cilnicue-t tablet - Uses, Price, Side Effects & Substitutes
What is cilnicue-t tablet used for?
Acmetel-LN Tablet (Cilnidipine + Telmisartan) is used to treat CARDIAC. It contains Cilnidipine (10mg) + Telmisartan (40mg), which Cilnidipine: Inhibits calcium influx through L-type and N-type calcium channels,. Always consult your doctor before use. Take as prescribed.
- Generic Name: Cilnidipine + Telmisartan
- Manufacturer: Cue Labs
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cilnicue-t tablet Uses & Benefits
Hypertension (essential hypertension).
Off-label uses: Chronic kidney disease (with proteinuria), heart failure (limited data).
๐ Drug Information
| Generic Name(s) | Cilnidipine + Telmisartan |
| Brand Name | Acmetel-LN Tablet |
| Manufacturer | Cue Labs |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Calcium channel blocker + Angiotensin II receptor blocker |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cilnidipine: Inhibits calcium influx through L-type and N-type calcium channels, causing vasodilation and reduced blood pressure; Telmisartan: Blocks angiotensin II type 1 (AT1) receptors, leading to vasodilation and reduced aldosterone secretion.
Mechanism Steps
๐ก How to Take cilnicue-t tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cilnicue-t tablet
โ Common Side Effects
- Dizziness
- Headache
- Peripheral edema
- Fatigue
- Diarrhea
๐จ Serious Side Effects
- Angioedema
- Syncope
- Acute renal failure
- Hyperkalemia
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Thrombocytopenia
- Interstitial pneumonitis
- Anaphylaxis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Lithium | Major | Increased lithium levels and toxicity |
| Potassium-sparing diuretics | Major | Increased risk of hyperkalemia |
| NSAIDs | Moderate | Reduced antihypertensive effect and increased renal risk |
| CYP3A4 inhibitors | Moderate | Increased cilnidipine levels |
| Digoxin | Moderate | Increased digoxin levels |
| Warfarin | Minor | Minimal effect on INR |
๐จ Major Interactions
- Lithium
- Potassium-sparing diuretics
- ACE inhibitors
- Aliskiren
โก Moderate Interactions
- NSAIDs
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP3A4 inducers (e.g., rifampin)
- Digoxin
โน๏ธ Minor Interactions
- Antacids
- Warfarin
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase cilnidipine levels; high-fat meals may reduce telmisartan absorption.
๐ท Alcohol Interaction
May potentiate hypotensive effects; avoid excessive alcohol.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity; pregnancy; bilateral renal artery stenosis; severe hepatic impairment; concomitant use with aliskiren in diabetes.
๐ Monitoring Parameters
Blood pressure, heart rate, serum potassium, renal function, liver function.
๐คฑ Lactation Safety
Not recommended; avoid breastfeeding.
๐ Overdose Management
Symptomatic and supportive treatment; monitor blood pressure and heart rate; consider gastric lavage if recent ingestion.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose.