cefbactum  e.s 3gm 2000mg/1000mg injection - Cefoperazone (2000mg) + Sulbactam (1000mg) medicine

Bactofull Forte 2000mg/1000mg Injection: Complete Medicine Guide

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🏭 Medi Biotech Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 18, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for approved indications based on clinical experience and studies.
Reviewed by
SaathiMed Expert Panel | Oct 18, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or swelling of face, lips, or throat
  • Severe, watery, or bloody diarrhea
  • Rash with blistering or peeling skin
  • Unusual bleeding or bruising
  • Yellowing of eyes or skin
  • Decreased urine output or swelling in legs
  • High fever with chills and confusion

If experiencing severe symptoms, call emergency services immediately.

What is cefbactum e.s 3gm 2000mg/1000mg injection used for?

This medicine is a combination antibiotic given intravenously to treat serious bacterial infections. It contains cefoperazone, a cephalosporin, and sulbactam, which helps overcome bacterial resistance. It is used in hospitals for pneumonia, urinary tract infections, and other severe infections.

  • Generic Name: Cefoperazone + Sulbactam
  • Manufacturer: Medi Biotech Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 cefbactum e.s 3gm 2000mg/1000mg injection के बारे में (Hindi Summary)

उपयोग: यह दवा एक संयोजन एंटीबायोटिक है जिसका उपयोग गंभीर जीवाणु संक्रमणों के इलाज के लिए किया जाता है। इसमें सेफोपेराज़ोन और सल्बैक्टम शामिल हैं। यह निमोनिया, मूत्र पथ के संक्रमण, पेट के अंदर के संक्रमण, त्वचा के संक्रमण और रक्त के संक्रमण के इलाज में प्रभावी है। यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा नस के माध्यम से दी जाती है। इसे स्वयं न लें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, त्वचा पर चकत्ते और इंजेक्शन वाली जगह पर दर्द शामिल हैं। कुछ रोगियों को सिरदर्द या चक्कर आ सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें तेज बुखार, सांस लेने में कठिनाई, चेहरे या गले में सूजन, गंभीर दस्त, या खून की कमी शामिल हो सकती है। अगर ऐसा कुछ हो तो तुरंत डॉक्टर को बताएं।

सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर की देखरेख में ही दी जानी चाहिए। इसे स्वयं न लगाएं। अपने डॉक्टर को अपनी सभी एलर्जी, खासकर पेनिसिलिन या सेफलोस्पोरिन से एलर्जी के बारे में बताएं। अगर आपको किडनी या लीवर की बीमारी है तो डॉक्टर को जरूर बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। इलाज के दौरान शराब न पिएं। बेहतर महसूस होने पर भी दवा का कोर्स पूरा करें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 cefbactum e.s 3gm 2000mg/1000mg injection Uses & Benefits

[{"condition":"Community-acquired pneumonia","description":"Used for moderate to severe bacterial pneumonia caused by susceptible organisms, including Streptococcus pneumoniae, Haemophilus influenzae, and Klebsiella species.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Effective against pyelonephritis and complicated UTIs caused by susceptible Gram-negative bacteria, including Pseudomonas aeruginosa.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used for peritonitis, abscesses, and other intra-abdominal infections often involving mixed aerobic and anaerobic bacteria.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats cellulitis, abscesses, and wound infections caused by susceptible Gram-positive and Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Bloodstream infections (septicemia)","description":"Used for bacteremia caused by susceptible organisms, especially in hospitalized or immunocompromised patients.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Effective in pelvic inflammatory disease and endometritis caused by susceptible anaerobes and aerobes.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Febrile neutropenia","description":"Sometimes used as empirical therapy in cancer patients with fever and low white blood cell counts, though other agents are more commonly preferred.","evidence":"Limited"},{"condition":"Meningitis","description":"May be used off-label for bacterial meningitis when other options are not suitable, but penetration into cerebrospinal fluid is variable.","evidence":"Limited"}]

Primary treatment for: Bacterial infections

Also treats: Pneumonia, Urinary tract infections, Intra-abdominal infections, Skin infections, Septicemia

