cefoxitin 1000mg/500mg injection
What is cefoxitin 1000mg/500mg injection used for?
Befsul 1.5gm Injection (Cefepime + Sulbactam) is used to treat ANTI INFECTIVES. It contains Cefepime (1000mg) + Sulbactam (500mg), which Cefepime inhibits bacterial cell wall synthesis by binding to penicillin-binding. Always consult your doctor before use. Take as prescribed.
- Generic Name: Cefepime + Sulbactam
- Manufacturer: Capsutab Drugs Pvt Ltd
- Form: Allopathy
- Pregnancy Category: B
- Prescription Required: Yes
๐ cefoxitin 1000mg/500mg injection Uses & Benefits
Treatment of moderate to severe infections including pneumonia, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, and febrile neutropenia
Off-label uses: Meningitis, Osteomyelitis, Septic arthritis
๐ Drug Information
| Generic Name(s) | Cefepime + Sulbactam |
| Brand Name | Befsul 1.5gm Injection |
| Manufacturer | Capsutab Drugs Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) or intramuscular (IM) |
| Storage | Store at 20-25ยฐC; protect from light; reconstituted solution stable for 24 hours at room temperature or 7 days under refrigeration |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cefepime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); Sulbactam irreversibly inhibits beta-lactamases, protecting cefepime from degradation
Mechanism Steps
๐ก How to Take cefoxitin 1000mg/500mg injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cefoxitin 1000mg/500mg injection
โ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Injection site pain
๐จ Serious Side Effects
- Anaphylaxis
- Stevens-Johnson syndrome
- Clostridioides difficile colitis
- Acute kidney injury
- Seizures
โ ๏ธ Rare Side Effects
- Hemolytic anemia
- Agranulocytosis
- Thrombocytopenia
- Interstitial nephritis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Major | Increased nephrotoxicity risk |
| Loop diuretics | Major | Increased nephrotoxicity risk |
| Probenecid | Major | Decreased renal excretion of cefepime |
| Warfarin | Moderate | Increased INR and bleeding risk |
| Oral contraceptives | Moderate | Reduced contraceptive efficacy |
| Live vaccines | Moderate | Reduced vaccine efficacy |
| Antacids | Minor | Possible reduced absorption of sulbactam |
| Iron supplements | Minor | Possible reduced absorption of sulbactam |
๐จ Major Interactions
- Aminoglycosides
- Loop diuretics
- Probenecid
โก Moderate Interactions
- Warfarin
- Oral contraceptives
- Live vaccines
โน๏ธ Minor Interactions
- Antacids
- Iron supplements
๐ฝ๏ธ Food Interactions
No significant food interactions
๐ท Alcohol Interaction
No known interaction
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cefepime, sulbactam, or any cephalosporin; history of severe allergic reaction to penicillins
๐ Monitoring Parameters
Renal function, CBC, signs of hypersensitivity, superinfection
๐คฑ Lactation Safety
Excreted in breast milk in low amounts; use with caution
๐ Overdose Management
Supportive care; hemodialysis may enhance elimination
โฐ Missed Dose
Administer as soon as possible; do not double dose