Ampilox 100 mg/50 mg Drop: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swallowing
- Swelling of the face, lips, tongue, or throat
- Severe or bloody diarrhea
- Yellowing of the skin or eyes
- Severe abdominal pain
- High fever that does not improve after 48 hours of treatment
- Unusual bruising or bleeding
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is amclof 100mg/50mg capsule used for?
This medicine is a combination antibiotic oral drop containing ampicillin and cloxacillin, used to treat bacterial infections in children. It works by killing bacteria and is prescribed for infections of the respiratory tract, skin, and urinary tract. It should only be used under a doctor's supervision.
- Generic Name: Ampicillin + Cloxacillin
- Manufacturer: Ampra Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 amclof 100mg/50mg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा एम्पीसिलिन और क्लोक्सासिलिन का संयोजन है, जिसका उपयोग बच्चों में बैक्टीरियल संक्रमण के इलाज के लिए किया जाता है। यह निमोनिया, कान का संक्रमण, त्वचा संक्रमण, और मूत्र मार्ग संक्रमण जैसी बीमारियों में प्रभावी है। यह दवा बैक्टीरिया को मारकर काम करती है और इसे केवल डॉक्टर के निर्देशानुसार ही देना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, पेट दर्द और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी प्रतिक्रिया, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर त्वचा प्रतिक्रियाएं हो सकती हैं। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही दें। उपयोग से पहले बोतल को अच्छी तरह हिलाएं। सही मात्रा मापने के लिए दी गई ड्रॉपर का ही उपयोग करें। दवा का पूरा कोर्स पूरा करें, भले ही बच्चा बेहतर महसूस करे। बच्चे को पेनिसिलिन से एलर्जी हो तो यह दवा न दें। दवा को बच्चों की पहुंच से दूर रखें।
💊 amclof 100mg/50mg capsule Uses & Benefits
[{"condition":"Pediatric pneumonia","description":"Used to treat community-acquired pneumonia in children caused by susceptible Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus.","evidence":"Well-established"},{"condition":"Otitis media","description":"Effective against acute middle ear infections in children, especially when caused by ampicillin-susceptible organisms and penicillinase-producing staphylococci.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats cellulitis, impetigo, and abscesses caused by susceptible staphylococci and streptococci.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Used for uncomplicated UTIs in children when caused by susceptible Escherichia coli, Proteus mirabilis, or Enterococcus faecalis.","evidence":"Well-established"},{"condition":"Upper respiratory tract infections","description":"Prescribed for pharyngitis, tonsillitis, and sinusitis when bacterial etiology is confirmed or highly suspected.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Prophylaxis in dental procedures","description":"Sometimes used off-label for prevention of infective endocarditis in high-risk children undergoing dental work, though specific guidelines may recommend other regimens.","evidence":"Limited"},{"condition":"Neonatal sepsis","description":"May be used off-label in neonates for suspected sepsis when susceptible organisms are involved, but dosing and safety are not well established for this combination in this age group.","evidence":"Limited"}]
Primary treatment for: Bacterial infections in children
Also treats: Pneumonia, Otitis media, Skin infections, Urinary tract infections, Upper respiratory tract infections
📋 Drug Information
| Generic Name(s) | Ampicillin + Cloxacillin |
| Brand Name | Ampoxin 500 Capsule |
| Manufacturer | Ampra Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Penicillinase-resistant penicillin combination |
| Route of Administration | Oral |
| Storage | Store below 25°C in a dry place, protected from light. Do not freeze. Keep the bottle tightly closed. After reconstitution, store as directed on the label, usually for a specified number of days, and discard any unused portion after that period. |
| Shelf Life | Typically 24 months from the date of manufacture for the dry powder. After reconstitution, use within 7-14 days as specified by the manufacturer. Refer to the product label for exact expiration date. |
| WHO Guideline | Not established from the available information. The World Health Organization (WHO) does not specifically recommend this combination for any condition in its essential medicines list. Use should be guided by local antibiograms and clinical judgment. |
| ICMR Guideline | Not established from the available information. The Indian Council of Medical Research (ICMR) provides general guidance on antibiotic use, but specific recommendations for this combination are not available. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two penicillin antibiotics that inhibit bacterial cell wall synthesis. Ampicillin binds to penicillin-binding proteins (PBPs) and inhibits the transpeptidation step of peptidoglycan cross-linking, leading to weakened cell walls and bacterial lysis. Cloxacillin, being penicillinase-resistant, also binds to PBPs but is less susceptible to hydrolysis by beta-lactamases produced by Staphylococcus aureus, thus extending coverage against such strains. The combination provides a broader spectrum than either agent alone.
