cafimol tablet - Paracetamol (500mg) + Caffeine (20mg) medicine

Cafimol Tablet: Complete Medicine Guide

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🏭 Medirose drug & pharma 📦 Varies by brand 💊 Allopathy 📅 Updated: Nov 11, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for paracetamol; caffeine as adjuvant has good evidence.
Dr. Ravishankar Kumar
Medically Reviewed by Dr. Ravishankar Kumar ✓ Verified Doctor
B.A.M.S. (RMLAU Ayodhya) • Ex-Balrampur Hospital, Lucknow
Dr. Ravishankar Kumar
Clinically Verified by Dr. Ravishankar Kumar (B.A.M.S., RMLAU) — View Medical Verification Profile ↗
Clinical Background: Balrampur Hospital, Lucknow (Emergency Medicine) & SCPM Hospital | Standards: CDSCO, Indian Pharmacopoeia (IP) & WHO

When to Call Your Doctor IMMEDIATELY

  • Yellowing of skin or eyes (jaundice)
  • Severe abdominal pain
  • Blood in vomit or stool
  • Difficulty breathing or swelling of face, lips, or throat
  • Unusual bleeding or bruising
  • Decreased urine output
  • Persistent high fever

If experiencing severe symptoms, call emergency services immediately.

What is cafimol tablet used for?

This medicine is a combination of Paracetamol 500 mg and Caffeine 20 mg used for relief of mild to moderate pain and fever. It works by reducing pain and fever, with caffeine enhancing the analgesic effect.

  • Generic Name: Paracetamol + Caffeine
  • Manufacturer: Medirose drug & pharma
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 cafimol tablet के बारे में (Hindi Summary)

उपयोग: यह दवा पैरासिटामोल और कैफीन का संयोजन है, जिसका उपयोग हल्के से मध्यम दर्द और बुखार के इलाज के लिए किया जाता है। यह सिरदर्द, माइग्रेन, दांत दर्द, मासिक धर्म में होने वाले दर्द, मांसपेशियों में दर्द और सर्दी-जुकाम से जुड़े दर्द में राहत देती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, पेट में परेशानी, बेचैनी और अनिद्रा शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन जिगर की क्षति या एलर्जी प्रतिक्रिया हो सकती है। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। शराब का सेवन न करें। अन्य पैरासिटामोल युक्त दवाओं के साथ न लें। यदि दर्द 5 दिन से अधिक या बुखार 3 दिन से अधिक रहे तो डॉक्टर से मिलें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

cafimol tablet Uses & Benefits

Headache Well-established

Relieves mild to moderate headache pain, including tension headaches.

Migraine Well-established

Helps alleviate migraine pain; caffeine may enhance the effect of paracetamol.

Toothache Well-established

Provides temporary relief from dental pain.

Menstrual cramps Well-established

Reduces pain associated with menstruation.

Muscle aches Well-established

Relieves minor muscle pain and soreness.

Fever Well-established

Reduces fever due to its paracetamol content.

Off-Label & Investigational Uses:

Post-operative pain Limited (Off-label)

Sometimes used as part of multimodal analgesia, but not a primary indication.

Osteoarthritis pain Limited (Off-label)

May be used for short-term relief, but not first-line.

Primary Treatment for: Pain and fever
Also Treats:
Headache Migraine Toothache Menstrual cramps Muscle aches

📋 Drug Information

Generic Name(s)Paracetamol + Caffeine
Brand NameAlergin Cold Total Tablet
ManufacturerMedirose drug & pharma
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAnalgesic Antipyretic Combination
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Avoid alcohol while taking this medicine to prevent liver damage.
3
Do not exceed the recommended dose; maximum 8 tablets in 24 hours.
4
Do not take other paracetamol-containing products concurrently.
5
Consult your doctor if pain persists beyond 5 days or fever beyond 3 days.
6
Be aware that caffeine may cause insomnia; avoid taking close to bedtime.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Headache
This medicine is commonly used for headache relief.
Likely Use
✅
Fever
This medicine helps reduce fever.
Likely Use
❌
Chronic joint pain
This medicine is not a primary treatment for chronic joint pain.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionParacetamol is rapidly and almost completely absorbed from the gastrointestinal tract after oral administration. Caffeine is also rapidly absorbed. Peak plasma concentrations of paracetamol occur within 30-60 minutes; caffeine peaks within 30-60 minutes.
DistributionParacetamol is distributed widely throughout most body tissues, with a volume of distribution of about 0.9 L/kg. It crosses the placenta and is excreted in breast milk. Caffeine is distributed throughout body fluids and crosses the blood-brain barrier and placenta.
Protein BindingParacetamol: approximately 10-25% bound to plasma proteins. Caffeine: approximately 10-35% bound to plasma proteins.
MetabolismParacetamol is metabolized primarily in the liver via glucuronidation and sulfation, with a small fraction metabolized by CYP2E1 to a toxic intermediate (NAPQI) that is detoxified by glutathione. Caffeine is metabolized in the liver by CYP1A2 to paraxanthine, theobromine, and theophylline.
Half-LifeParacetamol: 2-3 hours; Caffeine: 3-5 hours.
ExcretionParacetamol metabolites are excreted primarily in the urine. Caffeine metabolites are excreted in urine.
BioavailabilityParacetamol: approximately 80-100% after oral administration. Caffeine: approximately 99% after oral administration.
Onset of ActionPain relief typically begins within 30-60 minutes after oral administration.
Peak Plasma TimeParacetamol: 30-60 minutes; Caffeine: 30-60 minutes.
Duration of ActionPain relief lasts approximately 4-6 hours.