📋 Drug Information

Generic Name(s)Cefoperazone + Sulbactam
Brand NameAcuzone S 1000mg/500mg Injection
ManufacturerMedi Biotech Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassCephalosporin + Beta-lactamase inhibitor
Route of AdministrationIntravenous (IV) infusion or injection. It must be administered by a trained healthcare professional
StorageStore the unreconstituted powder at room temperature (15-30°C) in a dry place, protected from light. After reconstitution, the solution should be used immediately or stored as directed by the manufacturer. Do not freeze.
Shelf LifeTypically 24 months from the date of manufacture for the unreconstituted powder. Refer to the product packaging for the exact expiry date.
WHO GuidelineNot established from the available information. Guidelines may vary by region and infection type.
ICMR GuidelineNot established from the available information. Always follow local antimicrobial stewardship guidelines.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always reconstitute and administer this medicine under strict aseptic conditions to prevent contamination.
2
Assess renal function before and during therapy, as dose adjustment is often needed in kidney impairment.
3
Monitor for signs of superinfection, especially with prolonged use.
4
Avoid concomitant use with aminoglycosides unless necessary, and monitor renal function closely if combined.
5
Instruct patients to avoid alcohol during treatment and for at least 72 hours after the last dose.
6
Watch for bleeding tendencies, especially in patients on anticoagulants; monitor INR.
7
Educate patients about the importance of completing the full course even if symptoms improve.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Fever with chills
This medicine is commonly prescribed for bacterial infections causing fever.
Likely Use
✅
Burning urination
May be used for complicated urinary tract infections.
Likely Use
✅
Cough with yellow sputum
Used for bacterial pneumonia.
Likely Use
❌
Runny nose
This medicine is not effective for viral infections like the common cold.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is administered intravenously, so absorption is not applicable. It achieves high plasma concentrations directly after infusion.
DistributionCefoperazone distributes widely into body tissues and fluids, including bile, urine, peritoneal fluid, and respiratory secretions. It has moderate protein binding. Sulbactam also distributes into various tissues and body fluids.
Protein BindingCefoperazone is approximately 90% bound to plasma proteins. Sulbactam is about 38% bound to plasma proteins.
MetabolismCefoperazone is primarily excreted unchanged in bile and urine, with minimal metabolism. Sulbactam is largely excreted unchanged in urine, with a small fraction metabolized.
Half-LifeThe elimination half-life of cefoperazone is approximately 1.5 to 2.5 hours in healthy adults. Sulbactam has a half-life of about 1 hour. These may be prolonged in patients with renal or hepatic impairment.
ExcretionCefoperazone is excreted mainly in bile (about 70-80%) and to a lesser extent in urine (about 20-30%). Sulbactam is excreted primarily unchanged in urine (about 70-80%).
BioavailabilityNot applicable for intravenous administration; bioavailability is 100% by definition.
Onset of ActionThe onset of antibacterial action is rapid, typically within 30 minutes to 1 hour after intravenous infusion, as plasma concentrations exceed the MIC for susceptible organisms.
Peak Plasma TimePeak plasma concentrations are achieved at the end of the intravenous infusion, typically within 30 minutes to 1 hour.
Duration of ActionThe duration of action depends on the dosing interval, usually every 12 hours. Antibacterial effects persist as long as concentrations remain above the MIC for the pathogen.

How It Works

This medicine combines cefoperazone, a third-generation cephalosporin antibiotic, with sulbactam, a beta-lactamase inhibitor. Cefoperazone works by binding to penicillin-binding proteins (PBPs) on the bacterial cell wall, inhibiting the final step of peptidoglycan synthesis. This leads to weakening of the cell wall and bacterial lysis. Sulbactam irreversibly inhibits certain beta-lactamase enzymes produced by bacteria, protecting cefoperazone from degradation and extending its spectrum of activity against beta-lactamase-producing organisms.

