chlorectil plus 200mg/2mg tablet - Uses, Price, Side Effects & Substitutes
What is chlorectil plus 200mg/2mg tablet used for?
Clozine Forte (Chlorpromazine + Trihexyphenidyl) is used to treat NEURO CNS. It contains Chlorpromazine (200mg) + Trihexyphenidyl (2mg), which Chlorpromazine blocks dopamine D2 receptors in the brain; trihexyphenidyl blocks. Always consult your doctor before use. Take as prescribed.
- Generic Name: Chlorpromazine + Trihexyphenidyl
- Manufacturer: Saga Laboratories
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ chlorectil plus 200mg/2mg tablet Uses & Benefits
๐ Drug Information
| Generic Name(s) | Chlorpromazine + Trihexyphenidyl |
| Brand Name | Clozine Forte |
| Manufacturer | Saga Laboratories |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Antipsychotic + Anticholinergic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Chlorpromazine blocks dopamine D2 receptors in the brain; trihexyphenidyl blocks muscarinic acetylcholine receptors to reduce extrapyramidal side effects
Mechanism Steps
๐ก How to Take chlorectil plus 200mg/2mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of chlorectil plus 200mg/2mg tablet
โ Common Side Effects
- Drowsiness
- dry mouth
- blurred vision
- constipation
- urinary retention
- weight gain
- orthostatic hypotension
๐จ Serious Side Effects
- Tardive dyskinesia
- neuroleptic malignant syndrome
- seizures
- QT prolongation
- agranulocytosis
- jaundice
โ ๏ธ Rare Side Effects
- Photosensitivity
- lupus-like syndrome
- galactorrhea
- gynecomastia
- impotence
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| CNS depressants | Major | Enhanced sedation and respiratory depression |
| Antihypertensives | Major | Additive hypotensive effect |
| Levodopa | Major | Antagonism of levodopa effect |
| Lithium | Major | Increased risk of neurotoxicity |
| MAO inhibitors | Major | Hypertensive crisis |
| Anticholinergics | Moderate | Additive anticholinergic effects |
| Antidiabetics | Moderate | Altered blood glucose control |
| Antiepileptics | Moderate | Lowered seizure threshold |
| Anticoagulants | Moderate | Increased anticoagulant effect |
| Beta-blockers | Moderate | Additive hypotension |
| Antacids | Minor | Decreased absorption of chlorpromazine |
| Cimetidine | Minor | Increased chlorpromazine levels |
| Smoking | Minor | Decreased chlorpromazine levels |
๐จ Major Interactions
- CNS depressants
- Antihypertensives
- Levodopa
- Lithium
- MAO inhibitors
โก Moderate Interactions
- Anticholinergics
- Antidiabetics
- Antiepileptics
- Anticoagulants
- Beta-blockers
โน๏ธ Minor Interactions
- Antacids
- Cimetidine
- Smoking
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase chlorpromazine levels; food may delay absorption
๐ท Alcohol Interaction
Increased CNS depression; avoid alcohol
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, coma, bone marrow depression, severe hepatic or renal impairment, narrow-angle glaucoma, prostatic hypertrophy
๐ Monitoring Parameters
Blood pressure, heart rate, ECG, liver function, renal function, blood counts, extrapyramidal symptoms, tardive dyskinesia
๐คฑ Lactation Safety
Not recommended; excreted in breast milk
๐ Overdose Management
Supportive care; activated charcoal, gastric lavage; treat hypotension with IV fluids and vasopressors; avoid epinephrine; monitor ECG
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip if close to next dose; do not double dose