canazole-b lotion - Beclometasone (0.025% w/v) + Clotrimazole (1% w/v) medicine

canazole-b lotion - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Lupin Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 29, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 29, 2026

What is canazole-b lotion used for?

Beclo C Lotion (Beclometasone + Clotrimazole) is used to treat DERMA. It contains Beclometasone (0.025% w/v) + Clotrimazole (1% w/v), which Beclometasone reduces inflammation by suppressing cytokines and immune response;. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Beclometasone + Clotrimazole
  • Manufacturer: Lupin Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š canazole-b lotion Uses & Benefits

Treatment of inflammatory dermatoses with secondary fungal infections, e.g., eczema with candidiasis.

Off-label uses: Seborrheic dermatitis, Intertrigo

๐Ÿ“‹ Drug Information

Generic Name(s)Beclometasone + Clotrimazole
Brand NameBeclo C Lotion
ManufacturerLupin Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassCorticosteroid + Antifungal
Route of AdministrationTopical
StorageStore at room temperature (15-30ยฐC); keep tightly closed.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionTopical absorption is minimal; systemic absorption may occur with prolonged use on large areas or damaged skin.
DistributionDistributes locally in skin layers; systemic distribution limited.
Protein BindingBeclometasone: ~87% bound to plasma proteins; Clotrimazole: ~90% bound.
MetabolismBeclometasone: Hepatic via CYP3A4; Clotrimazole: Hepatic to inactive metabolites.
Half-LifeBeclometasone: ~6.5 hours; Clotrimazole: ~3-6 hours.
ExcretionBeclometasone: Urine and feces; Clotrimazole: Feces (biliary) and urine.
BioavailabilityLow systemic bioavailability due to topical application.
Onset of ActionWithin a few days of regular application.
Peak Plasma TimeNot applicable for topical use; systemic levels minimal.
Duration of ActionDepends on frequency of application; typically 12-24 hours.

How It Works

Beclometasone reduces inflammation by suppressing cytokines and immune response; Clotrimazole inhibits fungal ergosterol synthesis, disrupting cell membrane.

Mechanism Steps

1Beclometasone binds to glucocorticoid receptors in skin cells.
2Receptor complex translocates to nucleus, modulating gene transcription.
3Decreases production of pro-inflammatory cytokines (e.g., IL-1, TNF-ฮฑ).

๐Ÿ’ก How to Take canazole-b lotion

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of canazole-b lotion

โœ… Common Side Effects

  • Burning
  • itching
  • irritation
  • dryness

๐Ÿšจ Serious Side Effects

  • Skin atrophy
  • telangiectasia
  • adrenal suppression
  • allergic contact dermatitis

โš ๏ธ Rare Side Effects

  • Hypertrichosis
  • perioral dermatitis
  • hypopigmentation

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
CYP3A4 inhibitors (e.g., ketoconazole) Major Increased systemic beclometasone exposure
CYP3A4 inducers (e.g., rifampin) Major Decreased beclometasone efficacy
Warfarin Moderate Possible enhanced anticoagulant effect
Insulin Moderate May increase blood glucose levels

๐Ÿšจ Major Interactions

  • CYP3A4 inhibitors
  • CYP3A4 inducers

โšก Moderate Interactions

  • Anticoagulants
  • Antidiabetic agents

โ„น๏ธ Minor Interactions

  • Topical corticosteroids
  • Other antifungals

๐Ÿท Alcohol Interaction

No known interaction.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to components, untreated bacterial or viral skin infections, fungal infections not responsive to clotrimazole.

๐Ÿ“Š Monitoring Parameters

Skin condition, signs of systemic absorption (e.g., adrenal suppression) with prolonged use.

๐Ÿคฑ Lactation Safety

Use with caution; avoid application to breast area.

๐Ÿ’Š Overdose Management

Topical overdose unlikely; if ingested, symptomatic treatment.

โฐ Missed Dose

Apply as soon as remembered; skip if almost time for next dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 29, 2026

๐Ÿ”— View Profile

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