captabin 500mg tablet

4.3 (14 reviews)

Capecitabine (500mg)

🏭 Shantha Biotech 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is captabin 500mg tablet used for?

bdocin 500mg capsule (Capecitabine) is used to treat ANTI NEOPLASTICS. It contains Capecitabine (500mg), which Prodrug converted to 5-FU, which inhibits thymidylate synthase and incorporates . Always consult your doctor before use. Take as prescribed.

Generic Name: Capecitabine
Manufacturer: Shantha Biotech
Form: Allopathy
Pregnancy Category: D
Prescription Required: Yes

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 captabin 500mg tablet Uses & Benefits

Colorectal cancer, breast cancer, gastric cancer, esophageal cancer

Off-label uses: Pancreatic cancer, hepatocellular carcinoma

📋 Drug Information

Generic Name(s)	Capecitabine
Brand Name	bdocin 500mg capsule
Manufacturer	Shantha Biotech
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Antimetabolites
Route of Administration	Oral
Storage	Store at 20-25°C (68-77°F); protect from moisture
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed orally; prodrug converted to 5-FU

DistributionDistributes widely into tissues including tumors

Protein BindingApproximately 54% bound to plasma proteins

MetabolismHepatic and tissue metabolism via carboxylesterase, cytidine deaminase, and thymidine phosphorylase to 5-FU

Half-Life0.75-1 hour (capecitabine); 0.5-1 hour (5-FU)

ExcretionRenal (95.5% as metabolites, 2.9% as parent drug)

BioavailabilityApproximately 100%

Onset of ActionRapid; within hours

Peak Plasma Time1.5-2 hours

Duration of ActionVariable; depends on schedule

How It Works

Prodrug converted to 5-FU, which inhibits thymidylate synthase and incorporates into RNA/DNA

Mechanism Steps

1Capecitabine is absorbed orally and converted to 5'-deoxy-5-fluorocytidine (5'-DFCR) by carboxylesterase in the liver

25'-DFCR is converted to 5'-deoxy-5-fluorouridine (5'-DFUR) by cytidine deaminase in liver and tumor tissues

35'-DFUR is converted to 5-fluorouracil (5-FU) by thymidine phosphorylase, which is higher in tumor cells

💡 How to Take captabin 500mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of captabin 500mg tablet

✅ Common Side Effects

Diarrhea
Hand-foot syndrome
Nausea
Vomiting
Fatigue
Anorexia
Abdominal pain
Stomatitis

🚨 Serious Side Effects

Myelosuppression
Severe diarrhea
Cardiotoxicity
Hepatotoxicity
Neurotoxicity
Dehydration

⚠️ Rare Side Effects

Encephalopathy
Cerebellar ataxia
Keratitis
Lacrimal duct stenosis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased INR and bleeding risk
Phenytoin	Major	Increased phenytoin levels
Leucovorin	Major	Increased toxicity of 5-FU
Sorivudine	Major	Fatal toxicity due to DPD inhibition
Brivudine	Major	Fatal toxicity due to DPD inhibition
Allopurinol	Moderate	Decreased efficacy of capecitabine
Metronidazole	Moderate	Increased 5-FU toxicity
Cimetidine	Moderate	Increased capecitabine levels
Folic acid	Moderate	Increased toxicity
Antacids	Minor	Decreased absorption
Ranitidine	Minor	Decreased absorption

🚨 Major Interactions

Warfarin
Phenytoin
Leucovorin
Sorivudine
Brivudine

⚡ Moderate Interactions

Allopurinol
Metronidazole
Cimetidine
Folic acid

ℹ️ Minor Interactions

Antacids
Ranitidine

🍽️ Food Interactions

Food reduces rate and extent of absorption; take with food or within 30 min after meal

🍷 Alcohol Interaction

Avoid alcohol; may increase hepatotoxicity risk

🛡️ Safety & Warnings

🚫 Contraindications

Severe renal impairment (CrCl <30 mL/min), DPD deficiency, hypersensitivity, pregnancy, lactation

📊 Monitoring Parameters

CBC, LFTs, renal function, INR (if on warfarin), DPD deficiency screening

🤱 Lactation Safety

Contraindicated; excreted in milk

💊 Overdose Management

Supportive care; no specific antidote; monitor for myelosuppression, GI toxicity

⏰ Missed Dose

Do not double dose; skip missed dose and continue regular schedule

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for captabin 500mg tablet

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Alternative brands with exact same active ingredient (Capecitabine (500mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Certified Buyer Jul 10, 2026

Effective and reliable. Worked as expected.

Regular Customer Jul 10, 2026

Found this to be a helpful product. Good results.

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.