Ciractam 1.5gm Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe or persistent diarrhea
- Seizures or confusion
- Decreased urine output or swelling in the legs
- Yellowing of the skin or eyes
- Severe rash or blistering of the skin
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is cefitryp s 1000mg/500mg injection used for?
This medicine is a combination antibiotic injection containing cefpirome and sulbactam. It is used to treat serious bacterial infections in hospitals. It works by killing bacteria and is given intravenously by a healthcare professional.
- Generic Name: Cefpirome + Sulbactam
- Manufacturer: Alniche Life Sciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cefitryp s 1000mg/500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक संयुक्त एंटीबायोटिक इंजेक्शन है जिसमें सेफपिरोम और सल्बैक्टम शामिल हैं। इसका उपयोग अस्पताल में गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है, जैसे कि मूत्र पथ के संक्रमण, निमोनिया, त्वचा के संक्रमण, और रक्त के संक्रमण। यह दवा बैक्टीरिया को मारकर काम करती है और इसे एक योग्य स्वास्थ्य पेशेवर द्वारा नस के माध्यम से दिया जाता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, दाने, और इंजेक्शन की जगह पर दर्द या सूजन शामिल हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें तेज बुखार, सांस लेने में कठिनाई, चेहरे या गले में सूजन, और गंभीर दस्त शामिल हो सकते हैं। यदि आपको कोई भी गंभीर लक्षण महसूस हो, तो तुरंत अपने डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल एक योग्य स्वास्थ्य पेशेवर द्वारा अस्पताल या क्लिनिक में ही दी जानी चाहिए। इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों, विशेष रूप से गुर्दे की बीमारी, यकृत की बीमारी, या एंटीबायोटिक्स से एलर्जी के बारे में बताएं। अपने डॉक्टर को अपनी सभी दवाओं के बारे में भी बताएं। गर्भवती या स्तनपान कराने वाली महिलाओं को इस दवा का उपयोग करने से पहले अपने डॉक्टर से परामर्श करना चाहिए। संक्रमण को पूरी तरह से ठीक करने के लिए निर्धारित पूरा कोर्स पूरा करें।
💊 cefitryp s 1000mg/500mg injection Uses & Benefits
[{"condition":"Complicated urinary tract infections","description":"Used to treat serious kidney and bladder infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Lower respiratory tract infections","description":"Effective against hospital-acquired and community-acquired pneumonia caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats severe skin infections including cellulitis and abscesses caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Bloodstream infections (septicemia)","description":"Used in hospitalized patients with bacterial blood infections.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"May be used for complicated intra-abdominal infections in combination with other antibiotics.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Febrile neutropenia","description":"Sometimes used as empirical therapy in cancer patients with fever and low white blood cell counts.","evidence":"Limited"},{"condition":"Meningitis","description":"May be used off-label for bacterial meningitis due to its ability to penetrate the cerebrospinal fluid, but this is not a standard first-line use.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Complicated urinary tract infections, Lower respiratory tract infections, Skin and soft tissue infections, Bloodstream infections, Intra-abdominal infections
📋 Drug Information
| Generic Name(s) | Cefpirome + Sulbactam |
| Brand Name | Ciraclam |
| Manufacturer | Alniche Life Sciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) infusion or injection. It is administered by a healthcare professional, typically over 30 minutes for infusion or as a slow IV injection over 3-5 minutes |
| Storage | Store the unopened vial at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Once reconstituted, the solution should be used immediately or stored as directed by the manufacturer. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting bacterial cell wall synthesis. Cefpirome, a fourth-generation cephalosporin, binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, preventing the cross-linking of peptidoglycan strands. This weakens the cell wall and leads to bacterial cell lysis and death. Sulbactam is a beta-lactamase inhibitor that irreversibly binds to certain beta-lactamase enzymes produced by bacteria, protecting cefpirome from enzymatic degradation and extending its spectrum of activity against beta-lactamase-producing organisms.
Mechanism Steps
💡 How to Take cefitryp s 1000mg/500mg injection
Strength: Each vial contains cefpirome 1000 mg and sulbactam 500 mg as a sterile powder for reconstitution.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1.5 g (1000 mg cefpirome + 500 mg sulbactam) administered intravenously every 8 to 12 hours. The exact dose and frequency depend on the type and severity of the infection, the patient's kidney function, and clinical response. For severe infections, the dose may be increased to 3 g every 12 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function, which can increase the risk of side effects. Dosage should be adjusted based on creatinine clearance. Monitor renal function closely during therapy. |
| Renal Impairment | In patients with renal impairment, the dose of this medicine should be reduced and/or the dosing interval extended. For creatinine clearance 20-40 mL/min, the usual dose is 1.5 g every 12 hours; for creatinine clearance 10-20 mL/min, 1.5 g every 24 hours; for creatinine clearance less than 10 mL/min, 1.5 g every 48 hours. Dosage must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | No specific dosage adjustment is required for hepatic impairment alone. However, in patients with combined hepatic and renal impairment, careful monitoring and dose adjustment are advised. |
| Maximum Daily Dose | The maximum recommended daily dose is 6 g (cefpirome 4 g + sulbactam 2 g) per day, but this must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cefitryp s 1000mg/500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gentamicin | Major | |
| Furosemide | Major | |
| Warfarin | Major | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin)
- Loop diuretics (e.g., furosemide)
- Warfarin
⚡ Moderate Interactions
- Probenecid
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol does not directly interact with this medicine, but it may worsen side effects such as nausea, dizziness, or liver stress. It is advisable to avoid alcohol during treatment, especially if you have an underlying liver condition.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to cefpirome, sulbactam, or other beta-lactam antibiotics (penicillins, cephalosporins)","Previous anaphylactic reaction to any beta-lactam antibiotic","Use in patients with a history of severe allergic reactions to multiple allergens"]
⚠️ Warnings & Precautions
["Serious and occasionally fatal hypersensitivity reactions (anaphylaxis) have been reported. Before starting therapy, inquire about previous hypersensitivity to beta-lactams.","Clostridium difficile-associated diarrhea may occur during or after treatment. If diarrhea develops, evaluate for this condition.","Use with caution in patients with renal impairment; dosage adjustment is required.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi. Monitor for superinfection.","May cause seizures, especially in patients with renal impairment or underlying CNS disorders.","Safety and effectiveness in pediatric patients have not been fully established.","Use in pregnancy only if clearly needed; consult your doctor.","Caution when used in elderly patients due to age-related decline in renal function."]
