Esmolol 100mg Injection: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe hypotension (systolic BP < 90 mmHg)
- Profound bradycardia (heart rate < 50 bpm)
- Signs of heart block (dizziness, syncope, chest pain)
- Difficulty breathing or wheezing
- Swelling of face, lips, or throat
- Chest pain or palpitations
- Decreased urine output
- Confusion or altered mental status
If experiencing severe symptoms, call emergency services immediately.
What is cardesmo 100mg injection used for?
This medicine is an intravenous beta-blocker used in emergencies to rapidly control heart rate and blood pressure. It works within minutes and is given only in monitored hospital settings.
- Generic Name: Esmolol
- Manufacturer: SG Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cardesmo 100mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एस्मोलोल 100mg इंजेक्शन है, जिसका उपयोग अस्पताल में आपातकालीन स्थितियों में दिल की धड़कन और रक्तचाप को तेजी से नियंत्रित करने के लिए किया जाता है। यह मुख्य रूप से सुप्रावेंट्रिकुलर टैचीकार्डिया, एट्रियल फाइब्रिलेशन, और सर्जरी के दौरान या बाद में होने वाली तेज धड़कन और उच्च रक्तचाप के इलाज में इस्तेमाल होती है। यह दवा केवल डॉक्टर या प्रशिक्षित स्वास्थ्यकर्मी द्वारा नस में दी जाती है और इसके प्रभाव की निगरानी के लिए लगातार मॉनिटरिंग आवश्यक है।
साइड इफेक्ट्स: आम दुष्प्रभावों में निम्न रक्तचाप, धीमी हृदय गति, चक्कर आना, मतली, सिरदर्द और इंजेक्शन स्थल पर दर्द या लालिमा शामिल हैं। गंभीर दुष्प्रभावों में गंभीर निम्न रक्तचाप, गंभीर ब्रैडीकार्डिया, हृदय अवरोध, ब्रोंकोस्पाज्म और हृदय विफलता का बिगड़ना शामिल हो सकता है। दुर्लभ दुष्प्रभावों में एनाफिलेक्सिस और एंजियोएडेमा हो सकते हैं।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर की देखरेख में ही दी जानी चाहिए। इसे स्वयं न लगाएं। यदि आपको अस्थमा, हृदय विफलता, हृदय अवरोध या निम्न रक्तचाप की समस्या है तो डॉक्टर को बताएं। दवा बंद करने से पहले डॉक्टर से सलाह लें क्योंकि अचानक बंद करने से धड़कन और रक्तचाप फिर से बढ़ सकते हैं।
💊 cardesmo 100mg injection Uses & Benefits
[{"condition":"Supraventricular tachycardia (SVT)","description":"Used for rapid conversion of SVT to normal sinus rhythm or to control ventricular rate.","evidence":"Well-established"},{"condition":"Atrial fibrillation or flutter with rapid ventricular response","description":"Controls heart rate in acute settings when rapid rate control is needed.","evidence":"Well-established"},{"condition":"Intraoperative and postoperative tachycardia and hypertension","description":"Used to manage acute increases in heart rate and blood pressure during and after surgery.","evidence":"Well-established"},{"condition":"Thyroid storm","description":"Adjunctively used to control heart rate and reduce sympathetic symptoms.","evidence":"Limited"},{"condition":"Acute myocardial infarction with tachyarrhythmia","description":"May be used to control heart rate in selected patients with acute coronary syndrome.","evidence":"Limited"}]
Off-label uses: [{"condition":"Adjunct to control of heart rate in septic shock","description":"Sometimes used off-label to manage tachycardia in septic shock after adequate fluid resuscitation.","evidence":"Limited"},{"condition":"Prevention of postoperative atrial fibrillation","description":"May be used off-label in some cardiac surgery patients.","evidence":"Limited"}]
Primary treatment for: Supraventricular tachycardia
Also treats: Atrial fibrillation, Atrial flutter, Intraoperative tachycardia, Postoperative hypertension, Thyroid storm
📋 Drug Information
| Generic Name(s) | Esmolol |
| Brand Name | Cardesmo |
| Manufacturer | SG Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Beta blocker- Cardioselective |
| Route of Administration | Intravenous (IV) infusion only. Not for intramuscular or subcutaneous administration |
| Storage | Store at 20°C to 25°C (68°F to 77°F). Do not freeze. Protect from light. Keep vial in carton until ready to use. After dilution, the solution should be used within 24 hours if stored at room temperature or 48 hours if refrigerated at 2°C to 8°C. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Esmolol is a cardioselective beta-1 adrenergic receptor blocker. It competitively inhibits the binding of catecholamines (epinephrine and norepinephrine) to beta-1 receptors primarily located in the heart. This blockade reduces heart rate, myocardial contractility, and cardiac output, leading to decreased myocardial oxygen demand and blood pressure. At higher doses, it may also block beta-2 receptors in the bronchi and blood vessels, but its selectivity for beta-1 is dose-dependent.
