cefest 500mg injection - Uses, Price, Side Effects & Substitutes
What is cefest 500mg injection used for?
Antax 1gm Injection (Cefotaxime) is used to treat ANTI INFECTIVES. It contains Cefotaxime (500mg), which Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. Always consult your doctor before use. Take as prescribed.
- Generic Name: Cefotaxime
- Manufacturer: Parex Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: B
- Prescription Required: Yes
๐ cefest 500mg injection Uses & Benefits
Treatment of lower respiratory tract infections, urinary tract infections, septicemia, intra-abdominal infections, gynecologic infections, bone and joint infections, skin and soft tissue infections, meningitis, and surgical prophylaxis.
Off-label uses: Lyme disease, Typhoid fever, Empiric therapy in febrile neutropenia
๐ Drug Information
| Generic Name(s) | Cefotaxime |
| Brand Name | Antax 1gm Injection |
| Manufacturer | Parex Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporins: 3 generation |
| Route of Administration | Intramuscular or intravenous injection. |
| Storage | Store at 20-25ยฐC (68-77ยฐF). Protect from light. Reconstituted solution stable for 24 hours at room temperature and 48 hours under refrigeration. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting transpeptidation, and activating autolytic enzymes.
Mechanism Steps
๐ก How to Take cefest 500mg injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cefest 500mg injection
โ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Injection site reactions (pain, induration)
- Rash
- Eosinophilia
๐จ Serious Side Effects
- Severe hypersensitivity reactions (anaphylaxis)
- Clostridioides difficile-associated diarrhea
- Seizures
- Hemolytic anemia
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Pseudomembranous colitis
- Interstitial nephritis
- Agranulocytosis
- Thrombocytopenia
- Hepatitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Probenecid | Major | Decreased renal excretion of cefotaxime, increased plasma levels and toxicity risk. |
| Aminoglycosides | Major | Increased risk of nephrotoxicity and ototoxicity. |
| Loop diuretics | Major | Increased risk of nephrotoxicity. |
| Oral anticoagulants | Moderate | Enhanced anticoagulant effect, increased bleeding risk. |
| Live typhoid vaccine | Moderate | Reduced immunological response to vaccine. |
| BCG vaccine | Moderate | Reduced efficacy of BCG vaccine. |
| Tetracyclines | Minor | Possible antagonism of bactericidal effect. |
| Chloramphenicol | Minor | Possible antagonism of bactericidal effect. |
๐จ Major Interactions
- Probenecid
- Aminoglycosides
- Loop diuretics
โก Moderate Interactions
- Oral anticoagulants
- Live typhoid vaccine
- BCG vaccine
โน๏ธ Minor Interactions
- Tetracyclines
- Chloramphenicol
๐ฝ๏ธ Food Interactions
No significant food interactions (parenteral drug).
๐ท Alcohol Interaction
May cause disulfiram-like reaction (nausea, vomiting, headache) if alcohol consumed within 48 hours after administration.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cefotaxime, other cephalosporins, or any component of the formulation. History of severe immediate hypersensitivity reaction to penicillins or other beta-lactams.
๐ Monitoring Parameters
Renal function, hepatic function, complete blood count, signs of superinfection, and hypersensitivity reactions.
๐คฑ Lactation Safety
Cefotaxime is excreted in breast milk in low concentrations; caution advised. Generally considered c
๐ Overdose Management
Supportive care. Hemodialysis may enhance elimination. Monitor for seizures and renal function.
โฐ Missed Dose
Administer as soon as possible. If close to next dose, skip missed dose and resume regular schedule. Do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for cefest 500mg injection
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Medical Note: Always consult your doctor before switching medications.