urinary alkalinizer that may be used as an alternative.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. Continue with your regular vaccination schedule as advised by your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or doctor's note, especially for international travel. Store it at room temperature and protect it from direct sunlight. If you are traveling across time zones, continue taking your doses at regular intervals as prescribed. Keep enough supply for your entire trip. Check customs regulations for carrying liquid medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts alkalinizing urine within 1 to 2 hours after taking a dose. Symptom relief may be felt within a day or two, but complete effect depends on the underlying condition.
A: Yes, it is often prescribed alongside antibiotics for urinary tract infections. However, it may interact with certain antibiotics like tetracyclines and quinolones. Inform your doctor about all medicines you are taking.
A: It is generally safe when used as prescribed. However, it should be used with caution in people with kidney disease. Your doctor may monitor your kidney function and electrolytes.
A: Consult your doctor before using this medicine during pregnancy. The safety profile is not well established.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for citroza syrup
View AllAlternative brands with exact same active ingredient:
-
citra ion syrupBindlysh Biotec Ltd ₹24.84 6% COSTLIER
-
Medicitron SyrupMedi Products Pvt Ltd ₹27.66 18% COSTLIER
-
alkcit 1.4gm syrupGood Luck Pharmaceuticals ₹28.00 19.5% COSTLIER
-
jucitron syrupUniversal Medikit ₹29.53 26% COSTLIER
-
altos syrupSanto Formulations ₹30.00 28% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure urinary tract infections on its own.
Fact: This medicine only relieves symptoms by alkalinizing urine. It does not kill bacteria. Antibiotics are needed to treat the infection. - Myth: It is safe to take this medicine indefinitely without monitoring.
Fact: Long-term use requires monitoring of electrolytes and kidney function. Do not use for prolonged periods without medical supervision. - Myth: This medicine is a painkiller.
Fact: It is not a painkiller. It reduces burning by making urine less acidic, but it does not relieve pain from other causes.
🔄 Alternative Options
Generic Alternatives
- Disodium hydrogen citrate syrup
Brand Alternatives
- Alkatis Syrup