Mechanism Steps
💡 How to Take cardesmo 100mg injection
Strength: Each vial contains Esmolol hydrochloride equivalent to 100mg of esmolol in a sterile, non-pyrogenic solution for intravenous use.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the patient's condition, response, and other factors. For supraventricular tachycardia, a typical regimen is a loading dose of 500 mcg/kg administered over 1 minute, followed by a maintenance infusion of 50 mcg/kg/min for 4 minutes. If response is inadequate, a second loading dose may be given, and the maintenance infusion increased to 100 mcg/kg/min, then up to 200 mcg/kg/min as needed. For intraoperative and postoperative tachycardia and hypertension, a loading dose of 80 mg (or 1 mg/kg) over 30 seconds may be given, followed by an infusion of 150 mcg/kg/min, titrated to effect. Continuous monitoring is mandatory. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of esmolol, particularly bradycardia and hypotension. Doses should be titrated carefully, starting at the lower end of the recommended range. Monitor closely for adverse effects. |
| Renal Impairment | No dosage adjustment is typically required for renal impairment, as esmolol is metabolized by red blood cell esterases. However, the acid metabolite is renally excreted, and in severe renal impairment, it may accumulate. Monitor for adverse effects and adjust infusion rate as needed. |
| Hepatic Impairment | No dosage adjustment is required for hepatic impairment, as esmolol is not metabolized by the liver. However, monitor for any signs of toxicity. |
| Maximum Daily Dose | The maximum recommended maintenance infusion rate is 200 mcg/kg/min. Higher doses may be used in some clinical situations but increase the risk of adverse effects. The total daily dose depends on the duration of infusion and patient weight. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cardesmo 100mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Verapamil | Major | |
| Diltiazem | Major | |
| Digoxin | Major | |
| Clonidine | Major | |
| Reserpine | Major | |
| NSAIDs | Moderate | |
| Insulin | Moderate | |
| Oral hypoglycemics | Moderate | |
| Thyroid hormones | Moderate | |
| Cimetidine | Minor |
🚨 Major Interactions
- Calcium channel blockers (verapamil, diltiazem)
- Digoxin
- Clonidine
- Reserpine
⚡ Moderate Interactions
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Insulin and oral hypoglycemic agents
- Thyroid hormones
🍷 Alcohol Interaction
Alcohol may enhance the hypotensive and sedative effects of esmolol. Patients should avoid alcohol during treatment as it may worsen dizziness and low blood pressure.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe bradycardia","Second- or third-degree heart block","Cardiogenic shock","Decompensated heart failure","Known hypersensitivity to esmolol or any component of the formulation","Severe bronchospastic disease (relative contraindication)"]
⚠️ Warnings & Precautions
["Administer only in a monitored setting with resuscitation equipment available.","Avoid abrupt discontinuation; taper gradually to prevent rebound tachycardia and hypertension.","Use with caution in patients with asthma or bronchospastic disease; beta-1 selectivity is dose-dependent.","May mask symptoms of hypoglycemia in diabetic patients.","May mask signs of hyperthyroidism.","Use with caution in patients with renal impairment; metabolite may accumulate.","Not recommended for use in children; safety and efficacy not established.","Pregnancy Category C; use only if benefit outweighs risk.","Caution in patients with peripheral vascular disease; may worsen symptoms.","Extravasation may cause local tissue necrosis; monitor infusion site."]
🤱 Lactation Safety
It is not known whether esmolol is excreted in human breast milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
Overdose may result in severe hypotension, bradycardia, heart block, and cardiac arrest. Treatment is supportive and symptomatic. Discontinue infusion immediately. Administer intravenous fluids, vasopressors (e.g., dopamine, norepinephrine) for hypotension, and atropine or transcutaneous pacing for bradycardia. Glucagon may be considered for refractory bradycardia. Monitor vital signs and cardiac rhythm until stable.
