Augxetil CV 250 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe or persistent diarrhea, abdominal cramps, or fever
- Yellowing of the skin or eyes, dark urine, or right upper abdominal pain
- Painful rash with blisters, peeling skin, or sores in the mouth or eyes
- Seizures or confusion, especially in patients with kidney disease
- Unusual bleeding or bruising
- Decreased urine output or swelling in the legs
If experiencing severe symptoms, call emergency services immediately.
What is cfuro cv 250mg/125mg tablet used for?
This medicine is a combination antibiotic containing cefuroxime and clavulanic acid. It is used to treat bacterial infections of the respiratory tract, urinary tract, skin, and other areas. It works by killing bacteria and blocking their resistance mechanisms. Take it with food as prescribed by your doctor.
- Generic Name: Cefuroxime + Clavulanic Acid
- Manufacturer: Hetero Drugs Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cfuro cv 250mg/125mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सेफ्यूरोक्सिम और क्लैवुलैनिक एसिड का संयोजन है, जिसका उपयोग बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह श्वसन तंत्र, मूत्र मार्ग, त्वचा और कोमल ऊतकों के संक्रमणों में प्रभावी है। यह बैक्टीरिया की कोशिका भित्ति को नष्ट करके और बीटा-लैक्टामेज एंजाइम को रोककर काम करती है। इसे डॉक्टर के निर्देशानुसार भोजन के साथ लें और पूरा कोर्स पूरा करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, पेट दर्द, सिरदर्द और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, गंभीर त्वचा प्रतिक्रियाएं, यकृत की समस्या और दस्त के कारण निर्जलीकरण हो सकता है। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो और अवशोषण बेहतर हो। पूरा कोर्स पूरा करें, चाहे आप बेहतर महसूस करें। शराब न लें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। इसे बच्चों की पहुंच से दूर रखें। यदि खुराक छूट जाए तो याद आते ही लें, लेकिन अगली खुराक का समय नजदीक हो तो छोड़ दें। दोहरी खुराक न लें।
💊 cfuro cv 250mg/125mg tablet Uses & Benefits
[{"condition":"Respiratory tract infections","description":"Used to treat community-acquired pneumonia, acute bacterial exacerbations of chronic bronchitis, and acute bacterial sinusitis caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against uncomplicated and complicated urinary tract infections caused by susceptible bacteria such as Escherichia coli and Klebsiella species.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for treating cellulitis, abscesses, and wound infections caused by susceptible Gram-positive and Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"May be used for osteomyelitis and septic arthritis caused by susceptible organisms, often as part of a broader treatment plan.","evidence":"Moderate"},{"condition":"Gonorrhea","description":"Cefuroxime is effective against uncomplicated gonorrhea caused by Neisseria gonorrhoeae, though clavulanic acid adds little benefit.","evidence":"Well-established"},{"condition":"Lyme disease","description":"Cefuroxime is used for early Lyme disease and Lyme arthritis in patients who cannot take doxycycline.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Prophylaxis in dental procedures","description":"Sometimes used off-label for prevention of infective endocarditis in high-risk patients undergoing dental procedures, though guidelines vary.","evidence":"Limited"},{"condition":"Traveler's diarrhea","description":"May be used off-label for moderate to severe traveler's diarrhea caused by susceptible bacteria.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Skin and soft tissue infections, Bone and joint infections, Gonorrhea, Lyme disease
📋 Drug Information
| Generic Name(s) | Cefuroxime + Clavulanic Acid |
| Brand Name | Augxetil CV 500 Tablet |
| Manufacturer | Hetero Drugs Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin antibiotic + Beta-lactamase inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines cefuroxime, a bactericidal second-generation cephalosporin, with clavulanic acid, a beta-lactamase inhibitor. Cefuroxime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to inhibition of peptidoglycan cross-linking and subsequent bacterial lysis. Clavulanic acid irreversibly inhibits a wide range of beta-lactamase enzymes produced by bacteria, including those that would hydrolyze cefuroxime. By blocking these enzymes, clavulanic acid extends the spectrum of cefuroxime to include beta-lactamase-producing strains of Staphylococcus aureus, Haemophilus influenzae, Escherichia coli, Klebsiella species, and others. This combination is effective against many bacteria that are resistant to cefuroxime alone.
Mechanism Steps
💡 How to Take cfuro cv 250mg/125mg tablet
Strength: Immediate-release oral tablet containing 250 mg cefuroxime and 125 mg clavulanic acid.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet (250 mg cefuroxime + 125 mg clavulanic acid) taken orally twice daily, approximately every 12 hours, with food. For more severe infections, a higher strength may be prescribed. The duration of treatment depends on the type and severity of infection, typically 5 to 10 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific combination tablet. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced renal function and may require dose adjustment. Monitor renal function and adjust dose as needed. No specific dose adjustment is recommended solely based on age, but caution is advised. |
| Renal Impairment | In patients with renal impairment, dose adjustment is required. For creatinine clearance 10-30 mL/min, the usual dose may be reduced or the dosing interval extended. For creatinine clearance less than 10 mL/min, the drug should be used with caution and may require further dose reduction. Consult a clinician for individualized dosing. |
| Hepatic Impairment | No specific dose adjustment is recommended for hepatic impairment, but caution is advised due to the risk of clavulanic acid-associated hepatotoxicity. Monitor liver function. |
| Maximum Daily Dose | The maximum recommended daily dose is 500 mg cefuroxime and 250 mg clavulanic acid (two tablets of this strength) per day, unless otherwise prescribed by a clinician for severe infections. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cfuro cv 250mg/125mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate | |
| Loop diuretics | Moderate | |
| Aminoglycosides | Moderate | |
| Antacids | Minor | |
| H2 blockers | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Probenecid
⚡ Moderate Interactions
- Oral contraceptives
- Loop diuretics (e.g., furosemide)
- Aminoglycosides
🍷 Alcohol Interaction
Alcohol may worsen gastrointestinal side effects such as nausea, vomiting, and abdominal pain. It can also increase the risk of liver toxicity, especially with clavulanic acid. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to cefuroxime, clavulanic acid, or any other cephalosporin or beta-lactam antibiotic.","History of severe allergic reaction (e.g., anaphylaxis) to penicillins or other beta-lactams.","Use in patients with a history of cholestatic jaundice or hepatic dysfunction associated with prior use of this combination."]