Mechanism Steps
💡 How to Take amclof 100mg/50mg capsule
Strength: Oral drops containing ampicillin 100 mg and cloxacillin 50 mg per specified volume (e.g., per mL or per dropperful). Refer to the product label for exact concentration.
Dosage Information
| Adult Dosage | This pediatric drop formulation is not intended for adults. Adult dosing of ampicillin/cloxacillin combinations varies widely based on the indication, severity of infection, and patient factors. Typical adult oral doses range from 250 mg to 500 mg of each component every 6 hours, but dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not use this drop formulation for adults without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific combination drop. Dosing must be determined by a pediatrician based on the child's age, weight, renal function, and the severity of the infection. Typically, the dose is calculated in mg/kg/day and divided into multiple doses. Do not self-medicate; consult a pediatrician. |
| Elderly Dosage | This drop formulation is not intended for elderly patients. For elderly adults, dosing should be individualized based on renal function, as penicillins are primarily excreted renally. Consult a clinician for appropriate dosing. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For creatinine clearance (CrCl) 10-50 mL/min, consider extending the dosing interval. For CrCl less than 10 mL/min, further reduce dose or increase interval. Consult a clinician for specific guidance. |
| Hepatic Impairment | No specific dose adjustment guidelines are established for hepatic impairment, but use with caution and monitor liver function, especially with cloxacillin. Consult a clinician. |
| Maximum Daily Dose | Not established from the available information for this pediatric drop formulation. The maximum daily dose must be determined by a qualified clinician based on the child's weight and clinical status. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of amclof 100mg/50mg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Methotrexate | Major | |
| Warfarin | Major | |
| Allopurinol | Major | |
| Oral contraceptives | Moderate | |
| Probenecid | Moderate | |
| Aminoglycosides | Moderate | |
| Antacids | Minor | |
| Laxatives | Minor |
🚨 Major Interactions
- Methotrexate
- Warfarin
- Allopurinol
⚡ Moderate Interactions
- Oral contraceptives
- Probenecid
- Aminoglycosides
🍷 Alcohol Interaction
Alcohol consumption is not recommended while taking this medicine, as it may worsen gastrointestinal side effects and potentially affect liver metabolism, especially with cloxacillin. It is best to avoid alcohol during the course of treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to penicillins or cephalosporins","History of severe allergic reaction (e.g., anaphylaxis) to beta-lactam antibiotics","Infectious mononucleosis (increased risk of rash with ampicillin)","Concurrent use with methotrexate (relative contraindication)"]
⚠️ Warnings & Precautions
["Use with caution in patients with renal impairment; dose adjustment may be required.","Use with caution in patients with hepatic impairment; monitor liver function.","May cause false-positive results in urine glucose tests using copper reduction methods.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","Serious allergic reactions, including anaphylaxis, can occur. Discontinue immediately if suspected.","Not effective against viral infections; do not use for common cold or flu.","Ensure adequate hydration during therapy."]
🤱 Lactation Safety
Ampicillin and cloxacillin are excreted in breast milk in low concentrations. Use with caution in nursing mothers. Monitor the infant for diarrhea, thrush, or allergic reactions. Consult a healthcare provider before breastfeeding while on this medicine.
💊 Overdose Management
Overdose may cause gastrointestinal symptoms such as nausea, vomiting, and diarrhea. In severe cases, neuromuscular excitability or seizures may occur, especially in patients with renal impairment. Treatment is symptomatic and supportive. Hemodialysis may be considered to remove ampicillin from the bloodstream in severe cases. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If a dose is missed, give it as soon as remembered. However, if it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose to catch up. Consult the prescribing doctor for specific guidance.
Additional Safety Advice
Always administer this medicine exactly as prescribed by the child's doctor. Shake the bottle well before each use to ensure uniform mixing of the suspension. Use the provided dropper or measuring device to measure the dose accurately; household spoons are not reliable. Do not give this medicine to a child who is allergic to penicillin or any other beta-lactam antibiotic. Inform the doctor if the child has kidney or liver problems, or a history of allergies or asthma. Complete the full course even if the child feels better after a few days, to prevent relapse and resistance. Do not save leftover medicine for future use. Keep out of reach of children. If a dose is missed, follow the missed dose instructions provided by your healthcare provider. Do not breastfeed if you are taking this medicine and have a hypersensitivity to penicillins, as it may pass into breast milk and affect the infant.
