Ampoxin 250 Capsule: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe, persistent diarrhea or abdominal cramps
- Yellowing of the skin or eyes (jaundice)
- Unusual bleeding or bruising
- Decreased urine output or swelling in the legs
- Seizures or confusion
- Severe skin rash with blisters or peeling
If experiencing severe symptoms, call emergency services immediately.
What is broadiclox 125mg/125mg injection used for?
This medicine is a combination antibiotic containing Ampicillin and Cloxacillin. It is used to treat bacterial infections of the skin, respiratory tract, and urinary tract. It works by killing bacteria. Take it exactly as prescribed by your doctor.
- Generic Name: Ampicillin + Cloxacillin
- Manufacturer: Alkem Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 broadiclox 125mg/125mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एम्पीसिलिन और क्लोक्सासिलिन का संयोजन है, जो बैक्टीरियल संक्रमण के इलाज के लिए उपयोग की जाती है। यह त्वचा, श्वसन तंत्र और मूत्र मार्ग के संक्रमण के लिए निर्धारित की जाती है। यह बैक्टीरिया को मारकर काम करती है। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, दस्त और पेट में परेशानी शामिल हैं। कुछ रोगियों में त्वचा पर दाने या खुजली हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर दस्त हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी दवाओं और एलर्जी के बारे में बताएं। इसे डॉक्टर के बताए अनुसार ही लें और पूरा कोर्स पूरा करें। बिना डॉक्टर की सलाह के इसे बंद न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से परामर्श करें। शराब का सेवन न करें।
💊 broadiclox 125mg/125mg injection Uses & Benefits
[{"condition":"Skin and soft tissue infections","description":"Effective against cellulitis, impetigo, and wound infections caused by susceptible gram-positive bacteria, including penicillinase-producing Staphylococcus aureus.","evidence":"Well-established"},{"condition":"Respiratory tract infections","description":"Used for community-acquired pneumonia, acute exacerbations of chronic bronchitis, and sinusitis when caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"May be used for uncomplicated UTIs caused by susceptible strains of Escherichia coli, Proteus mirabilis, and Enterococcus faecalis.","evidence":"Moderate"},{"condition":"Bone and joint infections","description":"Sometimes used for osteomyelitis and septic arthritis caused by susceptible staphylococci and streptococci.","evidence":"Limited"},{"condition":"Dental infections","description":"Prescribed for dental abscesses and pericoronitis caused by susceptible oral flora.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Lyme disease","description":"Ampicillin component may be used off-label for early Lyme disease, but not typically as a combination.","evidence":"Limited"},{"condition":"Helicobacter pylori eradication","description":"Ampicillin is sometimes included in combination regimens for H. pylori, but cloxacillin is not standard.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Skin infections, Respiratory tract infections, Urinary tract infections
📋 Drug Information
| Generic Name(s) | Ampicillin + Cloxacillin |
| Brand Name | Ampoxin 500 Capsule |
| Manufacturer | Alkem Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Penicillinase-resistant penicillin combination |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two penicillin antibiotics that inhibit bacterial cell wall synthesis. Ampicillin binds to penicillin-binding proteins (PBPs) and inhibits the transpeptidation reaction, preventing cross-linking of peptidoglycan chains, leading to bacterial cell lysis. Cloxacillin also binds to PBPs but is resistant to hydrolysis by penicillinase enzymes produced by certain staphylococci, allowing it to effectively kill penicillinase-producing Staphylococcus aureus. The combination provides a broader spectrum of activity than either agent alone.
