cetgrain 20 mg/500 mg tablet
What is cetgrain 20 mg/500 mg tablet used for?
Anadom 10mg/500mg Tablet (Domperidone + Paracetamol) is used to treat NEURO CNS. It contains Domperidone (20mg) + Paracetamol (500mg), which Domperidone: Dopamine D2 receptor antagonist in CTZ and GI tract; Paracetamol: C. Always consult your doctor before use. Take as prescribed.
- Generic Name: Domperidone + Paracetamol
- Manufacturer: Pegasus Farmaco India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cetgrain 20 mg/500 mg tablet Uses & Benefits
๐ Drug Information
| Generic Name(s) | Domperidone + Paracetamol |
| Brand Name | Anadom 10mg/500mg Tablet |
| Manufacturer | Pegasus Farmaco India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Antiemetic + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Domperidone: Dopamine D2 receptor antagonist in CTZ and GI tract; Paracetamol: COX inhibition in CNS, possibly via TRPV1 and cannabinoid receptors.
Mechanism Steps
๐ก How to Take cetgrain 20 mg/500 mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cetgrain 20 mg/500 mg tablet
โ Common Side Effects
- Dry mouth
- Headache
- Dizziness
- Nausea
- Constipation
๐จ Serious Side Effects
- QT prolongation
- Torsades de pointes
- Hepatotoxicity
- Anaphylaxis
โ ๏ธ Rare Side Effects
- Galactorrhea
- Gynecomastia
- Extrapyramidal symptoms
- Blood dyscrasias
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| MAOIs | Major | Hypertensive crisis |
| Ketoconazole | Major | Increased domperidone levels, QT prolongation |
| QT-prolonging drugs | Major | Increased risk of arrhythmias |
| Anticholinergics | Moderate | Reduced GI motility |
| Opioids | Moderate | Reduced GI motility |
| Alcohol | Moderate | Increased hepatotoxicity risk |
| NSAIDs | Moderate | Increased nephrotoxicity risk |
| Chloramphenicol | Minor | Increased paracetamol half-life |
| Oral contraceptives | Minor | Reduced paracetamol efficacy |
๐จ Major Interactions
- Warfarin
- MAOIs
- CYP3A4 inhibitors (e.g., ketoconazole)
- QT-prolonging drugs
โก Moderate Interactions
- Anticholinergics
- Opioids
- Alcohol
- NSAIDs
โน๏ธ Minor Interactions
- Chloramphenicol
- Oral contraceptives
๐ฝ๏ธ Food Interactions
Domperidone: Food reduces absorption; Paracetamol: No significant effect.
๐ท Alcohol Interaction
Increased risk of hepatotoxicity with chronic alcohol use.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Domperidone: GI hemorrhage, perforation, prolactinoma; Paracetamol: Severe hepatic impairment.
๐ Monitoring Parameters
Liver function, ECG (QT interval), renal function.
๐คฑ Lactation Safety
Domperidone: Excreted in milk, avoid; Paracetamol: Safe in usual doses.
๐ Overdose Management
Paracetamol: N-acetylcysteine; Domperidone: Supportive care, ECG monitoring.
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double.
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Helpful and effective medicine as per my experience. Always consult a doctor.
Found this to be a helpful product. Good results.
This medicine was effective for me. I followed the doctor's advice.
Effective and reliable. Worked as expected.
Found this to be a helpful product. Good results.