Butim 250mg Injection (Dobutamine): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe chest pain or pressure
- Rapid or irregular heartbeat
- Difficulty breathing or shortness of breath
- Sudden drop in blood pressure
- Signs of allergic reaction (rash, swelling, difficulty breathing)
- Decreased urine output
- Cold, clammy skin
If experiencing severe symptoms, call emergency services immediately.
What is cardigen injection used for?
This medicine is a dobutamine injection used to treat acute heart failure and cardiogenic shock by increasing the heart's pumping strength. It is given intravenously in a hospital setting under continuous monitoring.
- Generic Name: Dobutamine
- Manufacturer: Palco Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cardigen injection के बारे में (Hindi Summary)
उपयोग: यह दवा डोबुटामाइन इंजेक्शन है, जिसका उपयोग अस्पताल में तीव्र हृदय विफलता, कार्डियोजेनिक शॉक और हृदय की मांसपेशियों की कमजोरी के इलाज के लिए किया जाता है। यह दिल की धड़कन को मजबूत करती है और शरीर के अंगों तक रक्त का प्रवाह बढ़ाती है। यह दवा केवल डॉक्टर की देखरेख में नस के माध्यम से दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दिल की धड़कन तेज होना, सीने में दर्द, सिरदर्द, मतली, उल्टी और सांस लेने में तकलीफ शामिल हैं। गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, उच्च रक्तचाप, निम्न रक्तचाप और दिल का दौरा शामिल हो सकते हैं। कोई भी गंभीर लक्षण होने पर तुरंत डॉक्टर को सूचित करें।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर की निगरानी में दी जानी चाहिए। इसका उपयोग घर पर स्वयं न करें। इंजेक्शन के दौरान दिल की धड़कन, रक्तचाप और ईसीजी की लगातार निगरानी की जाती है। यदि सीने में दर्द, धड़कन तेज होना या सांस लेने में कठिनाई हो तो तुरंत बताएं।
💊 cardigen injection Uses & Benefits
[{"condition":"Acute decompensated heart failure","description":"This medicine is used to increase cardiac contractility and improve cardiac output in patients with acute heart failure who have low cardiac output and adequate filling pressures.","evidence":"Well-established"},{"condition":"Cardiogenic shock","description":"It is used as a temporary measure to support blood pressure and cardiac output in cardiogenic shock until definitive treatment is available.","evidence":"Well-established"},{"condition":"Low cardiac output after cardiac surgery","description":"This medicine is often used in the postoperative period to improve myocardial performance and maintain adequate organ perfusion.","evidence":"Well-established"},{"condition":"Stress echocardiography","description":"It is used as a pharmacological stress agent to detect myocardial ischemia in patients unable to exercise adequately.","evidence":"Well-established"},{"condition":"Septic shock","description":"This medicine may be used as an adjunct to other vasopressors to increase cardiac output in septic shock with myocardial depression.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Pediatric heart failure","description":"This medicine is sometimes used off-label in children with heart failure or low cardiac output states, but dosing is not well established and requires specialist supervision.","evidence":"Limited"},{"condition":"Beta-blocker overdose","description":"This medicine may be used off-label to counteract the negative inotropic and chronotropic effects of beta-blocker overdose.","evidence":"Limited"}]
Primary treatment for: Acute decompensated heart failure
Also treats: Cardiogenic shock, Low cardiac output syndrome, Septic shock with myocardial depression, Stress echocardiography
📋 Drug Information
| Generic Name(s) | Dobutamine |
| Brand Name | Butim 250mg Injection |
| Manufacturer | Palco Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Sympathomimetics agonist-Inotropes |
| Route of Administration | Intravenous (IV) infusion only. Not for intramuscular or subcutaneous use |
| Storage | Store at 20°C to 25°C (68°F to 77°F). Protect from light. Do not freeze. Store in original carton until use. After dilution, the solution should be used within 24 hours if stored at room temperature or 48 hours if refrigerated. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by directly stimulating beta-1 adrenergic receptors on the myocardium, which leads to increased intracellular cyclic AMP and enhanced calcium availability, resulting in a stronger and slightly faster heart contraction. It also has mild beta-2 and alpha-1 agonist activity, which can cause peripheral vasodilation and mild vasoconstriction, respectively. The overall effect is a significant increase in cardiac output with minimal changes in heart rate and blood pressure at therapeutic doses.
