cataderm g cream - Clobetasol (NA) + Gentamicin (NA) medicine

cataderm g cream

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🏭 Anhox Healthcare Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

What is cataderm g cream used for?

This medicine contains Clobetasol (NA) + Gentamicin (NA) and is used to treat DERMA. Clobetasol: Anti-inflammatory via glucocorticoid receptor binding; Gentamicin: Bactericidal by bindi. Always consult your doctor before use.

  • Generic Name: Clobetasol + Gentamicin
  • Manufacturer: Anhox Healthcare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 cataderm g cream Uses & Benefits

Inflammatory dermatoses with secondary bacterial infection, e.g., eczema, psoriasis, contact dermatitis.

Off-label uses: Lichen planus, discoid lupus erythematosus.

📋 Drug Information

Generic Name(s)Clobetasol + Gentamicin
Brand NameCosvate-GM Cream
ManufacturerAnhox Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassCorticosteroid + Antibiotic
Route of AdministrationTopical
StorageStore at 20-25°C; protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionTopical absorption varies; enhanced by inflamed skin or occlusive dressings.
DistributionDistributes locally; systemic absorption minimal with intact skin.
Protein BindingClobetasol: 98% bound; Gentamicin: low protein binding.
MetabolismClobetasol: Hepatic via CYP3A4; Gentamicin: Not metabolized.
Half-LifeClobetasol: ~2-3 hours; Gentamicin: ~2-3 hours (topical).
ExcretionClobetasol: Renal and biliary; Gentamicin: Renal (unchanged).
BioavailabilityLow systemic bioavailability with topical application.
Onset of ActionWithin a few days of regular application.
Peak Plasma TimeNot applicable for topical use; minimal systemic levels.
Duration of ActionVaries; typically 12-24 hours with twice-daily application.

How It Works

Clobetasol: Anti-inflammatory via glucocorticoid receptor binding; Gentamicin: Bactericidal by binding to 30S ribosomal subunit.

Mechanism Steps

1Clobetasol binds to glucocorticoid receptor, inducing anti-inflammatory proteins.
2Gentamicin binds to 30S ribosomal subunit, inhibiting protein synthesis in bacteria.
3Combined effect reduces inflammation and eradicates susceptible bacteria.

💡 How to Take cataderm g cream

Follow your doctor's prescription exactly.

⚠️ Side Effects of cataderm g cream

✅ Common Side Effects

Burning
itching
irritation
dryness

🚨 Serious Side Effects

Adrenal suppression
Cushing's syndrome
Skin atrophy
Secondary infection

⚠️ Rare Side Effects

Allergic contact dermatitis
Hypopigmentation
Perioral dermatitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Aminoglycosides Major Increased nephrotoxicity and ototoxicity risk
Neuromuscular blocking agents Major Enhanced neuromuscular blockade
Loop diuretics Moderate Increased ototoxicity risk
Amphotericin B Moderate Increased nephrotoxicity risk
Other topical corticosteroids Minor Additive local effects

🚨 Major Interactions

  • Aminoglycosides
  • Neuromuscular blocking agents

⚡ Moderate Interactions

  • Loop diuretics
  • Amphotericin B

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to components, untreated bacterial/fungal/viral infections, skin ulcers, rosacea, perioral dermatitis.

🤱 Lactation Safety

Use with caution; avoid application to breast area.

💊 Overdose Management

Topical overdose unlikely; discontinue use and treat symptomatically.

⏰ Missed Dose

Apply as soon as remembered; skip if near next dose.

🔄 Substitutes for cataderm g cream

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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