dotamin 250mg injection

4.4 (18 reviews)

Dobutamine (250mg)

🏭 Neon Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 23, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 23, 2026

What is dotamin 250mg injection used for?

Butim 250mg Injection (Dobutamine) is used to treat CARDIAC. It contains Dobutamine (250mg), which Stimulates beta-1 adrenergic receptors in the heart, increasing myocardial contr. Always consult your doctor before use. Take as prescribed.

Generic Name: Dobutamine
Manufacturer: Neon Laboratories Ltd
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 dotamin 250mg injection Uses & Benefits

Short-term management of cardiac decompensation due to depressed contractility (e.g., acute heart failure, cardiogenic shock).

Off-label uses: Stress echocardiography (dobutamine stress test).

📋 Drug Information

Generic Name(s)	Dobutamine
Brand Name	Butim 250mg Injection
Manufacturer	Neon Laboratories Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	CARDIAC
Action Class	Sympathomimetics agonist-Inotropes
Route of Administration	Intravenous infusion only.
Storage	Store at 20-25°C; protect from light; do not freeze.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntravenous administration results in complete bioavailability.

DistributionDistributes widely into tissues; volume of distribution approximately 0.2 L/kg.

Protein BindingApproximately 25% bound to plasma proteins.

MetabolismPrimarily metabolized in the liver by catechol-O-methyltransferase (COMT) to inactive metabolites.

Half-LifeApproximately 2 minutes.

ExcretionExcreted mainly in urine as metabolites and unchanged drug.

Bioavailability100% (intravenous).

Onset of Action1-2 minutes after intravenous administration.

Peak Plasma TimeWithin 10 minutes after start of infusion.

Duration of ActionShort duration; effects cease shortly after infusion stops.

How It Works

Stimulates beta-1 adrenergic receptors in the heart, increasing myocardial contractility and stroke volume.

Mechanism Steps

1Dobutamine binds to beta-1 adrenergic receptors on cardiac myocytes.

2Activation of Gs protein stimulates adenylate cyclase.

3Increased cyclic AMP (cAMP) levels activate protein kinase A.

💡 How to Take dotamin 250mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of dotamin 250mg injection

✅ Common Side Effects

Increased heart rate
Increased blood pressure
Ventricular ectopic activity
Nausea
Headache
Angina
Palpitations

🚨 Serious Side Effects

Arrhythmias (e.g., ventricular tachycardia, fibrillation)
Myocardial ischemia
Hypotension
Cardiac arrest

⚠️ Rare Side Effects

Hypersensitivity reactions
Thrombocytopenia
Seizures

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
MAOIs	Major	Increased risk of hypertensive crisis
Linezolid	Major	Increased pressor response
Tricyclic antidepressants	Major	Enhanced cardiovascular effects
Halogenated anesthetics	Major	Increased risk of arrhythmias
Beta-blockers	Major	Reduced inotropic effect; unopposed alpha activity
Digoxin	Moderate	Increased risk of arrhythmias
Diuretics	Moderate	Hypokalemia may increase arrhythmia risk
Insulin	Moderate	May alter glucose levels
Antidiabetic agents	Moderate	May alter glucose levels
Theophylline	Minor	Additive chronotropic effects
Thyroid hormones	Minor	Increased cardiovascular effects

🚨 Major Interactions

MAOIs
Linezolid
Tricyclic antidepressants
Halogenated anesthetics
Beta-blockers

⚡ Moderate Interactions

Digoxin
Diuretics
Insulin
Antidiabetic agents

ℹ️ Minor Interactions

Theophylline
Thyroid hormones

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

Avoid alcohol; may increase cardiovascular side effects.

🛡️ Safety & Warnings

🚫 Contraindications

Idiopathic hypertrophic subaortic stenosis, hypersensitivity to dobutamine or sulfites, uncorrected hypovolemia.

📊 Monitoring Parameters

Heart rate, blood pressure, ECG, cardiac output, urine output, electrolyte levels.

🤱 Lactation Safety

Not recommended; unknown if excreted in breast milk.

💊 Overdose Management

Discontinue infusion; supportive measures; beta-blockers may be used for excessive tachycardia or hypertension.

⏰ Missed Dose

Continuous infusion; do not double dose. Adjust infusion rate as prescribed.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

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🔄 Substitutes for dotamin 250mg injection

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Alternative brands with exact same active ingredient (Dobutamine (250mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Trusted Reviewer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Regular Customer Jul 10, 2026

Effective and reliable. Worked as expected.