Mechanism Steps
💡 How to Take cardigen injection
Strength: 250 mg per vial (reconstituted for intravenous infusion).
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the patient's clinical condition, hemodynamic response, and other factors. The usual adult dose ranges from 2.5 to 20 mcg/kg/min administered as a continuous intravenous infusion. The infusion rate should be titrated to the desired cardiac output, blood pressure, and heart rate. The maximum recommended dose is 40 mcg/kg/min, but doses above 20 mcg/kg/min are rarely used due to increased risk of adverse effects. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Start with a lower dose and titrate slowly. Monitor cardiac function closely. |
| Renal Impairment | No specific dosage adjustment is established for renal impairment. Use with caution and monitor closely. |
| Hepatic Impairment | No specific dosage adjustment is established for hepatic impairment. Use with caution and monitor closely. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the duration of infusion. Typically, the infusion is titrated to effect and not exceed 40 mcg/kg/min. Continuous infusion for more than 72 hours is not recommended due to tolerance. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cardigen injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Beta-blockers | Major | |
| MAOIs | Major | |
| Tricyclic antidepressants | Major | |
| General anesthetics | Major | |
| Oxytocin | Moderate | |
| Nitrates | Moderate | |
| Diuretics | Moderate | |
| Insulin | Moderate | |
| Caffeine | Minor | |
| Thyroid hormones | Minor |
🚨 Major Interactions
- Beta-blockers (e.g., propranolol, metoprolol)
- Monoamine oxidase inhibitors (MAOIs)
- Tricyclic antidepressants
- General anesthetics (e.g., halothane)
- Oxytocin
⚡ Moderate Interactions
- Nitrates
- Diuretics
- Insulin
🍷 Alcohol Interaction
Alcohol may increase the risk of arrhythmias and hypotension. Avoid alcohol during treatment with this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Idiopathic hypertrophic subaortic stenosis","Severe aortic stenosis","Uncorrected cardiac tamponade","Hypersensitivity to dobutamine or sulfite preservatives","Uncorrected hypovolemia"]
⚠️ Warnings & Precautions
["This medicine should be used only in a monitored setting with continuous cardiac monitoring.","Do not use in patients with uncorrected hypovolemia; correct volume depletion before starting infusion.","Use with caution in patients with atrial fibrillation; may increase ventricular rate.","May precipitate or exacerbate myocardial ischemia in patients with coronary artery disease.","Prolonged use may lead to tolerance and desensitization of beta receptors.","Contains sulfites, which may cause allergic reactions in susceptible individuals.","Do not mix with alkaline solutions or other drugs in the same line unless compatibility is established."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when administered to a nursing woman. Consider temporary discontinuation of breastfeeding during infusion.
💊 Overdose Management
Overdose of this medicine can cause severe tachycardia, hypertension, arrhythmias, and myocardial ischemia. There is no specific antidote. Treatment is supportive and symptomatic. Discontinue the infusion immediately and manage arrhythmias and hemodynamic instability as clinically indicated. Consider the use of a beta-blocker for severe tachycardia or arrhythmias, but use with caution as it may worsen heart failure.
⏰ Missed Dose
This medicine is administered as a continuous intravenous infusion in a hospital setting. Missed doses are not applicable. If an infusion is interrupted, the healthcare provider will determine the appropriate action based on the patient's clinical status.
