caviter fd tablet 225mg/150mg - Rifampicin (225mg) + Isoniazid (150mg) medicine

Caviter FD Tablet 225mg/150mg: Complete Medicine Guide

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🏭 Wockhardt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: High
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Yellowing of eyes or skin
  • Dark urine or pale stools
  • Severe abdominal pain
  • Persistent vomiting
  • Numbness or tingling in hands or feet
  • Vision changes
  • Swelling of face, lips, or throat
  • Difficulty breathing

If experiencing severe symptoms, call emergency services immediately.

What is caviter fd tablet 225mg/150mg used for?

This medicine is a combination of rifampicin and isoniazid used to treat tuberculosis. It works by killing the bacteria that cause the infection. It must be taken exactly as prescribed, usually on an empty stomach, and the full course must be completed to prevent resistance.

  • Generic Name: Rifampicin + Isoniazid
  • Manufacturer: Wockhardt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 caviter fd tablet 225mg/150mg के बारे में (Hindi Summary)

उपयोग: यह दवा रिफैम्पिसिन और आइसोनियाजिड का संयोजन है, जिसका उपयोग तपेदिक (टीबी) के इलाज के लिए किया जाता है। यह बैक्टीरिया को मारकर संक्रमण को फैलने से रोकती है। यह दवा आमतौर पर खाली पेट ली जाती है और पूरा कोर्स पूरा करना जरूरी है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट खराब, भूख न लगना और थकान शामिल हैं। पेशाब, पसीना और आंसू का रंग नारंगी-लाल हो सकता है, जो हानिरहित है। गंभीर दुष्प्रभावों में यकृत की सूजन, तंत्रिका क्षति और एलर्जी प्रतिक्रिया शामिल हैं। कोई भी गंभीर लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को हमेशा खाली पेट, भोजन से कम से कम एक घंटा पहले या दो घंटे बाद, एक गिलास पानी के साथ लें। इलाज बीच में न रोकें, अन्यथा दवा प्रतिरोधी टीबी हो सकती है। शराब का सेवन पूरी तरह बंद कर दें। यकृत की कार्यप्रणाली की नियमित जांच कराएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 caviter fd tablet 225mg/150mg Uses & Benefits

[{"condition":"Active pulmonary tuberculosis","description":"Used as part of a combination regimen to treat tuberculosis affecting the lungs.","evidence":"Well-established"},{"condition":"Extrapulmonary tuberculosis","description":"Effective against tuberculosis in other organs such as lymph nodes, bones, or meninges, when combined with other drugs.","evidence":"Well-established"},{"condition":"Latent tuberculosis infection","description":"Sometimes used to prevent progression to active disease in high-risk individuals, but only under specialist guidance.","evidence":"Established in specific scenarios"}]

Off-label uses: [{"condition":"Atypical mycobacterial infections","description":"Occasionally used for infections caused by non-tuberculous mycobacteria, but not a standard first-line option.","evidence":"Limited"},{"condition":"Leprosy","description":"Rifampicin is part of multidrug therapy for leprosy, but this specific combination is not typically used.","evidence":"Established for rifampicin alone"}]

Primary treatment for: Tuberculosis

Also treats: Latent tuberculosis infection, Extrapulmonary tuberculosis

📋 Drug Information

Generic Name(s)Rifampicin + Isoniazid
Brand NameAkt 2 Tablet
ManufacturerWockhardt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassAntimycobacterials
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineThe World Health Organization recommends rifampicin and isoniazid as first-line agents for the treatment of drug-susceptible tuberculosis. This fixed-dose combination is included in WHO guidelines for the intensive phase of therapy.
ICMR GuidelineThe Indian Council of Medical Research recommends this combination as part of the standard regimen for tuberculosis under the Revised National Tuberculosis Control Program (RNTCP).