How It Works

Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis, which reduces pain and fever. It also modulates the endogenous opioid system and serotonin pathways. Caffeine is an adenosine receptor antagonist that increases alertness and may enhance the analgesic effect of paracetamol by constricting cerebral blood vessels and improving the penetration of paracetamol into the brain.

Mechanism Steps

1
Paracetamol inhibits prostaglandin synthesis: Paracetamol reduces the production of prostaglandins in the central nervous system, which are involved in pain and fever.
2
Caffeine blocks adenosine receptors: Caffeine antagonizes adenosine A1 and A2A receptors, leading to increased neuronal activity and release of neurotransmitters.
3
Enhanced analgesia: Caffeine potentiates the analgesic effect of paracetamol by increasing its bioavailability in the brain and modulating pain pathways.

💡 How to Take cafimol tablet

Strength: Tablet: Paracetamol 500 mg + Caffeine 20 mg

1Take this medicine orally with a glass of water.
2Swallow the tablet whole; do not crush or chew.
3Take with food to reduce stomach upset.
4Follow the prescribed dose and frequency.
5Do not exceed the maximum daily dose.

Dosage Information

Adult DosageThe usual adult dose is 1-2 tablets every 4-6 hours as needed for pain or fever, not to exceed 8 tablets in 24 hours. However, the dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the maximum daily dose of 4000 mg of paracetamol.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of caffeine and paracetamol. Use with caution and consult a doctor for appropriate dosing.
Renal ImpairmentIn patients with severe renal impairment, dose reduction or longer dosing intervals may be necessary. Consult a doctor.
Hepatic ImpairmentIn patients with hepatic impairment, dose reduction or avoidance is recommended. Consult a doctor.
Maximum Daily DoseMaximum 8 tablets in 24 hours (4000 mg paracetamol). Do not exceed.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase caffeine levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of cafimol tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food to reduce nausea. If persistent, consult your doctor.
Insomnia (Common (5-10%))
Avoid taking close to bedtime. If it persists, consult your doctor.
Restlessness (Common (5-10%))
Usually temporary. If bothersome, consult your doctor.
Stomach discomfort (Common (5-10%))
Take with food or milk to minimize discomfort.

🚨 Serious Side Effects

Severe skin reactions (e.g., Stevens-Johnson syndrome) (Rare (<0.1%))
Seek immediate medical attention if you develop rash, blisters, or peeling skin.
Liver damage (Rare (<0.1%) with recommended doses; higher with overdose)
Seek immediate medical attention if you experience yellowing of eyes or skin, dark urine, or severe abdominal pain.
Allergic reactions (anaphylaxis) (Rare (<0.1%))
Seek emergency help if you have difficulty breathing, swelling of face, lips, or throat.

⚠️ Rare Side Effects

Blood disorders (e.g., thrombocytopenia)
Consult doctor if you notice unusual bleeding or bruising.
Pancreatitis
Seek medical attention if you have severe abdominal pain.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Alcohol Major
Carbamazepine Moderate
Fluconazole Moderate
Cimetidine Moderate
Oral contraceptives Minor
Ciprofloxacin Minor
Phenytoin Moderate
Rifampicin Moderate
Ketoconazole Moderate

🚨 Major Interactions

  • Warfarin
  • Alcohol
  • Other paracetamol-containing products

⚡ Moderate Interactions

  • Carbamazepine, phenytoin, rifampicin
  • Fluconazole, ketoconazole
  • Cimetidine

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage from paracetamol and may worsen side effects like dizziness and drowsiness.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to paracetamol or caffeine","Severe liver disease","Severe kidney disease","Regular heavy alcohol consumption"]

⚠️ Warnings & Precautions

["Do not exceed the recommended dose.","Avoid alcohol while taking this medicine.","Do not use with other paracetamol-containing products.","Use with caution in patients with liver or kidney disease.","Consult doctor if pain persists beyond 5 days or fever beyond 3 days.","May cause insomnia; avoid taking close to bedtime.","Not recommended for children under 12 years without medical advice."]