Additional Safety Advice
This medicine must be administered only by a healthcare professional in a hospital or clinic equipped with continuous cardiac monitoring and resuscitation facilities. Do not self-administer this medicine. Inform your doctor if you have a history of heart rhythm problems, high blood pressure, or asthma. Your heart rate, blood pressure, and ECG will be monitored closely during the infusion. Report any chest pain, palpitations, or difficulty breathing immediately. This medicine should not be mixed with alkaline solutions or other drugs in the same intravenous line unless compatibility is established. Use with caution in patients with atrial fibrillation, as it may increase ventricular rate. Do not use if the solution is discolored or contains particles.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially regarding heart rate and blood pressure. Start with a lower dose and titrate slowly. Monitor for signs of ischemia and arrhythmias.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor. This medicine should be used during pregnancy only if clearly needed. It is not known if it affects fertility.
🏥 Post-Surgery Considerations
This medicine is often used after cardiac surgery to support cardiac output. It requires close monitoring in the ICU. Follow your surgical team's instructions for recovery.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It is unlikely to affect dental procedures, but your dentist should be aware of your cardiac condition.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you will be in a hospital setting and activity will be restricted. After discharge, follow your doctor's advice on gradually increasing physical activity. Avoid strenuous exercise until cleared by your cardiologist.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so it will not affect your work or daily activities directly. After treatment, you may need time to recover. Discuss with your doctor when you can return to work and driving.
🛑 When to Stop This Medicine
This medicine is stopped by your healthcare provider when your hemodynamic status stabilizes or if serious side effects occur. Do not attempt to stop or adjust the infusion yourself.
📅 Long-Term Use Effects
Prolonged use of this medicine (more than 72 hours) can lead to tolerance and desensitization of beta receptors, reducing its effectiveness. It may also increase the risk of arrhythmias and myocardial ischemia. Long-term use is not recommended; it is intended for short-term hemodynamic support.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
An alternative inotrope that works via phosphodiesterase inhibition.
Evidence: Well-establishedAnother catecholamine that can increase cardiac output and blood pressure.
Evidence: Well-establishedDevices like intra-aortic balloon pump or ventricular assist devices for severe cases.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, patients with heart failure should receive appropriate vaccinations (e.g., influenza, pneumococcal) as recommended by their doctor.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Protect from light
❌ DON'T
Do not use if solution is discolored
✅ DO
Keep in original carton
❌ DON'T
Do not store in bathroom
✈️ Traveling with This Medicine
This medicine is administered only in a hospital setting, so travel advice is not applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Inform your doctor before traveling. Do not attempt to administer this medicine outside a hospital.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1-2 minutes after the infusion begins.
A: Yes, you can eat normally unless your doctor advises otherwise. There are no specific food restrictions.
A: No, this medicine is typically used for short-term support in a hospital setting. Your doctor will transition you to other treatments as your condition stabilizes.
🤔 Common Patient Concerns
🔄 Substitutes for cardigen injection
View AllAlternative brands with exact same active ingredient:
-
dotamin 250mg injectionNeon Laboratories Ltd ₹48.14 81.5% CHEAPER
-
inoject 250mg injectionGland Pharma Limited ₹52.73 79.7% CHEAPER
-
dobutam 250mg injectionUnited Biotech Pvt Ltd ₹196.90 24.3% CHEAPER
-
dobutasys 250mg injectionSympar Life Sciences ₹225.00 13.5% CHEAPER
-
dobugen pfv 250mg injectionShree Ganesh Pharmaceuticals ₹250.00 3.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Dobutamine can be taken at home.
Fact: Dobutamine must be administered only in a hospital setting with continuous monitoring. - Myth: Dobutamine is a cure for heart failure.
Fact: Dobutamine is a temporary supportive treatment; it does not cure the underlying heart condition. - Myth: Dobutamine can be used for low blood pressure in all patients.
Fact: Dobutamine is not a first-line treatment for all types of low blood pressure; it is specific for low cardiac output states.
🔄 Alternative Options
Generic Alternatives
- Dobutamine injection
Brand Alternatives
- Butim 250mg injection