wezcef 500mg tablet - Cefuroxime (500mg) medicine

Axicef 500mg Tablet: Complete Medicine Guide

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🏭 Wezen Chemicals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: High
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe or bloody diarrhoea
  • Swelling of the face, lips, or throat
  • Difficulty breathing or swallowing
  • Unusual bruising or bleeding
  • Severe skin rash with blisters or peeling
  • Decreased urine output or swelling in legs
  • Persistent high fever despite treatment

If experiencing severe symptoms, call emergency services immediately.

What is wezcef 500mg tablet used for?

This medicine is a cephalosporin antibiotic used to treat bacterial infections of the respiratory tract, urinary tract, skin, and soft tissues. It works by killing bacteria. Take it with food for better absorption and complete the full course as prescribed.

  • Generic Name: Cefuroxime (500mg)
  • Manufacturer: Wezen Chemicals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 wezcef 500mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा एक एंटीबायोटिक है जिसका उपयोग बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है, जैसे कि श्वसन तंत्र, मूत्र मार्ग, त्वचा और कोमल ऊतकों के संक्रमण। यह बैक्टीरिया को मारकर काम करती है। इसे भोजन के साथ लें और डॉक्टर द्वारा बताई गई पूरी अवधि तक लें।

साइड इफेक्ट्स: आम दुष्प्रभावों में दस्त, मतली, पेट दर्द, सिरदर्द और हल्के दाने शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें गंभीर एलर्जी प्रतिक्रिया, गंभीर दस्त, और रक्त विकार शामिल हो सकते हैं। यदि आपको गंभीर दस्त, चेहरे या गले में सूजन, सांस लेने में कठिनाई, या असामान्य खून बहना या चोट लगना हो, तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। पूरी अवधि तक लें, भले ही आप बेहतर महसूस करें। इसे भोजन के साथ लें। यदि आपको गुर्दे की समस्या है, तो डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। शराब से बचें। इसे किसी और के साथ साझा न करें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 wezcef 500mg tablet Uses & Benefits

[{"condition":"Upper respiratory tract infections","description":"Used to treat bacterial sinusitis, pharyngitis, and tonsillitis caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Lower respiratory tract infections","description":"Effective against community-acquired pneumonia and acute exacerbations of chronic bronchitis.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Treats uncomplicated urinary tract infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for uncomplicated skin infections such as cellulitis and impetigo.","evidence":"Well-established"},{"condition":"Gonorrhoea","description":"May be used as an alternative treatment for uncomplicated gonorrhoea.","evidence":"Established"},{"condition":"Lyme disease","description":"Effective in early Lyme disease and some later stages.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Prophylaxis in dental procedures","description":"Sometimes used to prevent infection in patients with certain heart conditions undergoing dental work.","evidence":"Limited"}]

Primary treatment for: Bacterial infections

Also treats: Respiratory tract infections, Urinary tract infections, Skin infections, Lyme disease, Gonorrhoea

📋 Drug Information

Generic Name(s)Cefuroxime (500mg)
Brand Namewezcef 500mg tablet
ManufacturerWezen Chemicals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassCephalosporins: 2nd generation
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to enhance absorption and reduce stomach upset.
2
Complete the full prescribed course even if you feel better after a few days.
3
Do not use this medicine for viral infections like the common cold or flu.
4
Inform your doctor if you are allergic to penicillin or other antibiotics.
5
Stay well hydrated while taking this medicine to help your kidneys flush it out.
6
Report any severe or bloody diarrhoea immediately, as it may be a sign of a serious intestinal infection.
7
Avoid alcohol while taking this medicine to prevent worsening of stomach side effects.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Fever with cough
This medicine is commonly prescribed for respiratory infections.
Likely Use
Burning urination
Used for urinary tract infections.
Likely Use
Runny nose without fever
This medicine is not effective for viral colds.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionCefuroxime axetil, the prodrug form in this tablet, is absorbed from the gastrointestinal tract after oral administration. Absorption is enhanced when taken with food. The bioavailability of the tablet is approximately 37% when taken with food, compared to lower bioavailability when taken on an empty stomach.
DistributionCefuroxime distributes widely into body tissues and fluids, including the respiratory tract, urine, bile, bone, and cerebrospinal fluid (when meninges are inflamed). It crosses the placenta and is excreted in breast milk.
Protein BindingApproximately 33% to 50% bound to plasma proteins.
MetabolismCefuroxime axetil is hydrolyzed by esterases in the intestinal mucosa and blood to release active cefuroxime. Cefuroxime itself is not significantly metabolized.
Half-LifeThe elimination half-life is approximately 1 to 2 hours in adults with normal renal function.
ExcretionCefuroxime is excreted primarily unchanged in the urine by glomerular filtration and tubular secretion. About 50% of an oral dose is recovered in urine within 24 hours.
BioavailabilityApproximately 37% when taken with food; lower when taken on an empty stomach.
Onset of ActionPeak plasma concentrations are reached within 2 to 3 hours after oral administration.
Peak Plasma Time2 to 3 hours
Duration of ActionThe duration of action is typically 8 to 12 hours, depending on the dose and the susceptibility of the infecting organism.

