cefos 500mg tablet - Cefuroxime (500mg) medicine

cefos 500mg tablet

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🏭 Osper Formulations Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

What is cefos 500mg tablet used for?

This medicine contains Cefuroxime (500mg) and is used to treat ANTI INFECTIVES. Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting . Always consult your doctor before use.

  • Generic Name: Cefuroxime
  • Manufacturer: Osper Formulations Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category B
  • Prescription Required: Yes
💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 cefos 500mg tablet Uses & Benefits

Upper and lower respiratory tract infections, urinary tract infections, skin and soft tissue infections, otitis media, sinusitis, gonorrhea, Lyme disease.

Off-label uses: Prophylaxis for surgical infections, treatment of bone and joint infections.

📋 Drug Information

Generic Name(s)Cefuroxime
Brand NameAltacef 500 Tablet
ManufacturerOsper Formulations Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassCephalosporins: 2nd generation
Route of AdministrationOral
StorageStore at room temperature (20-25°C); protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionWell absorbed after oral administration; food increases absorption.
DistributionDistributes widely into body tissues and fluids, including pleural fluid, synovial fluid, bone, and CSF (when meninges inflamed).
Protein Binding33-50%
MetabolismNot significantly metabolized; primarily renal excretion.
Half-Life1-2 hours
ExcretionRenal (80-90% unchanged in urine within 24 hours)
BioavailabilityApproximately 37% (oral); increased with food.
Onset of ActionRapid; within 1 hour for most infections.
Peak Plasma Time2-3 hours (oral)
Duration of ActionApproximately 8-12 hours

How It Works

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting transpeptidase and autolysin activity.

Mechanism Steps

1Cefuroxime binds to penicillin-binding proteins (PBPs) on bacterial cell wall.
2Inhibits transpeptidase enzyme, preventing cross-linking of peptidoglycan chains.
3Activates autolytic enzymes (autolysins) leading to cell wall lysis.
4Results in bactericidal effect against susceptible bacteria.

💡 How to Take cefos 500mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of cefos 500mg tablet

✅ Common Side Effects

Diarrhea
Nausea
Vomiting
Rash
Injection site reactions (if IV)

🚨 Serious Side Effects

Severe allergic reactions (anaphylaxis)
Clostridioides difficile diarrhea
Seizures (high doses)
Stevens-Johnson syndrome

⚠️ Rare Side Effects

Hemolytic anemia
Interstitial nephritis
Hepatitis
Agranulocytosis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk
Probenecid Major Decreased renal excretion of cefuroxime, increased levels
Live typhoid vaccine Major Reduced vaccine efficacy
BCG vaccine Major Reduced vaccine efficacy
Loop diuretics Moderate Increased nephrotoxicity risk
Aminoglycosides Moderate Increased nephrotoxicity risk
Oral contraceptives Moderate Reduced contraceptive efficacy
Antacids Minor Decreased absorption of cefuroxime
H2 antagonists Minor Decreased absorption of cefuroxime
Proton pump inhibitors Minor Decreased absorption of cefuroxime

🚨 Major Interactions

  • Warfarin
  • Probenecid
  • Live typhoid vaccine
  • BCG vaccine

⚡ Moderate Interactions

  • Loop diuretics
  • Aminoglycosides
  • Oral contraceptives
  • BCG (intravesical)

🍷 Alcohol Interaction

No known interaction; but may increase risk of disulfiram-like reaction (rare).

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to cefuroxime or other cephalosporins; previous immediate hypersensitivity reaction to penicillins.

🤱 Lactation Safety

Excreted in breast milk in small amounts; generally considered compatible with breastfeeding.

💊 Overdose Management

Supportive care; hemodialysis may enhance elimination.

⏰ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose and resume regular schedule. Do not double dose.

🔄 Substitutes for cefos 500mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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