Azmarda 100mg Tablet: A Comprehensive Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat
- Difficulty breathing or swallowing
- Severe dizziness or fainting
- Decreased urine output or swelling in the legs
- Irregular heartbeat or muscle weakness
- Yellowing of the skin or eyes
- Severe abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is cidmus 100mg tablet used for?
This medicine is a combination of sacubitril and valsartan used to treat heart failure with reduced ejection fraction. It works by relaxing blood vessels and reducing strain on the heart, improving survival and reducing hospitalizations.
- Generic Name: Sacubitril + Valsartan
- Manufacturer: Dr Reddy's Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cidmus 100mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सैकुबिट्रिल और वाल्सार्टन का संयोजन है, जिसका उपयोग हृदय विफलता (हार्ट फेल्योर) के इलाज के लिए किया जाता है। यह दिल की मांसपेशियों को आराम देकर और रक्त वाहिकाओं को फैलाकर दिल पर दबाव कम करती है। यह दवा उन रोगियों के लिए है जिनका दिल ठीक से खून नहीं पंप कर पाता। यह दवा दिल की विफलता के लक्षणों को कम करती है और अस्पताल में भर्ती होने के जोखिम को कम करती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, कम रक्तचाप, खांसी, और गुर्दे की समस्याएं शामिल हैं। गंभीर दुष्प्रभावों में एंजियोएडेमा (चेहरे, होंठ, जीभ या गले में सूजन) शामिल है, जिसके लिए तत्काल चिकित्सा की आवश्यकता होती है। यदि आपको कोई गंभीर दुष्प्रभाव महसूस होता है, तो तुरंत अपने डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को बताएं यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं। यह दवा गर्भावस्था के दौरान हानिकारक हो सकती है। यदि आपको एसीई इनहिबिटर या एआरबी से संबंधित एंजियोएडेमा का इतिहास है, तो यह दवा न लें। अपने डॉक्टर की सलाह के बिना पोटेशियम सप्लीमेंट या नमक के विकल्प न लें। अपने डॉक्टर द्वारा नियमित रूप से रक्तचाप, गुर्दे की कार्यप्रणाली और पोटेशियम के स्तर की निगरानी करवाएं। इस दवा को अचानक बंद न करें।
💊 cidmus 100mg tablet Uses & Benefits
- [{"condition":"Heart failure with reduced ejection fraction (HFrEF)","description":"This medicine is used to reduce the risk of cardiovascular death and hospitalization for heart failure in adults with chronic heart failure and reduced ejection fraction.
- It is typically used in place of an ACE inhibitor or ARB in patients who remain symptomatic despite optimal therapy.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Heart failure with preserved ejection fraction (HFpEF)","description":"Some studies suggest potential benefit in HFpEF, but this is not an approved indication and more research is needed.","evidence":"Limited"},{"condition":"Hypertension","description":"This medicine may be used off-label for treating high blood pressure, but it is not a first-line treatment.","evidence":"Limited"}]
Primary treatment for: Heart failure with reduced ejection fraction (HFrEF)
Also treats: Hypertension, Chronic kidney disease, Diabetes
📋 Drug Information
| Generic Name(s) | Sacubitril + Valsartan |
| Brand Name | Azmarda 50mg Tablet |
| Manufacturer | Dr Reddy's Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Angiotensin Receptor Neprilysin Inhibitor (ARNI) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F and 86°F). Keep in the original container to protect from moisture. Do not refrigerate. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization does not provide specific guidelines for this medicine. However, major cardiology societies recommend ARNIs as a first-line treatment for HFrEF. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) does not have specific guidelines for this medicine. However, it is recommended in Indian heart failure guidelines based on international evidence. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients: sacubitril and valsartan. Sacubitril is a neprilysin inhibitor. Neprilysin is an enzyme that breaks down natriuretic peptides, which are substances that help relax blood vessels, increase urine output, and reduce strain on the heart. By inhibiting neprilysin, sacubitril increases the levels of these beneficial peptides. Valsartan is an angiotensin II receptor blocker (ARB). It works by blocking the action of angiotensin II, a hormone that constricts blood vessels and increases blood pressure. By blocking angiotensin II, valsartan helps blood vessels relax and lowers blood pressure. Together, these two actions reduce the workload on the heart, lower blood pressure, and improve heart function in patients with heart failure.