How It Works

Cefuroxime is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. This prevents the cross-linking of peptidoglycan chains, leading to a weakened cell wall and ultimately bacterial cell death.

Mechanism Steps

1
Binding to penicillin-binding proteins: Cefuroxime binds to specific penicillin-binding proteins located on the inner membrane of the bacterial cell wall.
2
Inhibition of cell wall synthesis: This binding inhibits the transpeptidation reaction required for cross-linking peptidoglycan chains, which are essential for cell wall strength.
3
Bacterial cell lysis: The weakened cell wall cannot withstand osmotic pressure, leading to cell lysis and death of the bacteria.

💡 How to Take wezcef 500mg tablet

Strength: 500 mg immediate-release tablet

1Take this medicine with food to improve absorption and reduce stomach upset.
2Swallow the tablet whole with a glass of water. Do not crush or chew.
3Take at evenly spaced intervals as prescribed by your doctor.
4Complete the full course of treatment, even if you feel better after a few days.
5Do not share this medicine with others.

Dosage Information

Adult DosageThe usual adult dose for most infections is 250 mg to 500 mg taken twice daily (every 12 hours) with food. For more severe infections or specific indications, your doctor may prescribe higher doses. The dose must be individualized by a qualified clinician based on the type and severity of infection, age, weight, renal and hepatic function. Always follow your doctor's prescription exactly.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children.
Elderly DosageElderly patients may have reduced renal function; dose adjustment may be necessary based on creatinine clearance. Consult your doctor.
Renal ImpairmentIn patients with renal impairment, dose adjustment is required. For creatinine clearance 10-20 mL/min, the usual dose may be given every 24 hours. For creatinine clearance less than 10 mL/min, the usual dose may be given every 48 hours. Consult your doctor for personalized dosing.
Hepatic ImpairmentNo specific dosage adjustment is required for hepatic impairment alone. However, caution is advised in patients with both hepatic and renal impairment.
Maximum Daily DoseThe maximum recommended adult dose is 1 gram per day for most infections, but may be higher for specific indications as determined by a clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Increases absorption and reduces stomach upset.
Grapefruit
No specific restriction
No significant interaction.

⏰ What to Do If You Miss a Dose

📌 Less than 6 hours since missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 6 hours since missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of wezcef 500mg tablet

✅ Common Side Effects

Diarrhoea (Common (5-10%))
Usually resolves on its own. Stay hydrated. Consult doctor if it persists or becomes severe.
Nausea (Common (5-10%))
Take with food to reduce nausea. Consult doctor if it continues.
Stomach pain (Common (5-10%))
Take with food. If pain is severe or persistent, consult your doctor.
Headache (Common (5-10%))
Usually resolves. Rest and hydration may help. Consult doctor if severe.
Mild skin rash (Uncommon (1-5%))
Monitor. If rash spreads or is accompanied by other symptoms, seek medical advice.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience swelling of the face, lips, throat, difficulty breathing, or a severe rash.
Clostridium difficile-associated diarrhoea (Rare (<0.1%))
Seek immediate medical attention if you develop severe, persistent, or bloody diarrhoea.
Blood disorders (e.g., neutropenia, thrombocytopenia) (Rare (<0.1%))
Report unusual bruising, bleeding, or signs of infection to your doctor promptly.
Severe skin reactions (e.g., Stevens-Johnson syndrome) (Very rare (<0.01%))
Seek immediate medical attention if you develop a painful rash, blisters, or peeling skin.

⚠️ Rare Side Effects

Seizures
Seek immediate medical attention.
Interstitial nephritis
Report decreased urine output, swelling, or flank pain to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Probenecid Major
Furosemide Moderate
Aminoglycosides Moderate
Oral contraceptives Minor

🚨 Major Interactions

  • Warfarin
  • Probenecid

⚡ Moderate Interactions

  • Loop diuretics (e.g., furosemide)
  • Aminoglycosides

🍷 Alcohol Interaction

Alcohol may worsen stomach upset and dizziness. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to cefuroxime or other cephalosporins","Previous severe allergic reaction to penicillins"]

⚠️ Warnings & Precautions

["Before starting, tell your doctor if you are allergic to penicillin or other antibiotics.","Use with caution in patients with kidney disease; dose adjustment may be needed.","Prolonged use may lead to overgrowth of non-susceptible organisms (superinfection).","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Do not use for viral infections; it is ineffective and may cause harm.","Complete the full course as prescribed, even if symptoms improve."]

🤱 Lactation Safety

Cefuroxime is excreted in breast milk in low concentrations. It is generally considered safe during breastfeeding, but monitor the infant for diarrhoea or thrush. Consult your doctor.