Mechanism Steps

1
Cefoperazone binds to PBPs: Cefoperazone attaches to specific penicillin-binding proteins on the bacterial cell membrane, blocking the cross-linking of peptidoglycan chains.
2
Inhibition of cell wall synthesis: This prevents the formation of a stable bacterial cell wall, leading to osmotic instability.
3
Sulbactam inhibits beta-lactamases: Sulbactam binds irreversibly to beta-lactamase enzymes, preventing them from hydrolyzing cefoperazone.
4
Bacterial lysis and death: Without a functional cell wall, the bacterium takes up water and bursts, resulting in cell death.

💡 How to Take cefbactum e.s 3gm 2000mg/1000mg injection

Strength: This medicine is available as a sterile powder for injection containing 2000 mg cefoperazone and 1000 mg sulbactam per vial.

1This medicine is given by a healthcare professional as an intravenous infusion or injection.
2The powder is reconstituted with a suitable diluent as directed by the manufacturer.
3The solution is then administered slowly over 30 minutes to 2 hours, depending on the dose and clinical setting.
4Do not self-administer; always seek professional medical assistance.
5Follow your doctor's instructions regarding the duration of treatment.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 1 to 2 grams of cefoperazone combined with 0.5 to 1 gram of sulbactam, administered intravenously every 12 hours. For severe infections, the dose may be increased to 4 grams of cefoperazone with 2 grams of sulbactam per day, divided into two doses. The exact dose and duration must be individualized by a qualified clinician based on the type and severity of infection, age, weight, renal and hepatic function, and clinical response.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children.
Elderly DosageElderly patients may have reduced renal function, which can affect the elimination of this medicine. Dose adjustment may be necessary based on kidney function. Your doctor will determine the appropriate dose.
Renal ImpairmentIn patients with renal impairment, the dose of this medicine may need to be reduced. For creatinine clearance less than 30 mL/min, the dose should be adjusted. It is recommended to monitor renal function closely and individualize the dose. In severe renal impairment, the dose may be reduced or the interval extended.
Hepatic ImpairmentIn patients with hepatic impairment, cefoperazone elimination may be prolonged. Dose adjustment may be required. Monitor liver function tests. In combined hepatic and renal impairment, dose reduction is often necessary.
Maximum Daily DoseThe maximum recommended daily dose is 4 grams of cefoperazone and 2 grams of sulbactam, but this may vary based on the severity of infection and renal function. Always follow your doctor's prescription.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

Alcohol
Avoid
May cause disulfiram-like reaction.
Food in general
No restrictions
This medicine is given intravenously; food does not affect its absorption.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of cefbactum e.s 3gm 2000mg/1000mg injection

✅ Common Side Effects

Diarrhea (Common (5-10%))
Stay hydrated. If diarrhea is severe or persistent, contact your doctor.
Nausea (Common (3-5%))
Usually resolves. Inform your doctor if it interferes with eating.
Rash (Common (2-5%))
Report to your doctor. If rash spreads or is accompanied by fever, seek immediate care.
Injection site pain (Common (5-10%))
Apply a warm compress if advised. Report severe pain or swelling.
Vomiting (Uncommon (1-3%))
Inform your doctor if persistent.

🚨 Serious Side Effects

Anaphylaxis (Rare (<0.1%))
Seek emergency medical help immediately if you experience difficulty breathing, swelling of face or throat, or a sudden drop in blood pressure.
Clostridioides difficile-associated diarrhea (Rare (0.1-1%))
Contact your doctor if you develop severe, watery, or bloody diarrhea, even weeks after treatment.
Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) (Very rare (<0.01%))
Seek immediate medical attention if you notice a painful rash, blistering, or peeling skin.
Blood dyscrasias (e.g., neutropenia, thrombocytopenia) (Rare (<0.1%))
Report unusual bruising, bleeding, or signs of infection. Your doctor may monitor blood counts.
Hepatotoxicity (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or right upper abdominal pain.
Nephrotoxicity (Rare (<0.1%))
Report decreased urine output or swelling. Kidney function may be monitored.