🤱 Lactation Safety
Cefpirome and sulbactam are excreted in human milk in low amounts. Caution should be exercised when administered to a nursing woman. Consult your doctor to weigh the benefits of breastfeeding against the potential risks to the infant.
💊 Overdose Management
Overdose with this medicine may cause severe gastrointestinal symptoms, seizures, or renal impairment. There is no specific antidote. Treatment is supportive and symptomatic. In case of overdose, discontinue the medicine and consult a healthcare professional immediately. Hemodialysis may be considered to remove cefpirome from the blood in severe cases, but this is not well established.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional in a hospital or clinic setting, missed doses are unlikely. If you miss a scheduled dose, contact your healthcare provider as soon as possible. Do not attempt to self-administer an extra dose. Your doctor will determine the appropriate action based on the dosing schedule and your condition.
Additional Safety Advice
This medicine should only be administered by a qualified healthcare professional in a hospital or clinical setting. Before receiving this medicine, inform your doctor about all your medical conditions, especially kidney disease, liver disease, or any allergies to antibiotics. Tell your doctor about all other medicines you are taking, including prescription, over-the-counter, and herbal products, as this medicine can interact with other drugs. Do not breastfeed while receiving this medicine without consulting your doctor, as it may pass into breast milk. If you are pregnant or planning to become pregnant, discuss the risks and benefits with your doctor. Complete the full course of treatment as prescribed, even if you feel better, to prevent the infection from returning and to reduce the risk of antibiotic resistance. Report any new or worsening symptoms, especially severe diarrhea, rash, or difficulty breathing, to your healthcare provider immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can increase the risk of side effects. Dosage adjustment based on creatinine clearance is recommended. Monitor renal function closely.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. It should be used during pregnancy only if clearly needed. Effective contraception is recommended during treatment.
🏥 Post-Surgery Considerations
This medicine may be used to prevent or treat surgical site infections. It is administered intravenously in the hospital setting. Follow your surgeon's instructions regarding wound care and follow-up.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It may be used prophylactically before certain dental procedures in patients at risk of infective endocarditis, but this is determined by your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You may feel tired or dizzy while receiving this medicine. Avoid strenuous exercise until you feel fully recovered. Consult your doctor before resuming intense physical activity.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so you will likely need to take time off work during treatment. You may feel tired or unwell, so rest is important. Avoid driving or operating machinery if you feel dizzy or drowsy.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early can lead to incomplete treatment and antibiotic resistance. Your doctor will determine when to stop based on your clinical response and test results.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance and superinfections. Prolonged therapy may also increase the risk of kidney or liver problems. Regular monitoring of renal and hepatic function is recommended for patients on extended treatment. When used appropriately for short courses, long-term effects are minimal.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For less severe infections, oral antibiotics may be used instead of intravenous therapy.
Evidence: Well-establishedDepending on the causative organism and susceptibility, other antibiotics may be more appropriate.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, antibiotics may reduce the effectiveness of live bacterial vaccines like typhoid vaccine. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered in a hospital or clinic setting, so travel is not applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as directed and keep it in its original packaging. Consult your doctor before traveling if you have any concerns.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working immediately after administration, but you may not feel better for 1-2 days. Complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic.
A: Avoid alcohol and inform your doctor about all other medicines you are taking.
🤔 Common Patient Concerns
🔄 Substitutes for cefitryp s 1000mg/500mg injection
View AllAlternative brands with exact same active ingredient:
-
ciractam 1.5gm injectionConverge Biotech ₹1,124.06 2.3% CHEAPER
-
fumiget 1000mg/500mg injectionFusion Healthcare Pvt Ltd ₹1,265.63 10.1% COSTLIER
-
eprom s 1.5 injectionEvans Healthcare ₹1,682.81 46.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and is only effective against bacterial infections, not viruses. - Myth: You can stop the medicine as soon as you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to avoid antibiotic resistance. - Myth: This medicine is safe to use without a prescription.
Fact: This is a prescription medicine and must only be used under the supervision of a qualified healthcare professional.
🔄 Alternative Options
Generic Alternatives
- Cefpirome + Sulbactam injection
Brand Alternatives
- Ciractam 1.5gm injection