💊 Overdose Management

Overdose may cause nausea, vomiting, and diarrhoea. In severe cases, seizures may occur. Treatment is symptomatic and supportive. Hemodialysis may be considered in severe renal impairment. Contact a poison control center or emergency room immediately if overdose is suspected.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if you feel better. Complete the full course to prevent the infection from returning and to reduce the risk of antibiotic resistance. Take this medicine with food to improve absorption and reduce stomach upset. If you have kidney problems, your doctor may adjust the dose. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Avoid alcohol while taking this medicine as it may worsen stomach side effects. Do not share this medicine with anyone else. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may have reduced renal function and are more susceptible to side effects. Dose adjustment may be necessary based on kidney function. Monitor for signs of superinfection and renal impairment.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy or are pregnant, consult your doctor before taking this medicine. It is generally considered safe in pregnancy (Category B), but use only if clearly needed.

🏥 Post-Surgery Considerations

This medicine may be prescribed to prevent or treat surgical site infections. Follow your surgeon's instructions regarding dosing and duration. Inform your surgeon if you have any allergies.

🦷 Dental Procedures

This medicine may be used prophylactically before dental procedures in patients with certain heart conditions. Inform your dentist if you are allergic to penicillin or cephalosporins.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy diet rich in fruits and vegetables to support your immune system.
🥗
Stay well hydrated to help flush out bacteria and support kidney function.
😴
Get adequate rest to help your body fight the infection.
💧
Practice good hygiene, such as frequent handwashing, to prevent reinfection.
🧘
Avoid alcohol while taking this medicine to reduce stomach upset.
🌞
Complete the full course of antibiotics as prescribed, even if you feel better.

🏋️ Exercise Considerations

This medicine may cause dizziness in some people. Avoid strenuous exercise or activities requiring alertness until you know how it affects you. Mild exercise is generally safe if you feel well.

🥗 Diet Recommendations

Include probiotic-rich foods like yogurt to help maintain healthy gut bacteria.
Stay well hydrated by drinking plenty of water.
Avoid spicy and fatty foods if you experience stomach upset.
Eat small, frequent meals if you have nausea.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or tiredness in some people. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal daily activities, but take precautions if you feel unwell.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance. If you experience severe side effects, contact your doctor immediately for advice.

📅 Long-Term Use Effects

Long-term use of this medicine is not common and is generally limited to specific chronic infections. Prolonged use may lead to bacterial resistance and superinfection. Regular monitoring of renal and hepatic function may be advised. Always consult your doctor before extending treatment beyond the prescribed duration.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Probiotics

May help prevent antibiotic-associated diarrhoea.

Evidence: Moderate
Increased fluid intake

Helps flush out bacteria in urinary tract infections.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Antibiotics do not interact with vaccines. However, if you are scheduled for a live vaccine, inform your doctor as antibiotics may affect the immune response to certain vaccines. Generally, antibiotics are not a contraindication for vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes. If traveling across time zones, adjust dosing times gradually, but maintain the 12-hour interval as closely as possible. Store at room temperature and protect from moisture. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with a urinary tract infection
She was prescribed this medicine for a UTI. She took it with food twice daily as directed. Her symptoms improved within 3 days, but she completed the full 7-day course. She experienced mild nausea initially, which subsided after taking it with meals.
💡 Lesson: Taking the medicine with food reduces stomach upset, and completing the full course prevents recurrence.
👤 A 50-year-old man with chronic bronchitis
He was given this medicine for an acute exacerbation of chronic bronchitis. He noticed improvement in cough and breathing within 4 days. He was advised to avoid alcohol and to report if he developed severe diarrhoea. He completed the 10-day course and recovered fully.
💡 Lesson: Adherence to the prescribed duration and monitoring for side effects are key to successful treatment.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start feeling better within 2-3 days, but it is important to complete the full course as prescribed.

Q: Can I take it with food?

A: Yes, taking it with food improves absorption and reduces stomach upset.

Q: What if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for wezcef 500mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Antibiotics can cure viral infections like the common cold.
    Fact: Antibiotics only work against bacteria. They are ineffective against viruses.
  • Myth: You can stop taking antibiotics once you feel better.
    Fact: You must complete the full prescribed course to prevent recurrence and resistance.
  • Myth: Antibiotics weaken your immune system.
    Fact: Antibiotics do not weaken the immune system; they target bacteria.

🔄 Alternative Options

Generic Alternatives

  • Cefuroxime axetil 500 mg tablet

Brand Alternatives

  • Ceftin
  • Zinnat
  • Cefurax
  • Cefuroxime axetil

📊 Comparison with Similar Medicines

[{"medicine":"Cefuroxime","class":"2nd generation cephalosporin","spectrum":"Broad","common_use":"Respiratory, urinary, skin infections"},{"medicine":"Amoxicillin-clavulanate","class":"Penicillin + beta-lactamase inhibitor","spectrum":"Broad","common_use":"Respiratory, urinary, skin infections"},{"medicine":"Cefixime","class":"3rd generation cephalosporin","spectrum":"Broad","common_use":"Urinary, respiratory infections"}]

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