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chronol 250mg tablet

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Disulfiram (250mg)

🏭 Kolson India Healthcare Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Jul 5, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Jul 05, 2026

What is chronol 250mg tablet used for?

Alcoban (Disulfiram) is used to treat NEURO CNS. It contains Disulfiram (250mg), which Irreversibly inhibits aldehyde dehydrogenase, causing accumulation of acetaldehy. Always consult your doctor before use. Take as prescribed.

Generic Name: Disulfiram
Manufacturer: Kolson India Healthcare Pvt Ltd
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 chronol 250mg tablet Uses & Benefits

Management of chronic alcohol dependence as an adjunct to psychosocial therapy.

Off-label uses: Treatment of cocaine dependence (limited evidence).

📋 Drug Information

Generic Name(s)	Disulfiram
Brand Name	Alcoban
Manufacturer	Kolson India Healthcare Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	NEURO CNS
Action Class	Alcohol deaddiction
Route of Administration	Oral
Storage	Store at room temperature (20-25°C) in a dry place, away from light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed from the gastrointestinal tract.

DistributionWidely distributed throughout the body; crosses the blood-brain barrier.

Protein Binding96% bound to plasma proteins.

MetabolismMetabolized in the liver to diethyldithiocarbamate, which is further metabolized.

Half-Life7-10 hours; however, the duration of action is longer due to irreversible inhibition of aldehyde deh

ExcretionPrimarily excreted in urine as metabolites; small amount in feces.

BioavailabilityApproximately 80-90% after oral administration.

Onset of Action1-2 hours after ingestion.

Peak Plasma Time3-4 hours.

Duration of ActionUp to 14 days after last dose due to irreversible enzyme inhibition.

How It Works

Irreversibly inhibits aldehyde dehydrogenase, causing accumulation of acetaldehyde when alcohol is consumed, leading to unpleasant effects.

Mechanism Steps

1Disulfiram is absorbed and distributed to the liver.

2It irreversibly inhibits aldehyde dehydrogenase (ALDH) by binding to its active site.

3When alcohol is consumed, ethanol is metabolized to acetaldehyde by alcohol dehydrogenase.

💡 How to Take chronol 250mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of chronol 250mg tablet

✅ Common Side Effects

Drowsiness
Fatigue
Metallic taste
Headache
Impotence
Acneiform rash

🚨 Serious Side Effects

Hepatotoxicity
Peripheral neuropathy
Psychotic reactions
Optic neuritis

⚠️ Rare Side Effects

Allergic dermatitis
Thrombocytopenia
Cholestatic hepatitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Alcohol	Major	Severe disulfiram-ethanol reaction (flushing, nausea, vomiting, hypotension, confusion, arrhythmias).
Metronidazole	Major	Increased risk of disulfiram-like reaction.
Warfarin	Major	Increased anticoagulant effect and bleeding risk.
Isoniazid	Major	Increased risk of hepatotoxicity and CNS effects.
Phenytoin	Major	Increased phenytoin levels and toxicity.

🚨 Major Interactions

Alcohol
Metronidazole
Paraldehyde
Warfarin
Isoniazid
Phenytoin
Benzodiazepines

⚡ Moderate Interactions

Anticoagulants
Theophylline
Cimetidine
Omeprazole
Oral hypoglycemics

ℹ️ Minor Interactions

Acetaminophen
Caffeine
Antacids

🍽️ Food Interactions

Avoid foods containing alcohol (e.g., sauces, vinegars, some desserts).

🍷 Alcohol Interaction

Severe disulfiram-ethanol reaction (DER) can occur up to 14 days after last dose.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, severe myocardial disease, psychosis, alcohol intoxication, recent alcohol consumption (within 12 hours), severe liver disease.

📊 Monitoring Parameters

Liver function tests (LFTs) at baseline and periodically; monitor for signs of DER; blood alcohol levels if needed.

🤱 Lactation Safety

Not recommended; excreted in breast milk.

💊 Overdose Management

Supportive care; monitor vital signs; treat symptoms; no specific antidote.

⏰ Missed Dose

Take as soon as remembered unless close to next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Jul 05, 2026

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🔄 Substitutes for chronol 250mg tablet

View All

Alternative brands with exact same active ingredient (Disulfiram (250mg)):

Medical Note: Always consult your doctor before switching medications.

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📌 Quick Facts

Storage	Store at room temperature (20-25°C) in a dry place, away from light.
Route	Oral
Pregnancy	Category C
Breastfeeding	Not recommended; excreted in breast milk.
Alcohol	Severe disulfiram-ethanol reaction (DER) can occur up to 14 days after last dose.
Onset of Action	1-2 hours after ingestion.
Half-Life	7-10 hours; however, the duration of action is longer due to irreversible inhibition of aldehyde deh
Prescription	✅ Required

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