🤱 Lactation Safety

Paracetamol and caffeine are excreted in breast milk in small amounts. Generally considered compatible with breastfeeding, but consult your doctor.

💊 Overdose Management

Overdose can cause severe liver damage. Symptoms may include nausea, vomiting, abdominal pain, and confusion. Seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine, and supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Always take this medicine exactly as directed by your doctor or as per the label. Do not exceed the recommended dose or duration of use. Avoid consuming alcohol while taking this medicine as it increases the risk of liver damage. Inform your doctor if you have liver or kidney disease, or if you are pregnant or breastfeeding. Do not take other products containing Paracetamol while on this medicine to prevent overdose. Keep out of reach of children. If pain persists for more than 5 days or fever for more than 3 days, consult a doctor.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to caffeine and paracetamol. Use with caution and consult a doctor for appropriate dosing.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. Limit caffeine intake.

🏥 Post-Surgery Considerations

This medicine may be used for post-operative pain under medical supervision. Inform your surgeon if you are taking it.

🦷 Dental Procedures

This medicine can be taken for dental pain. Inform your dentist if you are taking it before any procedure.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints.
🥗
Stay hydrated by drinking plenty of water.
😴
Get adequate sleep to help manage pain.
💧
Practice relaxation techniques to reduce tension headaches.
🧘
Limit caffeine intake from other sources to avoid insomnia.

🏋️ Exercise Considerations

Moderate exercise is generally safe while taking this medicine. However, if you experience dizziness or palpitations, avoid strenuous activities and consult your doctor.

🥗 Diet Recommendations

Include omega-3 rich foods like fish to reduce inflammation.
Avoid excessive caffeine from coffee, tea, and energy drinks.
Eat a balanced diet to support overall health.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or restlessness in some individuals. Avoid driving or operating heavy machinery if you feel drowsy or unsteady.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your pain or fever persists beyond the recommended duration, or if you experience any severe side effects.

📅 Long-Term Use Effects

Long-term use of this medicine at high doses can lead to liver damage and kidney problems. Regular monitoring of liver and kidney function may be required if used for prolonged periods. It is not recommended for chronic use without medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can help manage chronic pain conditions.

Evidence: Well-established
Relaxation techniques

May reduce tension headaches.

Evidence: Some evidence

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No known interactions with vaccines. However, if you have a fever, consult your doctor before vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of the prescription. Store at room temperature and protect from direct sunlight. When traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying medications.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with tension headaches
She started taking this medicine as needed for her headaches. She found that taking it with a meal reduced her stomach discomfort. She was advised not to exceed the recommended dose and to avoid alcohol. Her headaches improved significantly.
💡 Lesson: Taking this medicine with food and adhering to the dose ensures safety and efficacy.
👤 A 50-year-old man with occasional migraines
He used this medicine at the onset of migraine. The caffeine content helped him feel more alert and reduced his migraine pain. He was cautioned about limiting caffeine intake from other sources to avoid insomnia.
💡 Lesson: Caffeine in this medicine can enhance pain relief but monitor total caffeine intake.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30-60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best to take it with food to reduce stomach upset.

Q: Is it safe during pregnancy?

A: Paracetamol is generally considered safe, but caffeine should be limited. Consult your doctor before use.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my liver?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🛑 Myths vs. Facts

  • Myth: Cafimol tablet is safe for everyone.
    Fact: It is not safe for individuals with severe liver disease or those who consume alcohol regularly.
  • Myth: You can take cafimol tablet on an empty stomach.
    Fact: It is better to take it with food to reduce stomach upset.

🔄 Alternative Options

Generic Alternatives

  • Paracetamol + Caffeine tablets

Brand Alternatives

  • Cafimol Tablet

📊 Comparison with Similar Medicines

MedicineCompositionUsesNotes
Cafimol TabletParacetamol 500 mg + Caffeine 20 mgPain and feverCaffeine enhances analgesia
Paracetamol 500 mgParacetamol 500 mgPain and feverNo caffeine
Ibuprofen 400 mgIbuprofen 400 mgPain, fever, inflammationNSAID; different side effect profile

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