cetral cold tablet - Paracetamol (NA) + Phenylpropanolamine (NA) medicine

cetral cold tablet

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🏭 Alembic Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

What is cetral cold tablet used for?

This medicine contains Paracetamol (NA) + Phenylpropanolamine (NA) and is used to treat RESPIRATORY. Paracetamol: Inhibits COX enzymes centrally, reducing prostaglandin synthesis. Phenylpropanolamine: . Always consult your doctor before use.

  • Generic Name: Paracetamol + Phenylpropanolamine
  • Manufacturer: Alembic Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 cetral cold tablet Uses & Benefits

Fever, headache, cold symptoms, nasal congestion.

Off-label uses: None established.

📋 Drug Information

Generic Name(s)Paracetamol + Phenylpropanolamine
Brand NameAnglocet Plus Tablet
ManufacturerAlembic Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAnalgesic, Antipyretic, Decongestant
Route of AdministrationOral
StorageStore at room temperature (15-30°C), protect from moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionParacetamol: Rapidly and completely absorbed from GI tract. Phenylpropanolamine: Well absorbed orally.
DistributionParacetamol: Widely distributed; crosses placenta. Phenylpropanolamine: Distributed throughout body; crosses blood-brain barrier.
Protein BindingParacetamol: 10-25%. Phenylpropanolamine: Not extensively bound.
MetabolismParacetamol: Hepatic via conjugation (glucuronidation, sulfation) and CYP450 (minor). Phenylpropanolamine: Hepatic via deamination and hydroxylation.
Half-LifeParacetamol: 1.5-3 hours. Phenylpropanolamine: 3-5 hours.
ExcretionParacetamol: Renal (mostly metabolites). Phenylpropanolamine: Renal (unchanged and metabolites).
BioavailabilityParacetamol: 60-90%. Phenylpropanolamine: ~100%.
Onset of ActionParacetamol: 30-60 min. Phenylpropanolamine: 15-30 min.
Peak Plasma TimeParacetamol: 30-60 min. Phenylpropanolamine: 1-2 hours.
Duration of ActionParacetamol: 4-6 hours. Phenylpropanolamine: 3-4 hours.

How It Works

Paracetamol: Inhibits COX enzymes centrally, reducing prostaglandin synthesis. Phenylpropanolamine: Alpha-1 adrenergic agonist causing vasoconstriction.

Mechanism Steps

1Paracetamol inhibits COX-1 and COX-2 in the CNS, reducing prostaglandin synthesis.
2Decreased prostaglandins lead to reduced pain perception and fever.
3Phenylpropanolamine activates alpha-1 adrenergic receptors on nasal blood vessels.
4Vasoconstriction reduces nasal congestion and swelling.

💡 How to Take cetral cold tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of cetral cold tablet

✅ Common Side Effects

Nausea
Dizziness
Insomnia
Dry mouth

🚨 Serious Side Effects

Hepatotoxicity
Hypertension
Arrhythmias
Allergic reactions

⚠️ Rare Side Effects

Thrombocytopenia
Agranulocytosis
Cerebral hemorrhage

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAOIs Major Hypertensive crisis
Warfarin Major Increased INR and bleeding risk
Alcohol Major Increased hepatotoxicity
Antihypertensives Moderate Reduced antihypertensive effect
Beta-blockers Moderate Hypertensive episode
Tricyclic antidepressants Moderate Enhanced sympathomimetic effect
Caffeine Minor Additive stimulation
Oral contraceptives Minor Reduced paracetamol metabolism

🚨 Major Interactions

  • MAOIs
  • Warfarin
  • Alcohol (chronic use)

⚡ Moderate Interactions

  • Antihypertensives
  • Beta-blockers
  • Tricyclic antidepressants

🍷 Alcohol Interaction

Chronic alcohol use increases hepatotoxicity risk of paracetamol.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, severe hypertension, coronary artery disease, MAOI use, hyperthyroidism.

🤱 Lactation Safety

Paracetamol safe; Phenylpropanolamine excreted in milk, use caution.

💊 Overdose Management

Activated charcoal, N-acetylcysteine for paracetamol; supportive care for phenylpropanolamine.

⏰ Missed Dose

Take as soon as remembered; skip if near next dose.

🔄 Substitutes for cetral cold tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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