👴 Special Considerations for Elderly
💡 For Patients Above 65
This pediatric drop formulation is not intended for elderly patients. Elderly individuals may have reduced renal function and require dose adjustments if prescribed similar antibiotics. Consult a clinician.
🤰 Pregnancy Planning (TTC)
This medicine is not intended for use in pregnancy planning. If you are pregnant or planning to become pregnant, consult your doctor before using any medication. Penicillins are generally considered safe in pregnancy, but this specific combination should only be used if clearly needed.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery to prevent or treat surgical site infections in children. Follow the surgeon's instructions carefully. Monitor for signs of infection such as redness, swelling, or fever.
🦷 Dental Procedures
This medicine may be used prophylactically before dental procedures in children with certain heart conditions to prevent infective endocarditis. Consult the pediatrician or dentist for specific recommendations.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
There are no specific exercise restrictions while taking this medicine. However, if the child has a fever or feels unwell, allow them to rest and avoid strenuous activities until they recover.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is intended for pediatric use and does not directly impact adult work life. Parents may need to adjust schedules to administer doses at regular intervals. The child may need to stay home from school or daycare until they are no longer contagious and feeling well enough to return.
🛑 When to Stop This Medicine
Stop this medicine only after completing the full prescribed course or as directed by the doctor. Do not stop early, even if symptoms improve, to prevent relapse and resistance. If serious side effects occur, stop and seek medical advice immediately.
📅 Long-Term Use Effects
Long-term use of this medicine is not typically recommended. Prolonged use may lead to antibiotic resistance, superinfections, and rare side effects such as liver toxicity or blood dyscrasias. Regular monitoring of liver and kidney function may be required if therapy is extended. Always consult a doctor before using this medicine for more than the prescribed duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another antibiotic combination that may be used for similar infections, but with a different spectrum and side effect profile.
Evidence: Well-establishedAlternative antibiotics for patients allergic to penicillins, depending on the infection.
Evidence: Well-establishedFor viral infections, supportive care with fluids, rest, and fever reducers is appropriate.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics like this medicine do not interfere with the effectiveness of most vaccines. However, if the child is acutely ill with a fever, vaccination may be postponed until recovery. Consult the pediatrician for specific timing.
📦 Storage Guide
✅ DO
Store below 25°C in a dry place
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container with cap tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Discard after the expiration date or as directed after reconstitution
❌ DON'T
Do not use if the liquid changes color or contains particles
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label intact. Keep a copy of the prescription with you. Store the bottle in a cool, dry place, away from direct sunlight. If traveling by air, pack it in your carry-on luggage to avoid temperature extremes in checked baggage. For international travel, check customs regulations regarding antibiotics. If crossing time zones, adjust dosing times gradually, but consult your doctor for specific advice.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start to see improvement in your child's symptoms within 24 to 48 hours, but it is important to complete the full course as prescribed.
A: No, this medicine is an antibiotic and is not effective against viral infections like the common cold. It should only be used for bacterial infections as prescribed by a doctor.
A: If your child vomits within 30 minutes of taking the dose, consult your doctor or pharmacist for advice. Do not give another dose without medical guidance.
A: There are no specific food restrictions, but giving the medicine with food or milk can help reduce stomach upset. Avoid giving large amounts of grapefruit juice.
🤔 Common Patient Concerns
🔄 Substitutes for amclof 100mg/50mg capsule
View AllAlternative brands with exact same active ingredient:
-
megapen dropAristo Pharmaceuticals Pvt Ltd ₹19.50 50% CHEAPER
-
ampilox 100 mg/50 mg dropBiochem Pharmaceutical Industries ₹28.58 26.7% CHEAPER
-
ampilox c 100 mg/50 mg dropBiochem Pharmaceutical Industries ₹32.60 16.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the common cold.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: Once the child feels better, the medicine can be stopped.
Fact: It is essential to complete the full prescribed course to prevent relapse and antibiotic resistance. - Myth: This medicine is safe for anyone with a penicillin allergy.
Fact: This medicine contains penicillins and should be avoided in individuals with a known penicillin allergy.
🔄 Alternative Options
Generic Alternatives
- Ampicillin and cloxacillin oral drops (generic versions may be available)
Brand Alternatives
- Ampilox 100 mg/50 mg drop