Avim C 500mg/500mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Seizures or unusual muscle twitching
- Severe or bloody diarrhea
- Yellowing of the skin or eyes
- Decreased urine output or swelling in the legs
- Severe skin rash with blisters or peeling
- High fever with chills that do not improve
If experiencing severe symptoms, call emergency services immediately.
What is cilamin 500mg/500mg injection used for?
This medicine is a combination antibiotic containing imipenem and cilastatin, used intravenously to treat serious bacterial infections. It works by killing bacteria and preventing kidney breakdown of the antibiotic.
- Generic Name: Imipenem + Cilastatin
- Manufacturer: Medi Biotech Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cilamin 500mg/500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक शक्तिशाली एंटीबायोटिक है जिसका उपयोग गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है, जैसे कि पेट के अंदर के संक्रमण, निमोनिया, मूत्र पथ के संक्रमण, त्वचा के संक्रमण और रक्त के संक्रमण। यह इमिपेनम और सिलास्टेटिन का संयोजन है और इसे केवल अस्पताल में नस के माध्यम से दिया जाता है। यह वायरल संक्रमण जैसे सर्दी-जुकाम के लिए प्रभावी नहीं है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, दाने, बुखार और इंजेक्शन स्थल पर दर्द शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, दौरे, गंभीर दस्त और गुर्दे की समस्या शामिल हो सकती है। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा नस के माध्यम से दी जाती है। इसे स्वयं न लें। अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों, विशेषकर गुर्दे की बीमारी, दौरे की समस्या या एंटीबायोटिक एलर्जी के बारे में बताएं। इलाज के दौरान शराब न पिएं। यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर दाने हों तो तुरंत आपातकालीन चिकित्सा सहायता लें।
💊 cilamin 500mg/500mg injection Uses & Benefits
[{"condition":"Complicated intra-abdominal infections","description":"Used to treat serious infections within the abdomen, such as peritonitis and abscesses, often caused by mixed bacteria.","evidence":"Well-established"},{"condition":"Severe pneumonia","description":"Effective against hospital-acquired and ventilator-associated pneumonia caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Treats severe kidney and urinary tract infections, including pyelonephritis.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for complicated skin infections, including those caused by multidrug-resistant bacteria.","evidence":"Well-established"},{"condition":"Bloodstream infections","description":"Treats sepsis and bacteremia caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Used as empirical therapy in cancer patients with low white blood cell counts and fever.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Melioidosis","description":"Sometimes used off-label for treating melioidosis, a bacterial infection caused by Burkholderia pseudomallei, based on susceptibility.","evidence":"Limited"},{"condition":"Nocardiosis","description":"May be used off-label for nocardiosis, a rare bacterial infection, when other treatments are not suitable.","evidence":"Limited"}]
Primary treatment for: Serious bacterial infections
Also treats: Complicated intra-abdominal infections, Hospital-acquired pneumonia, Complicated urinary tract infections, Skin and soft tissue infections, Sepsis, Febrile neutropenia
📋 Drug Information
| Generic Name(s) | Imipenem + Cilastatin |
| Brand Name | Avim C 500mg/500mg Injection |
| Manufacturer | Medi Biotech Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Carbapenem antibiotic with renal dehydropeptidase inhibitor |
| Route of Administration | Intravenous (IV) infusion only. Administer over 30-60 minutes. Do not administer as a rapid bolus |
| Storage | Store the unreconstituted vial at 20-25°C (68-77°F). After reconstitution, the solution should be used immediately or stored as per manufacturer's instructions. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Imipenem, the active antibacterial component of this medicine, works by inhibiting the synthesis of the bacterial cell wall. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, preventing the cross-linking of peptidoglycan chains, which is essential for cell wall strength and rigidity. This leads to bacterial cell lysis and death. Cilastatin is a renal dehydropeptidase inhibitor that blocks the enzyme responsible for breaking down imipenem in the kidneys, thereby increasing the concentration of active imipenem in the urine and reducing the potential for kidney toxicity.
Mechanism Steps
💡 How to Take cilamin 500mg/500mg injection
Strength: 500 mg imipenem / 500 mg cilastatin per vial, intravenous injection.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 500 mg imipenem/500 mg cilastatin administered intravenously every 6 hours for severe infections. For less severe infections, 250 mg/250 mg every 6 hours may be used. The maximum daily dose is 4 g (imipenem component). Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. For patients with renal impairment, dose reduction is required. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. For children over 3 months, doses are typically based on weight and severity of infection, but must be determined by a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function; dose should be adjusted based on creatinine clearance. No specific dose adjustment is recommended solely based on age, but renal function should be monitored. |
| Renal Impairment | Dose adjustment is required for patients with renal impairment. For creatinine clearance 20-40 mL/min, reduce dose to 250-500 mg every 6-8 hours. For creatinine clearance <20 mL/min, reduce dose to 250 mg every 12 hours. For patients on hemodialysis, administer after dialysis. Consult a clinician for precise dosing. |
| Hepatic Impairment | No specific dose adjustment is recommended for hepatic impairment. However, monitor liver function during therapy. |
| Maximum Daily Dose | 4 g per day (imipenem component) in adults with normal renal function. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cilamin 500mg/500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ganciclovir | Major | |
| Valproic acid | Major | |
| Probenecid | Moderate | |
| Cyclosporine | Moderate | |
| Aminoglycosides | Moderate | |
| Warfarin | Moderate |
🚨 Major Interactions
- Ganciclovir
- Valproic acid
- Probenecid
⚡ Moderate Interactions
- Cyclosporine
- Aminoglycosides
- Warfarin
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. It may lower the seizure threshold and increase the risk of seizures, as well as worsen nausea, vomiting, and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to imipenem, cilastatin, or other carbapenem antibiotics","History of severe allergic reaction to penicillins or cephalosporins","Severe renal impairment without dose adjustment","Concurrent use with ganciclovir (increased seizure risk)","Patients with a history of seizures (relative contraindication; use with caution)"]
⚠️ Warnings & Precautions
["Serious allergic reactions, including anaphylaxis, have been reported. Discontinue immediately if allergic reaction occurs.","Seizures have been reported, especially in patients with renal impairment or CNS disorders. Adjust dose in renal impairment.","Clostridioides difficile-associated diarrhea may occur. Use caution in patients with a history of colitis.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","May interfere with certain laboratory tests (e.g., urine glucose tests).","Safety and effectiveness in children under 3 months have not been established."]