Mechanism Steps
💡 How to Take cidmus 100mg tablet
Strength: 100 mg tablet containing 49 mg sacubitril and 51 mg valsartan.
Dosage Information
| Adult Dosage | The usual starting dose of this medicine is 49 mg sacubitril/51 mg valsartan (one 100 mg tablet) taken orally twice daily. The dose may be increased after 2-4 weeks to 97 mg sacubitril/103 mg valsartan (one 200 mg tablet) twice daily, as tolerated. For patients not currently taking an ACE inhibitor or ARB, or with severe kidney or liver impairment, a lower starting dose of 24 mg sacubitril/26 mg valsartan twice daily may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and blood pressure. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No dose adjustment is required based on age alone. However, elderly patients may be more sensitive to the blood pressure-lowering effects. Monitor blood pressure and kidney function closely. |
| Renal Impairment | For patients with mild to moderate renal impairment (eGFR 30-60 mL/min/1.73 m²), no dose adjustment is needed. For severe renal impairment (eGFR <30 mL/min/1.73 m²), a lower starting dose of 24 mg sacubitril/26 mg valsartan twice daily is recommended. Use with caution and monitor kidney function. |
| Hepatic Impairment | For patients with mild hepatic impairment (Child-Pugh A), no dose adjustment is needed. For moderate hepatic impairment (Child-Pugh B), a lower starting dose of 24 mg sacubitril/26 mg valsartan twice daily is recommended. This medicine is contraindicated in severe hepatic impairment (Child-Pugh C). |
| Maximum Daily Dose | The maximum recommended dose is 97 mg sacubitril/103 mg valsartan twice daily (200 mg total per dose). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cidmus 100mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| ACE inhibitors | Major | |
| Potassium-sparing diuretics | Major | |
| NSAIDs | Major | |
| Lithium | Major | |
| Diuretics | Moderate | |
| Beta-blockers | Moderate | |
| Calcium channel blockers | Moderate | |
| Metformin | Minor | |
| Statins | Minor | |
| Warfarin | Moderate |
🚨 Major Interactions
- ACE inhibitors (e.g., lisinopril, enalapril)
- Potassium-sparing diuretics (e.g., spironolactone)
- NSAIDs (e.g., ibuprofen, naproxen)
- Lithium
⚡ Moderate Interactions
- Diuretics (e.g., furosemide)
- Beta-blockers
- Calcium channel blockers
🍷 Alcohol Interaction
Alcohol may increase the blood pressure-lowering effect of this medicine, leading to dizziness and fainting. It is advisable to limit or avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy","History of angioedema related to ACE inhibitors or ARBs","Severe liver impairment","Concomitant use with ACE inhibitors","Known hypersensitivity to sacubitril, valsartan, or any component of the formulation"]
⚠️ Warnings & Precautions
["This medicine can cause angioedema. Discontinue immediately if angioedema occurs and seek emergency care.","This medicine can cause low blood pressure. Monitor blood pressure regularly, especially when starting or increasing the dose.","This medicine can increase potassium levels. Avoid potassium supplements and salt substitutes containing potassium.","This medicine can cause kidney problems. Regular monitoring of kidney function is required.","This medicine is contraindicated during pregnancy. Use effective contraception.","Do not use this medicine with ACE inhibitors. Allow a 36-hour washout period when switching.","This medicine may cause dizziness. Avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you have a history of liver or kidney disease.","Do not stop taking this medicine suddenly without consulting your doctor."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the medicine, taking into account the importance of the medicine to the mother.
