cilnione m 10mg/25mg tablet
What is cilnione m 10mg/25mg tablet used for?
Arbitel-Trio 50 Tablet ER (Cilnidipine + Metoprolol Succinate) is used to treat CARDIAC. It contains Cilnidipine (10mg) + Metoprolol Succinate (25mg), which Cilnidipine: Blocks L-type and N-type calcium channels, reducing calcium influx . Always consult your doctor before use. Take as prescribed.
- Generic Name: Cilnidipine + Metoprolol Succinate
- Manufacturer: Oswin Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cilnione m 10mg/25mg tablet Uses & Benefits
Off-label uses: Angina, arrhythmias (metoprolol component)
๐ Drug Information
| Generic Name(s) | Cilnidipine + Metoprolol Succinate |
| Brand Name | Arbitel-Trio 50 Tablet ER |
| Manufacturer | Oswin Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Antihypertensive combination (Calcium channel blocker + Beta-blocker) |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cilnidipine: Blocks L-type and N-type calcium channels, reducing calcium influx in vascular smooth muscle and sympathetic nerve endings; Metoprolol: Selective beta-1 blocker, reduces heart rate and contractility
Mechanism Steps
๐ก How to Take cilnione m 10mg/25mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cilnione m 10mg/25mg tablet
โ Common Side Effects
- Dizziness
- Fatigue
- Headache
- Edema
- Bradycardia
- Nausea
๐จ Serious Side Effects
- Heart block
- Severe bradycardia
- Hypotension
- Bronchospasm
- Heart failure exacerbation
โ ๏ธ Rare Side Effects
- Thrombocytopenia
- Hepatitis
- Stevens-Johnson syndrome
- Lupus-like syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Verapamil | Major | Increased risk of bradycardia and heart block |
| Diltiazem | Major | Additive negative chronotropic effects |
| Clonidine | Major | Rebound hypertension on withdrawal |
| Digoxin | Major | Increased digoxin levels and bradycardia |
| Amiodarone | Major | Increased risk of bradycardia and QT prolongation |
| Ketoconazole | Moderate | Increased cilnidipine levels |
| Fluoxetine | Moderate | Increased metoprolol levels |
| NSAIDs | Moderate | Reduced antihypertensive effect |
| Antidiabetic agents | Moderate | Masking of hypoglycemia symptoms |
| Cimetidine | Minor | Slight increase in metoprolol levels |
| Rifampin | Minor | Decreased cilnidipine levels |
๐จ Major Interactions
- Verapamil
- Diltiazem
- Clonidine
- Digoxin
- Amiodarone
โก Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP2D6 inhibitors (e.g., fluoxetine)
- NSAIDs
- Antidiabetic agents
โน๏ธ Minor Interactions
- Cimetidine
- Rifampin
- Alcohol
๐ฝ๏ธ Food Interactions
Avoid grapefruit juice (increases cilnidipine levels); take with or without food
๐ท Alcohol Interaction
May enhance hypotensive effect; avoid excessive alcohol
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Sinus bradycardia, heart block (2nd/3rd degree), cardiogenic shock, decompensated heart failure, sick sinus syndrome, severe hypotension, hypersensitivity
๐ Monitoring Parameters
Blood pressure, heart rate, ECG, blood glucose (in diabetics)
๐คฑ Lactation Safety
Cilnidipine: Not recommended; Metoprolol: Excreted in milk, use with caution
๐ Overdose Management
Supportive care: atropine for bradycardia, vasopressors for hypotension, calcium gluconate for calcium channel blocker overdose
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Effective and reliable. Worked as expected.
This medicine was effective for me. I followed the doctor's advice.
Effective and reliable. Worked as expected.
Helpful and effective medicine as per my experience. Always consult a doctor.
Good quality medicine. Satisfied with the outcome.