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine on an empty stomach to maximize absorption.
2
Monitor liver function tests regularly, as both drugs can affect the liver.
3
Advise patients to avoid alcohol completely during treatment.
4
Consider pyridoxine supplementation to prevent peripheral neuropathy.
5
Warn patients about harmless reddish-orange discoloration of body fluids.
6
Emphasize the importance of completing the full course to prevent resistance.
7
Check for drug interactions, especially with anticoagulants and antiretrovirals.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Persistent cough for more than 2 weeks
This medicine is used to treat tuberculosis, which often presents with chronic cough.
Likely Use
✅
Fever
Tuberculosis can cause fever, and this medicine helps treat the underlying infection.
Likely Use
❌
Common cold
This medicine is not effective against viral infections like the common cold.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRifampicin is well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring 2 to 4 hours after oral administration. Isoniazid is also rapidly absorbed, with peak levels within 1 to 2 hours. Food can delay absorption, so this medicine should be taken on an empty stomach.
DistributionRifampicin is highly lipophilic and distributes widely into body tissues and fluids, including cerebrospinal fluid, lungs, and liver. Isoniazid also distributes widely, crossing the blood-brain barrier and placenta. Both drugs are present in breast milk.
Protein BindingRifampicin is approximately 80% bound to plasma proteins. Isoniazid is only about 10% to 15% protein-bound.
MetabolismRifampicin is metabolized in the liver, primarily by deacetylation, and undergoes enterohepatic circulation. Isoniazid is acetylated in the liver by N-acetyltransferase 2 (NAT2), with genetic variations affecting the rate of metabolism.
Half-LifeThe elimination half-life of rifampicin is approximately 3 to 4 hours, and it may shorten with repeated dosing due to enzyme induction. Isoniazid has a half-life of 1 to 4 hours, depending on acetylator status.
ExcretionRifampicin is excreted mainly in bile and feces, with a small amount in urine. Isoniazid is excreted primarily in urine as unchanged drug and metabolites.
BioavailabilityRifampicin has a bioavailability of about 90% to 95% when taken on an empty stomach. Isoniazid bioavailability is approximately 90%.
Onset of ActionThe onset of antibacterial action is gradual, typically within a few hours of administration, but clinical improvement in tuberculosis may take weeks.
Peak Plasma TimeRifampicin peak plasma concentration occurs 2 to 4 hours after oral intake. Isoniazid peaks at 1 to 2 hours.
Duration of ActionThe antibacterial effect persists for approximately 24 hours, allowing for once-daily dosing in most regimens.

How It Works

This medicine combines two antitubercular drugs with distinct mechanisms. Rifampicin inhibits bacterial DNA-dependent RNA polymerase, preventing the synthesis of messenger RNA and thereby stopping protein production in Mycobacterium tuberculosis. Isoniazid is a prodrug activated by bacterial catalase-peroxidase; it then inhibits mycolic acid synthesis, which is essential for the bacterial cell wall. The combination is synergistic and helps prevent the emergence of resistant strains.

Mechanism Steps

1
Rifampicin entry and RNA polymerase binding: Rifampicin penetrates the bacterial cell and binds to the beta subunit of DNA-dependent RNA polymerase, blocking the elongation of RNA chains.
2
Isoniazid activation: Isoniazid is activated by the bacterial enzyme KatG into a reactive species that inhibits InhA, a key enzyme in mycolic acid synthesis.
3
Cell wall disruption: Inhibition of mycolic acid weakens the bacterial cell wall, leading to cell lysis and death.
4
Synergistic killing: The combined action of rifampicin and isoniazid results in rapid killing of Mycobacterium tuberculosis and reduces the chance of resistance.

💡 How to Take caviter fd tablet 225mg/150mg

Strength: Tablet containing rifampicin 225 mg and isoniazid 150 mg.

1Take this medicine on an empty stomach, at least 1 hour before or 2 hours after a meal.
2Swallow the tablet whole with a full glass of water.
3Do not crush, chew, or break the tablet unless advised by your doctor.
4Take at the same time each day to maintain consistent blood levels.
5If you experience stomach upset, consult your doctor before taking with food.
6Do not skip doses; complete the full course as prescribed.

Dosage Information

Adult DosageThe dosage of this medicine is individualized by a qualified clinician based on the patient's weight, age, renal and hepatic function, and the specific type of tuberculosis. Typically, rifampicin is dosed at 10 mg/kg and isoniazid at 5 mg/kg daily, but this combination tablet provides fixed amounts. It is usually taken once daily on an empty stomach. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may require dose adjustments due to reduced liver and kidney function. Close monitoring is advised. Dose must be individualized by a qualified clinician.
Renal ImpairmentDose adjustment may be needed in patients with severe renal impairment. Consult a clinician for individualized dosing.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction or alternative regimens may be necessary. Regular monitoring of liver function is essential.
Maximum Daily DoseThe maximum daily dose should not exceed the recommended therapeutic dose as determined by a clinician. Typically, rifampicin 600 mg and isoniazid 300 mg daily, but this combination provides lower doses per tablet.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take on an empty stomach
Food reduces absorption of rifampicin.
Tyramine-rich foods
Avoid
May cause hypertensive crisis with isoniazid.
Alcohol
Avoid
Increases risk of liver damage.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours since missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 12 hours since missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of caviter fd tablet 225mg/150mg