💊 Overdose Management
Overdose of this medicine may cause severe low blood pressure, dizziness, and fainting. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Hemodialysis may not effectively remove the medicine from the body.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Before taking this medicine, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. This medicine can harm an unborn baby, so it is not recommended during pregnancy. Do not take this medicine if you have a history of angioedema related to ACE inhibitors or ARBs, or if you have severe liver problems. Avoid taking potassium supplements or salt substitutes containing potassium without your doctor's approval, as this medicine can increase potassium levels. Your doctor will monitor your blood pressure, kidney function, and potassium levels regularly. Do not stop taking this medicine suddenly without consulting your doctor, as this can worsen your heart failure. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Store this medicine at room temperature away from moisture and heat. Keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Monitor blood pressure and kidney function closely. No dose adjustment is required based on age alone, but individualization is important.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy. Women of childbearing potential should use effective contraception while taking this medicine. If you are planning to become pregnant, consult your doctor to discuss alternative treatments.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be temporarily stopped before surgery due to its blood pressure-lowering effects. Follow your doctor's instructions.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may cause dizziness or low blood pressure during the procedure. Your dentist may take precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally encouraged, but avoid strenuous activities that cause shortness of breath or dizziness. Consult your doctor before starting any new exercise program. If you experience chest pain, severe shortness of breath, or fainting during exercise, stop immediately and seek medical attention.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or low blood pressure, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Most people can continue their normal daily activities with appropriate monitoring and dose adjustments.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as angioedema, severe hypotension, or kidney problems, contact your doctor immediately. Your doctor may adjust the dose or switch to another medicine.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe and beneficial for heart failure patients. It reduces the risk of cardiovascular death and hospitalization. Regular monitoring of kidney function, potassium levels, and blood pressure is required. Some patients may experience persistent cough or dizziness. Do not stop the medicine without consulting your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Alternative class of medicines for heart failure, but may cause cough.
Evidence: Well-establishedAlternative class for patients who cannot tolerate ACE inhibitors.
Evidence: Well-establishedOften used in combination with other heart failure medicines.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, patients with heart failure should stay up to date with influenza and pneumococcal vaccinations as recommended by their doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and avoid exposure to heat or moisture. If crossing time zones, adjust dosing times gradually in consultation with your doctor. Check local customs regulations for carrying prescription medicines. Always carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts to lower blood pressure within 2 weeks, but its full benefits for heart failure may take several weeks to months. Continue taking it as prescribed.
A: Yes, you can take this medicine with or without food. However, take it consistently at the same times each day.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: No, this medicine is contraindicated during pregnancy as it can harm the unborn baby. Use effective contraception and inform your doctor if you become pregnant.
A: No, do not stop taking this medicine suddenly without consulting your doctor, as this can worsen your heart failure.
🤔 Common Patient Concerns
🔄 Substitutes for cidmus 100mg tablet
View AllAlternative brands with exact same active ingredient:
-
zayo 100 tabletEris Lifesciences Ltd ₹396.66 55.2% CHEAPER
-
neptaz 100mg tabletMankind Pharma Ltd ₹554.24 37.4% CHEAPER
-
azmarda 100mg tabletJ B Chemicals and Pharmaceuticals Ltd ₹938.54 6% COSTLIER
-
vymada 100mg tabletNovartis India Ltd ₹944.50 6.6% COSTLIER
-
sacutan 100 tabletMSN Laboratories ₹1,406.25 58.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure heart failure.
Fact: This medicine helps manage heart failure symptoms and improves survival but does not cure the condition. - Myth: This medicine can be taken during pregnancy.
Fact: This medicine is contraindicated during pregnancy as it can harm the unborn baby. - Myth: This medicine can be taken with ACE inhibitors.
Fact: This medicine should not be taken with ACE inhibitors due to increased risk of angioedema.
🔄 Alternative Options
Generic Alternatives
- Sacubitril and Valsartan combination generics may be available.
Brand Alternatives
- Azmarda 100mg Tablet
- Entresto 100mg Tablet
- Vymada 100mg Tablet