🤱 Lactation Safety
Imipenem and cilastatin are excreted in human milk in low amounts. Caution is advised when administering to a nursing mother. Consult your doctor to weigh benefits and risks.
💊 Overdose Management
Overdose with this medicine is unlikely due to its intravenous administration in a controlled setting. In case of overdose, discontinue infusion and provide supportive care. Imipenem and cilastatin are removed by hemodialysis. Monitor vital signs and renal function closely.
⏰ Missed Dose
This medicine is administered by a healthcare professional in a hospital setting. If a dose is missed, it should be given as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Additional Safety Advice
This medicine must be administered only by a healthcare professional in a hospital or clinic setting. Do not attempt to self-administer. Inform your doctor about all your medical conditions, especially kidney disease, seizure disorders, or allergies to antibiotics. Your doctor will monitor your kidney function, liver function, and blood counts during treatment. Avoid alcohol while receiving this medicine as it may worsen side effects. If you experience signs of a severe allergic reaction such as difficulty breathing, swelling of the face or throat, or a severe rash, seek emergency medical help immediately. Do not stop treatment early even if you feel better, as this can lead to antibiotic resistance and recurrence of infection.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function and may require dose adjustment. They are also at higher risk of seizures and should be monitored closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting this medicine. It is classified as Pregnancy Category B, meaning it should be used only if clearly needed. Discuss risks and benefits with your healthcare provider.
🏥 Post-Surgery Considerations
This medicine is often used after surgery to prevent or treat infections. It is administered intravenously in the hospital. Follow your surgeon's instructions regarding wound care and monitoring for signs of infection.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It may interact with other medications used during dental procedures. No specific precautions are required, but maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while receiving this medicine, as you may feel weak or dizzy. Light activity is fine if you feel up to it, but consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so you will need to be admitted or visit the hospital for infusions. You should not drive or operate machinery if you feel dizzy or have seizures. Plan for time off work during treatment.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early can lead to incomplete treatment and antibiotic resistance. Your doctor will decide when to stop based on your clinical response and culture results.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, superinfections with fungi or resistant bacteria, and rarely, blood disorders or liver toxicity. Prolonged therapy should be guided by clinical response and culture results. Regular monitoring of kidney and liver function is recommended.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another carbapenem antibiotic with similar spectrum but lower seizure risk.
Evidence: Well-establishedA beta-lactam/beta-lactamase inhibitor combination for serious infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, live vaccines should be avoided during antibiotic therapy as the immune response may be reduced. Consult your doctor before receiving any vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered in a hospital setting, so travel is not applicable. If you are discharged with a prescription for home infusion, ensure you carry the medicine in its original packaging with the prescription. Keep it at room temperature and protect it from light. Check with your airline for carrying injectable medicines. Always carry a doctor's note explaining your medical condition and the need for this medicine.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 minutes to 1 hour after infusion, but you may not feel better immediately. Improvement in symptoms usually occurs within 48 to 72 hours.
A: No, this medicine is only available as an intravenous injection and must be given by a healthcare professional.
A: Cilastatin in this medicine helps protect the kidneys from imipenem. However, kidney function should be monitored, especially if you have pre-existing kidney disease.
🤔 Common Patient Concerns
🔄 Substitutes for cilamin 500mg/500mg injection
View AllAlternative brands with exact same active ingredient:
-
imilan 500mg/500mg injectionMylan Pharmaceuticals Pvt Ltd ₹467.81 67.5% CHEAPER
-
Zilamac 500 mg/500 mg InjectionMacleods Pharmaceuticals Pvt Ltd ₹502.35 65.1% CHEAPER
-
imici 500mg/500mg injectionServo Healthcare ₹556.88 61.3% CHEAPER
-
cilareach 500mg/500mg injectionFusion Healthcare Pvt Ltd ₹599.00 58.4% CHEAPER
-
micromax injectionMicro Labs Ltd ₹612.19 57.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is only available as an intravenous injection and must be given by a healthcare professional. - Myth: This medicine is safe for everyone.
Fact: It is not safe for individuals with known allergies to carbapenems or severe kidney problems without dose adjustment. - Myth: This medicine can cure viral infections.
Fact: This medicine is an antibiotic and is ineffective against viruses like the common cold or flu.
🔄 Alternative Options
Generic Alternatives
- Imipenem and Cilastatin Injection
Brand Alternatives
- Avim C 500mg/500mg Injection