✅ Common Side Effects

Nausea and vomiting (Common (5-10%))
Take with a small snack if approved by your doctor, and stay hydrated. If persistent, consult your doctor.
Reddish-orange discoloration of urine, sweat, tears (Very common (>10%))
This is harmless and expected. Do not be alarmed, but avoid wearing contact lenses as they may stain.
Loss of appetite (Common (5-10%))
Eat small, frequent meals. Consult your doctor if it persists.
Fatigue (Common (5-10%))
Get adequate rest. If severe, inform your doctor.

🚨 Serious Side Effects

Hepatitis (liver inflammation) (Uncommon (0.1-1%))
Seek immediate medical attention if you notice yellowing of eyes or skin, dark urine, or severe abdominal pain.
Peripheral neuropathy (Uncommon (0.1-1%))
Report numbness, tingling, or burning in hands or feet to your doctor. May require pyridoxine supplementation.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency care if you experience swelling of face, lips, throat, difficulty breathing, or widespread rash.
Blood disorders (e.g., thrombocytopenia, leukopenia) (Rare (<0.1%))
Report unusual bleeding, bruising, or signs of infection to your doctor immediately.

⚠️ Rare Side Effects

Renal failure
Seek immediate medical attention if you notice decreased urine output or swelling.
Optic neuritis
Report vision changes or eye pain to your doctor promptly.
Psychosis
Seek immediate medical help if you experience confusion, hallucinations, or severe mood changes.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Protease inhibitors Major
Oral contraceptives Major
Ketoconazole Major
Phenytoin Moderate
Haloperidol Moderate
Diazepam Moderate
Antacids Minor
Tyramine-rich foods Moderate
Alcohol Major

🚨 Major Interactions

  • Warfarin
  • Protease inhibitors (e.g., ritonavir)
  • Oral contraceptives
  • Ketoconazole

⚡ Moderate Interactions

  • Phenytoin
  • Haloperidol
  • Diazepam

🍷 Alcohol Interaction

Alcohol should be completely avoided while taking this medicine. Both rifampicin and isoniazid can cause liver damage, and alcohol significantly increases this risk. Alcohol may also worsen side effects like dizziness and nausea.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to rifampicin or isoniazid","Severe hepatic impairment","Acute liver disease","Concurrent use with certain protease inhibitors or other contraindicated drugs","History of drug-induced hepatitis"]

⚠️ Warnings & Precautions

["Monitor liver function closely; discontinue if signs of hepatitis occur.","Use with caution in patients with diabetes, as isoniazid may affect blood sugar control.","Peripheral neuropathy risk; pyridoxine supplementation may be needed.","Rifampicin may cause discoloration of body fluids; this is harmless.","May reduce effectiveness of oral contraceptives; use backup contraception.","Avoid alcohol consumption.","Use with caution in patients with seizure disorders."]

🤱 Lactation Safety

Both rifampicin and isoniazid are excreted in breast milk. While the amounts are generally not harmful to the infant, monitoring for side effects is advised. Breastfeeding should be continued unless otherwise directed by a doctor.

💊 Overdose Management

Overdose can cause nausea, vomiting, abdominal pain, lethargy, and liver damage. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor liver and kidney function.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Always take this medicine on an empty stomach, at least one hour before or two hours after meals, with a full glass of water. Do not skip doses or stop treatment early, as this can lead to drug-resistant tuberculosis. Avoid alcohol completely while on this medicine because it increases the risk of liver damage. Inform your doctor if you have a history of liver disease, kidney disease, diabetes, or alcohol use. Your doctor will likely monitor your liver function with blood tests before and during treatment. If you are pregnant or breastfeeding, discuss the risks and benefits with your doctor. This medicine can make hormonal contraceptives less effective, so use an additional barrier method. Do not share this medicine with anyone else, even if they have similar symptoms.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of liver toxicity and peripheral neuropathy. Close monitoring and dose adjustments may be necessary.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor. This medicine is generally considered safe in pregnancy when needed for tuberculosis, but specialist guidance is essential.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist about this medicine before any surgery. It may interact with anesthetic agents and affect liver function.