⚠️ Warnings & Precautions
["Before starting therapy, inquire about previous allergic reactions to cephalosporins, penicillins, or other allergens.","Use with caution in patients with renal impairment; dose adjustment may be necessary.","Clavulanic acid can cause cholestatic hepatitis; discontinue if jaundice develops.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","Cefuroxime may cause seizures in patients with renal impairment; adjust dose.","Do not use for viral infections; it is ineffective and promotes resistance.","Complete the full course as prescribed, even if symptoms improve.","May interfere with certain laboratory tests (e.g., glucose oxidase tests for urine glucose)."]
🤱 Lactation Safety
Cefuroxime is excreted in breast milk in low concentrations and is generally considered compatible with breastfeeding. Clavulanic acid is also excreted in breast milk. Monitor the infant for diarrhea, thrush, or rash. Consult your doctor before use.
💊 Overdose Management
Overdose may cause nausea, vomiting, abdominal pain, and seizures, especially in patients with renal impairment. Treatment is symptomatic and supportive. Maintain adequate hydration. Cefuroxime can be removed by hemodialysis. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop treatment early, even if you feel better, because incomplete treatment can lead to bacterial resistance and relapse. Take this medicine with food to improve absorption and reduce stomach upset. Swallow the tablet whole with a glass of water; do not crush or chew it. Inform your doctor if you have kidney or liver problems, as dose adjustment may be needed. Avoid alcohol while taking this medicine because it can worsen stomach irritation and liver stress. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Do not share this medicine with others, even if they have similar symptoms. Keep this medicine out of reach of children. Store it at room temperature away from moisture and direct sunlight. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. If you experience signs of a severe allergic reaction such as swelling of the face, lips, or throat, difficulty breathing, or a widespread rash, seek emergency medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced renal function and may require dose adjustment. They are also at higher risk of Clavulanic acid-associated liver injury. Monitor renal and hepatic function closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. It is generally considered safe, but the combination with clavulanic acid should be used only if clearly needed.
🏥 Post-Surgery Considerations
This medicine may be prescribed to prevent or treat surgical site infections. Follow your surgeon's instructions regarding dosing and duration.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may be used for prophylaxis in certain dental procedures for patients at risk of infective endocarditis, but guidelines vary.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but if you experience dizziness, fatigue, or muscle pain, take rest. Avoid strenuous activities if you have fever or severe infection.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. If affected, avoid driving or operating heavy machinery. Otherwise, you can continue normal activities as tolerated.
🛑 When to Stop This Medicine
Stop taking this medicine only after completing the full prescribed course or as directed by your doctor. Do not stop early even if you feel better, as it can lead to recurrence and resistance. If you experience severe side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended unless prescribed for a specific chronic infection. Prolonged use can lead to bacterial resistance, superinfections, and rarely liver or kidney problems. Regular monitoring of renal and hepatic function may be required for extended therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another beta-lactam/beta-lactamase inhibitor combination with a similar spectrum.
Evidence: Well-establishedA third-generation cephalosporin combination with broader Gram-negative coverage.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics do not interfere with most vaccines. However, if you are scheduled for a live bacterial vaccine (e.g., typhoid Ty21a), consult your doctor as antibiotics may reduce its efficacy.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes. Store at room temperature and protect from moisture. If crossing time zones, adjust dosing times gradually to maintain even intervals. Check customs regulations for carrying prescription medicines. Carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 2 to 3 days, but it is important to complete the full course as prescribed.
A: Yes, take it with food to improve absorption and reduce stomach upset.
A: Take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose. Do not double dose.
A: Consult your doctor. It is generally considered safe when clearly needed, but the combination with clavulanic acid has limited data.
A: It is advisable to avoid alcohol as it can worsen side effects and increase liver stress.
🤔 Common Patient Concerns
🔄 Substitutes for cfuro cv 250mg/125mg tablet
View AllAlternative brands with exact same active ingredient:
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oratil cv 250 mg/125 mg syrupMacleods Pharmaceuticals Pvt Ltd ₹53.59 60% CHEAPER
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ceface cv 250 mg/125 mg tabletParenteral Drugs India Ltd ₹126.00 6% CHEAPER
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cefoxim cv 250mg/125mg tabletBiochem Pharmaceutical Industries ₹137.50 2.6% COSTLIER
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edrucef cv 250mg/125mg tabletAlna Biotech Pvt Ltd ₹140.63 4.9% COSTLIER
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bigcef-cv 375 tabletBestoChem Formulations India Ltd ₹150.00 11.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure viral infections like the common cold.
Fact: This medicine is effective only against bacterial infections. It does not treat viral infections. - Myth: You can stop taking antibiotics once you feel better.
Fact: You must complete the full prescribed course to prevent recurrence and resistance, even if symptoms improve. - Myth: Antibiotics weaken the immune system.
Fact: Antibiotics do not weaken the immune system; they target bacteria. However, they can disrupt normal flora, which may have temporary effects.
🔄 Alternative Options
Generic Alternatives
- Cefuroxime + Clavulanic Acid 250 mg + 125 mg tablet