chileye ophthalmic solution - Naphazoline (0.05% w/v) + Phenylephrine (0.12% w/v) medicine

chileye ophthalmic solution

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🏭 Eyekare Kilitch Limited 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 22, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 22, 2026

What is chileye ophthalmic solution used for?

This medicine contains Naphazoline (0.05% w/v) + Phenylephrine (0.12% w/v) and is used to treat OPHTHAL. Stimulates alpha-adrenergic receptors in the conjunctival blood vessels, causing vasoconstriction an. Always consult your doctor before use.

  • Generic Name: Naphazoline + Phenylephrine
  • Manufacturer: Eyekare Kilitch Limited
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 chileye ophthalmic solution Uses & Benefits

Relief of redness and congestion of the eye due to minor irritations

Off-label uses: Not commonly used off-label

📋 Drug Information

Generic Name(s)Naphazoline + Phenylephrine
Brand NameChileye Ophthalmic Solution
ManufacturerEyekare Kilitch Limited
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL
Action ClassSympathomimetic
Route of AdministrationOphthalmic (topical to the eye)
StorageStore at room temperature (20-25°C); protect from light
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMinimal systemic absorption following ocular administration
DistributionPrimarily local ocular distribution; minimal systemic distribution
Protein BindingNot well characterized; likely low
MetabolismMetabolized by monoamine oxidase (MAO) in the liver and locally in the eye
Half-LifeApproximately 2-3 hours for naphazoline; phenylephrine half-life about 2-3 hours
ExcretionRenal excretion of metabolites
BioavailabilityLow systemic bioavailability due to minimal absorption
Onset of ActionWithin minutes after instillation
Peak Plasma TimeNot applicable; minimal systemic absorption
Duration of Action4-6 hours

How It Works

Stimulates alpha-adrenergic receptors in the conjunctival blood vessels, causing vasoconstriction and reducing redness

Mechanism Steps

1Instillation into the conjunctival sac
2Diffusion to ocular tissues
3Binding to alpha-adrenergic receptors on conjunctival blood vessels
4Activation of G-protein coupled receptor signaling
5Vasoconstriction of conjunctival arterioles
6Reduction of ocular redness and congestion

💡 How to Take chileye ophthalmic solution

Follow your doctor's prescription exactly.

⚠️ Side Effects of chileye ophthalmic solution

✅ Common Side Effects

Transient stinging or burning
Blurred vision
Eye irritation
Dryness

🚨 Serious Side Effects

Increased intraocular pressure
Systemic hypertension
Arrhythmias
Allergic reactions

⚠️ Rare Side Effects

Rebound congestion
Mydriasis
Corneal edema

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAO inhibitors Major Hypertensive crisis
Tricyclic antidepressants Major Enhanced pressor response
Beta-blockers Moderate Increased risk of hypertension
Digoxin Moderate Increased risk of arrhythmias
Ergot alkaloids Moderate Enhanced vasoconstriction
Antihypertensives Minor Reduced antihypertensive effect
Sympathomimetics Minor Additive effects

🚨 Major Interactions

  • MAO inhibitors
  • Tricyclic antidepressants

⚡ Moderate Interactions

  • Beta-blockers
  • Digoxin
  • Ergot alkaloids

🍷 Alcohol Interaction

May increase risk of hypotension or dizziness

🛡️ Safety & Warnings

🚫 Contraindications

Narrow-angle glaucoma, hypersensitivity to any component, patients with cardiovascular disease or hypertension

🤱 Lactation Safety

Use with caution; not recommended unless clearly needed

💊 Overdose Management

Discontinue use; supportive care; monitor for systemic effects such as hypertension, bradycardia, and CNS depression

⏰ Missed Dose

If a dose is missed, use as soon as remembered; do not double the dose

🔄 Substitutes for chileye ophthalmic solution

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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