⏰ Missed Dose
This medicine is administered as a continuous intravenous infusion in a hospital setting. Missed doses are not applicable as the infusion is controlled by healthcare professionals. If an infusion is interrupted, notify the medical staff immediately.
Additional Safety Advice
This medicine must be administered only by a qualified healthcare professional in a setting equipped with continuous cardiac monitoring, blood pressure monitoring, and resuscitation facilities. Do not attempt to self-administer. Inform your doctor if you have a history of asthma, heart failure, heart block, or low blood pressure. Avoid abrupt discontinuation; the infusion should be tapered gradually under medical supervision to prevent rebound tachycardia or hypertension. Report any chest pain, difficulty breathing, or severe dizziness immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially bradycardia and hypotension. Doses should be titrated carefully, starting at the lower end of the recommended range. Close monitoring is essential.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor about the risks and benefits of using this medicine. It is classified as Pregnancy Category C and should be used during pregnancy only if clearly needed.
🏥 Post-Surgery Considerations
This medicine is often used during and after surgery to control heart rate and blood pressure. After surgery, your healthcare team will monitor your vital signs and adjust the infusion as needed. Once stable, you may be transitioned to oral medications.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. Dental procedures may need to be postponed until you are stable. If you are on oral beta-blockers after discharge, your dentist should be aware to avoid interactions with local anesthetics containing epinephrine.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, patients are typically bedridden and monitored. After stabilization, gradual resumption of physical activity is recommended under medical guidance. Avoid strenuous exercise until cleared by your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is used in acute care settings, so it does not directly impact daily work life. After discharge, patients may need to take oral medications and may experience fatigue or dizziness. It is advisable to avoid driving or operating heavy machinery until you feel fully recovered and are cleared by your doctor.
🛑 When to Stop This Medicine
This medicine is stopped by healthcare professionals when the patient's condition stabilizes or when adverse effects occur. It should not be stopped abruptly without medical supervision. If you are discharged on oral medications, follow your doctor's instructions for tapering or discontinuing any beta-blocker therapy.
📅 Long-Term Use Effects
This medicine is intended for short-term use in acute settings. Long-term effects are not well studied because it is not used chronically. Prolonged infusions may increase the risk of hypotension, bradycardia, and heart failure. Monitoring is required throughout the infusion. Once the acute condition is stabilized, patients are typically transitioned to oral medications.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For long-term management after acute stabilization.
Evidence: Well-establishedAlternative for rate control in patients who cannot tolerate beta-blockers.
Evidence: Well-establishedCurative option for certain arrhythmias.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about your current medications.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Protect from light
❌ DON'T
Do not use if solution is discolored or contains particles
✅ DO
Keep in original carton until use
❌ DON'T
Do not store in bathroom
✈️ Traveling with This Medicine
This medicine is administered in a hospital setting and is not for outpatient use. If you are traveling and have a prescription for this medicine, carry it in its original packaging with a copy of the prescription. Store it at room temperature, away from direct sunlight. Inform security personnel at airports that you are carrying a prescribed injectable medication. Since this medicine is given intravenously under medical supervision, travel-related dose adjustments are not applicable.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1-2 minutes after the infusion begins.
A: The effects last for about 10-20 minutes after the infusion is stopped.
A: No, this medicine must be given in a hospital or clinic setting with continuous monitoring.
A: It is classified as Pregnancy Category C. It should be used only if the potential benefit justifies the potential risk to the fetus.
A: Common side effects include low blood pressure, slow heart rate, dizziness, nausea, and headache.
🤔 Common Patient Concerns
🔄 Substitutes for cardesmo 100mg injection
View AllAlternative brands with exact same active ingredient:
-
miniblock 100mg injectionUSV Ltd ₹45.00 75% CHEAPER
-
esmocard 100mg injectionTroikaa Pharmaceuticals Ltd ₹227.81 26.6% COSTLIER
-
esocard 100mg injectionSamarth Life Sciences Pvt Ltd ₹276.90 53.8% COSTLIER
-
neotach 100mg injectionNeon Laboratories Ltd ₹276.90 53.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is for intravenous use only and must be given by a healthcare professional. - Myth: This medicine is safe for self-administration.
Fact: This medicine requires continuous monitoring and should only be administered in a hospital setting. - Myth: This medicine can be stopped abruptly without any risk.
Fact: Abrupt discontinuation can cause rebound tachycardia and hypertension; it must be tapered gradually.
🔄 Alternative Options
Generic Alternatives
- Esmolol hydrochloride injection
Brand Alternatives
- Cardesmo 100mg injection