⚠️ Rare Side Effects

Seizures
Seek emergency care if seizures occur, especially in patients with renal impairment.
Pseudomembranous colitis
Seek medical attention for severe diarrhea with abdominal pain or fever.
Interstitial nephritis
Report fever, rash, and decreased urine output.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Aminoglycosides Major
Warfarin Major
Alcohol Major
Loop diuretics Moderate
Probenecid Moderate
Oral contraceptives Minor

🚨 Major Interactions

  • Aminoglycosides (e.g., gentamicin, amikacin)
  • Warfarin
  • Alcohol

⚡ Moderate Interactions

  • Loop diuretics (e.g., furosemide)
  • Probenecid

🍷 Alcohol Interaction

Avoid alcohol while receiving this medicine and for at least 72 hours after the last dose. Alcohol can trigger a disulfiram-like reaction characterized by flushing, severe nausea, vomiting, sweating, and headache. It may also increase the risk of liver toxicity.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known severe allergy to cefoperazone, sulbactam, or other beta-lactam antibiotics (penicillins, cephalosporins)","Previous anaphylactic reaction to any beta-lactam antibiotic","Use in patients with a history of severe immediate hypersensitivity to penicillins"]

⚠️ Warnings & Precautions

["Before starting this medicine, inform your doctor about all your allergies, especially to antibiotics.","Use with caution in patients with kidney or liver impairment; dose adjustment may be needed.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","May cause false-positive results in certain urine glucose tests.","Avoid alcohol during treatment and for at least 72 hours after the last dose.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","This medicine may interact with other drugs; provide a complete list of medications to your doctor."]

🤱 Lactation Safety

Cefoperazone and sulbactam are excreted in human milk in small amounts. Consult your doctor before breastfeeding while on this medicine. The benefits of breastfeeding should be weighed against the potential risks to the infant.

💊 Overdose Management

Overdose with this medicine is unlikely due to its intravenous administration by healthcare professionals. In case of accidental overdose, treatment should be symptomatic and supportive. Cefoperazone and sulbactam can be removed by hemodialysis in patients with renal failure. Monitor vital signs and provide supportive care as needed.

⏰ Missed Dose

Since this medicine is administered by a healthcare professional, missed doses are unlikely. If a dose is missed, it should be given as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.

Additional Safety Advice

General Safety

This medicine must be given only by a healthcare professional in a hospital or clinic setting. Do not attempt to self-administer. Inform your doctor about all your allergies, especially to penicillins or cephalosporins, and any history of kidney or liver disease. Your doctor may adjust the dose based on your kidney function. Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Avoid alcohol while receiving this medicine as it may increase the risk of side effects. Do not stop the treatment early even if you feel better, as this can lead to relapse or resistance. Report any new symptoms such as severe diarrhea, rash, or difficulty breathing immediately.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more likely to have reduced kidney function, which can affect the elimination of this medicine. Dose adjustment may be necessary. Monitor renal function closely and watch for signs of toxicity.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, discuss with your doctor before starting this medicine. It should be used during pregnancy only if clearly needed. Effective contraception is recommended during treatment.

🏥 Post-Surgery Considerations

This medicine is often used to prevent or treat surgical site infections. It may be given before, during, or after surgery. Follow your surgeon's instructions regarding its use.

🦷 Dental Procedures

Inform your dentist if you are receiving this medicine. It may be used prophylactically before dental procedures in patients at risk of infective endocarditis, but this is determined by your doctor.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help flush out bacteria and support kidney function.
🥗
Eat a balanced diet rich in fruits and vegetables to support your immune system.
😴
Get plenty of rest to aid recovery from infection.
💧
Avoid alcohol during treatment and for at least 72 hours after.
🧘
Practice good hygiene to prevent reinfection.
🌞
Complete the full course of antibiotics as prescribed.

🏋️ Exercise Considerations

While on this medicine, you may feel tired or dizzy. Avoid strenuous exercise until you feel fully recovered. Light activity like walking is fine if you feel up to it. Consult your doctor before resuming intense workouts.

🥗 Diet Recommendations

Include probiotic-rich foods like yogurt to help maintain gut health.
Stay hydrated with water and clear fluids.
Avoid alcohol completely during treatment.
Eat small, frequent meals if you have nausea.
Include foods rich in vitamin C to support immunity.

