bye-cold oral suspension - Chlorpheniramine Maleate (1mg/5ml) + Paracetamol (125mg/5ml) medicine

Bye-Cold Oral Suspension - Uses, Price, Side Effects

4.5 (16 reviews)
๐Ÿญ Bendic Healthcare Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 24, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 24, 2026

What is bye-cold oral suspension used for?

Bye-Cold Oral Suspension is a combination medicine used to relieve symptoms of the common cold and flu, such as runny nose, sneezing, nasal congestion, fever, and body aches. It contains Chlorpheniramine Maleate (an antihistamine that reduces allergy symptoms) and Paracetamol (an analgesic and antipyretic that lowers fever and relieves pain). It is typically taken every 4-6 hours as needed.

  • Generic Name: Chlorpheniramine Maleate + Paracetamol
  • Manufacturer: Bendic Healthcare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š bye-cold oral suspension Uses & Benefits

Allergic rhinitis, common cold, fever, mild pain

Off-label uses: Urticaria, motion sickness (Chlorpheniramine)

๐Ÿ“‹ Drug Information

Generic Name(s)Chlorpheniramine Maleate + Paracetamol
Brand NameAlex P Syrup
ManufacturerBendic Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAntihistamine + Analgesic/Antipyretic
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed from gastrointestinal tract
DistributionWidely distributed throughout body
Protein BindingChlorpheniramine: 70%; Paracetamol: 25%
MetabolismChlorpheniramine: Hepatic via CYP450; Paracetamol: Hepatic via conjugation
Half-LifeChlorpheniramine: 21-27 hours; Paracetamol: 2-3 hours
ExcretionRenal (urine)
BioavailabilityChlorpheniramine: 25-50%; Paracetamol: 85-90%
Onset of ActionChlorpheniramine: 30-60 min; Paracetamol: 30-60 min
Peak Plasma TimeChlorpheniramine: 2-6 hours; Paracetamol: 30-60 min
Duration of ActionChlorpheniramine: 4-6 hours; Paracetamol: 4-6 hours

How It Works

Chlorpheniramine: H1-receptor antagonist; Paracetamol: COX inhibition in CNS

Mechanism Steps

1Chlorpheniramine competitively blocks H1 receptors, preventing histamine-mediated effects
2Paracetamol inhibits COX enzymes in the CNS, reducing prostaglandin synthesis
3Decreased prostaglandin leads to antipyretic and analgesic effects

๐Ÿ’ก How to Take bye-cold oral suspension

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of bye-cold oral suspension

โœ… Common Side Effects

  • Drowsiness
  • Dry mouth
  • Nausea
  • Dizziness

๐Ÿšจ Serious Side Effects

  • Hepatotoxicity
  • Severe allergic reaction
  • Blood dyscrasias

โš ๏ธ Rare Side Effects

  • Thrombocytopenia
  • Agranulocytosis
  • Stevens-Johnson syndrome

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk due to Paracetamol
MAOIs Major Hypertensive crisis due to Chlorpheniramine
Alcohol Moderate Increased liver toxicity risk
CNS Depressants Moderate Enhanced sedation

๐Ÿšจ Major Interactions

  • MAOIs
  • Alcohol
  • CNS depressants

โšก Moderate Interactions

  • Warfarin
  • Isoniazid
  • Rifampin

โ„น๏ธ Minor Interactions

  • Anticholinergics
  • Corticosteroids

๐Ÿฝ๏ธ Food Interactions

Avoid alcohol, No significant food interactions

๐Ÿท Alcohol Interaction

Increased CNS depression and hepatotoxicity risk

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Moderate
Kidney
Low
Heart
Low
Pregnancy
Category A

๐Ÿšซ Contraindications

Hypersensitivity, severe hepatic impairment, MAOI use

๐Ÿ“Š Monitoring Parameters

Liver function tests, renal function, CBC

๐Ÿคฑ Lactation Safety

Use with caution; small amounts excreted in breast milk

๐Ÿ’Š Overdose Management

Activated charcoal, N-acetylcysteine for paracetamol overdose; supportive care

โฐ Missed Dose

Take as soon as remembered; skip if near next dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 24, 2026

๐Ÿ”— View Profile

โญ User Reviews

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Verified User Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Regular Customer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

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