🦷 Dental Procedures

Inform your dentist about this medicine before any dental procedure. It may increase the risk of bleeding and interact with certain medications used in dentistry.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy diet rich in fruits and vegetables.
🥗
Avoid alcohol completely.
😴
Get plenty of rest to support recovery.
💧
Practice good hygiene to prevent spreading infection.
🧘
Take prescribed supplements like pyridoxine if recommended.
🌞
Stay hydrated by drinking plenty of water.

🏋️ Exercise Considerations

Moderate exercise is generally safe, but avoid strenuous activities if you feel fatigued or dizzy. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Eat a balanced diet with adequate protein.
Include foods rich in B vitamins to prevent neuropathy.
Avoid tyramine-rich foods like aged cheese and cured meats.
Stay well hydrated.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or fatigue, which can affect your ability to drive or operate machinery. Avoid driving until you know how the medicine affects you. Take adequate rest and follow your doctor's advice regarding work.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. Treatment must be completed as prescribed. If you experience severe side effects, contact your doctor immediately for guidance.

📅 Long-Term Use Effects

Long-term use of this medicine is generally safe when monitored appropriately. However, prolonged use can increase the risk of liver toxicity and peripheral neuropathy. Regular liver function tests and clinical monitoring are essential. Most side effects are reversible upon discontinuation.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Directly Observed Therapy (DOT)

A healthcare worker observes the patient taking each dose to ensure adherence.

Evidence: Well-established
Nutritional support

Adequate nutrition helps improve treatment outcomes.

Evidence: Established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine may reduce the effectiveness of certain vaccines, such as BCG. Consult your doctor regarding vaccination schedules while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from direct sunlight. If crossing time zones, adjust dosing times gradually in consultation with your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man diagnosed with pulmonary tuberculosis
He was prescribed this medicine as part of his TB regimen. Initially, he was alarmed by the orange discoloration of his urine, but his doctor reassured him. He took the medicine regularly on an empty stomach and completed the six-month course. His sputum tests became negative after two months, and he recovered fully.
💡 Lesson: Adherence to the prescribed regimen and understanding harmless side effects are key to successful treatment.
👤 A 50-year-old woman with diabetes and latent TB
She was started on this medicine for latent TB. She developed tingling in her feet, which was identified as peripheral neuropathy. Her doctor added pyridoxine, and the symptoms improved. She completed the treatment without further issues.
💡 Lesson: Regular monitoring and prompt reporting of new symptoms can help manage side effects effectively.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start feeling better within a few weeks, but it is essential to complete the full course, which typically lasts 6 months or more, to fully cure the infection.

Q: Can I stop taking this medicine if I feel better?

A: No, you must complete the entire prescribed course. Stopping early can lead to relapse and drug-resistant tuberculosis.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose. Do not double dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my liver?
  • Can I drive after taking this medicine?
  • Does it interact with my diabetes medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for caviter fd tablet 225mg/150mg

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Tuberculosis treatment can be stopped once symptoms improve.
    Fact: Treatment must be completed as prescribed to prevent relapse and drug resistance.
  • Myth: This medicine causes permanent discoloration of urine.
    Fact: The reddish-orange discoloration is temporary and harmless; it resolves after treatment ends.
  • Myth: This medicine can be taken with alcohol.
    Fact: Alcohol increases the risk of liver damage and should be avoided.

🔄 Alternative Options

Generic Alternatives

  • Rifampicin and isoniazid combination tablets from other manufacturers

Brand Alternatives

  • Rifampicin and isoniazid combination tablets from other manufacturers

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Rifampicin 225 mg + Isoniazid 150 mg","use":"Intensive phase of tuberculosis","notes":"Fixed-dose combination"},{"medicine":"Rifampicin, isoniazid, pyrazinamide, ethambutol","composition":"Rifampicin 150 mg + Isoniazid 75 mg + Pyrazinamide 400 mg + Ethambutol 275 mg","use":"Intensive phase of tuberculosis","notes":"Quadruple combination"}]

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