💼 Impact on Daily Work & Life

This medicine is given in a hospital setting, so you may need to take time off work during treatment. You may experience fatigue or dizziness; avoid driving or operating heavy machinery until you know how the medicine affects you. Discuss with your employer about sick leave.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. Stopping early can lead to relapse or antibiotic resistance. Your doctor will determine when to stop based on your clinical response and culture results. If you experience severe side effects, contact your doctor immediately.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to bacterial resistance, superinfections, and rarely, blood disorders or liver/kidney problems. Prolonged therapy should be guided by clinical response and culture results. Regular monitoring of blood counts, liver and kidney function is advised during extended treatment.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Other antibiotics

Depending on the causative organism and susceptibility, other antibiotics like ceftriaxone, piperacillin-tazobactam, or carbapenems may be used.

Evidence: Well-established
Supportive care

Hydration, fever control, and rest are important adjuncts to antibiotic therapy.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are due for a vaccine, inform your doctor. Live vaccines should be avoided during acute infection.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

This medicine is administered in a healthcare setting, so travel is not typically applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as directed, and keep it in its original packaging. For international travel, check customs regulations regarding injectable antibiotics. Always inform your healthcare provider if you are planning to travel during treatment.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 58-year-old man with diabetes admitted for severe urinary tract infection.
He was started on this medicine intravenously. His fever subsided within 48 hours, and his urine culture showed susceptibility to the combination. He completed a 7-day course and recovered fully. He was advised to avoid alcohol and to monitor his kidney function.
💡 Lesson: This medicine is effective for complicated UTIs when the organism is susceptible. Adherence to the full course and monitoring of renal function are crucial.
👤 A 35-year-old woman developed a severe skin infection after a minor surgery.
She was treated with this medicine intravenously. The infection resolved within 5 days. She experienced mild diarrhea, which was managed with hydration. She was advised to complete the course and report any new symptoms.
💡 Lesson: This medicine is effective for skin and soft tissue infections. Mild side effects like diarrhea are common but manageable. Completing the course prevents recurrence.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start feeling better within 48 to 72 hours after starting treatment, but it is important to complete the full course as prescribed.

Q: Can I take this medicine at home?

A: No, this medicine must be given intravenously by a healthcare professional in a hospital or clinic setting.

Q: What should I do if I experience side effects?

A: Report any side effects to your doctor immediately. Mild side effects like nausea or diarrhea may resolve, but severe reactions require urgent medical attention.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine if I am allergic to penicillin?
  • Will this medicine affect my kidney function?
  • Can I breastfeed while on this medicine?
  • How long will I need to stay in the hospital?
  • What if I miss a dose?
  • Can I drink alcohol while on this medicine?

🔄 Substitutes for cefbactum e.s 3gm 2000mg/1000mg injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure any infection.
    Fact: This medicine is effective only against susceptible bacteria. It does not treat viral infections like colds or flu.
  • Myth: You can stop the medicine once you feel better.
    Fact: You must complete the full course as prescribed to prevent relapse and resistance.
  • Myth: This medicine is safe to take without a doctor's supervision.
    Fact: This is a prescription medicine that must be given by a healthcare professional in a monitored setting.

🔄 Alternative Options

Generic Alternatives

  • Cefoperazone + Sulbactam injection (generic versions available)

Brand Alternatives

  • Bactofull Forte 2000mg/1000mg Injection

📊 Comparison with Similar Medicines

[{"medicine":"Cefoperazone + Sulbactam","class":"Third-generation cephalosporin + beta-lactamase inhibitor","route":"Intravenous","spectrum":"Broad, including Pseudomonas","common_use":"Hospital-acquired infections"},{"medicine":"Ceftriaxone + Sulbactam","class":"Third-generation cephalosporin + beta-lactamase inhibitor","route":"Intravenous","spectrum":"Broad, but less Pseudomonas coverage","common_use":"Community-acquired infections"},{"medicine":"Piperacillin + Tazobactam","class":"Ureidopenicillin + beta-lactamase inhibitor","route":"Intravenous","spectrum":"Broad, including Pseudomonas","common_use":"Hospital-acquired infections"}]

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