candicef cream - Uses, Price, Side Effects & Substitutes
What is candicef cream used for?
Avoderm Plus Cream (Terbinafine + Clobetasol) is used to treat DERMA. It contains Terbinafine (1% w/w) + Clobetasol (0.05% w/w), which Terbinafine inhibits squalene epoxidase, disrupting ergosterol synthesis; Clobet. Always consult your doctor before use. Take as prescribed.
- Generic Name: Terbinafine + Clobetasol
- Manufacturer: Iceberg Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ candicef cream Uses & Benefits
Tinea pedis, tinea cruris, tinea corporis with inflammatory symptoms.
Off-label uses: Seborrheic dermatitis, Psoriasis
๐ Drug Information
| Generic Name(s) | Terbinafine + Clobetasol |
| Brand Name | Avoderm Plus Cream |
| Manufacturer | Iceberg Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | DERMA |
| Action Class | Antifungal + Corticosteroid |
| Route of Administration | Topical |
| Storage | Store at 20-25ยฐC (68-77ยฐF); keep tightly closed. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Terbinafine inhibits squalene epoxidase, disrupting ergosterol synthesis; Clobetasol binds to glucocorticoid receptors, suppressing inflammation.
Mechanism Steps
๐ก How to Take candicef cream
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of candicef cream
โ Common Side Effects
- Application site irritation
- Pruritus
- Burning
๐จ Serious Side Effects
- Skin atrophy
- Hypothalamic-pituitary-adrenal axis suppression
- Allergic contact dermatitis
โ ๏ธ Rare Side Effects
- Hypertrichosis
- Perioral dermatitis
- Acneiform eruptions
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| CYP3A4 inhibitors | Major | Increased systemic exposure of clobetasol |
| CYP3A4 inducers | Major | Decreased efficacy of clobetasol |
| Warfarin | Moderate | Potential increased INR |
| Cyclosporine | Moderate | Increased risk of nephrotoxicity |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP3A4 inducers (e.g., rifampin)
โก Moderate Interactions
- Warfarin
- Cyclosporine
โน๏ธ Minor Interactions
- Antacids
- Cimetidine
๐ฝ๏ธ Food Interactions
No significant food interactions for topical use.
๐ท Alcohol Interaction
No known interaction.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to any component; viral skin infections (e.g., herpes); fungal nail infections (monotherapy).
๐ Monitoring Parameters
Skin improvement; signs of skin atrophy or systemic effects with prolonged use.
๐คฑ Lactation Safety
Use with caution; avoid application to breast area.
๐ Overdose Management
Unlikely with topical use; if ingested, symptomatic treatment.
โฐ Missed Dose
Apply as soon as remembered; skip if almost time for next dose.