Mechanism Steps
💡 How to Take broadiclox 125mg/125mg injection
Strength: Capsule containing Ampicillin 125 mg and Cloxacillin 125 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one capsule (Ampicillin 125 mg + Cloxacillin 125 mg) taken orally every 6 hours. However, the exact dose and duration depend on the type and severity of the infection, as well as the patient's age, weight, renal and hepatic function. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function, which may require dose adjustment. Use with caution and monitor renal function. |
| Renal Impairment | In patients with renal impairment, dose adjustment is required based on creatinine clearance. Consult a physician for specific dosing. |
| Hepatic Impairment | In patients with hepatic impairment, dose adjustment may be necessary. Monitor liver function closely. |
| Maximum Daily Dose | The maximum recommended daily dose is not established from available information. Follow your doctor's prescription. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of broadiclox 125mg/125mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Allopurinol | Major | |
| Oral contraceptives | Moderate | |
| Probenecid | Moderate | |
| Tetracyclines | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Allopurinol
⚡ Moderate Interactions
- Oral contraceptives
- Probenecid
- Tetracyclines
🍷 Alcohol Interaction
Alcohol may worsen gastrointestinal side effects such as nausea and diarrhea. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to penicillins or cephalosporins","History of severe allergic reaction to beta-lactam antibiotics","Infectious mononucleosis (increased risk of rash)","Concurrent use with live typhoid vaccine"]
⚠️ Warnings & Precautions
["Serious and occasionally fatal hypersensitivity reactions can occur. Before initiating therapy, inquire about previous hypersensitivity to penicillins, cephalosporins, or other allergens.","Clostridioides difficile-associated diarrhea may occur. If diarrhea develops, evaluate for this condition.","Use with caution in patients with renal impairment. Dose adjustment may be necessary.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi.","This medicine may interfere with laboratory tests, including urinary glucose tests and direct Coombs test.","Not effective against viral infections. Do not use for colds or flu."]
🤱 Lactation Safety
Ampicillin and cloxacillin are excreted in breast milk. Caution should be exercised when administered to a nursing woman. Consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdose may cause gastrointestinal symptoms such as nausea, vomiting, and diarrhea. In severe cases, neuromuscular excitability and seizures may occur, especially in patients with renal impairment. Treatment is symptomatic and supportive. Hemodialysis may be considered to remove ampicillin from the blood in severe cases. Contact a poison control center or emergency room immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Before taking this medicine, inform your doctor if you are allergic to penicillins, cephalosporins, or any other antibiotics. Provide a complete list of all medications, supplements, and herbal products you are taking, as this medicine can interact with many drugs. Do not use this medicine to treat viral infections like colds or flu. Take this medicine exactly as prescribed, at evenly spaced intervals, and complete the full course even if you feel better. Do not share this medicine with others. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before use. This medicine may reduce the effectiveness of oral contraceptives; use additional birth control methods. Avoid alcohol while taking this medicine as it may worsen gastrointestinal side effects. If you experience severe diarrhea, rash, or difficulty breathing, stop the medicine and seek immediate medical help. Keep this medicine out of reach of children and store it as directed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced renal function, which may require dose adjustment. Monitor renal function closely.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is generally considered safe in pregnancy but should be used only if clearly needed.
🏥 Post-Surgery Considerations
This medicine may be prescribed to prevent or treat surgical site infections. Follow your surgeon's instructions carefully.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with other medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
If you experience dizziness or fatigue, avoid strenuous exercise until you feel better. Light activity is generally safe.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people. If affected, avoid driving or operating heavy machinery until you know how it affects you.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance and disruption of normal flora, causing fungal infections. Regular monitoring of renal and hepatic function is advised for prolonged therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Alternative antibiotic combination with broader spectrum.
Evidence: Well-establishedAlternative for skin infections in penicillin-allergic patients.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines, such as the typhoid vaccine. Avoid concurrent use.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying antibiotics.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 2-3 days, but it is important to complete the full course as prescribed.
A: It is best taken on an empty stomach, but if it causes stomach upset, you can take it with food.
A: Take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
🤔 Common Patient Concerns
🔄 Substitutes for broadiclox 125mg/125mg injection
View AllAlternative brands with exact same active ingredient:
-
dynacil plus 125mg/125mg injectionHindustan Antibiotics Ltd ₹7.00 9.2% CHEAPER
-
duoclox 125 mg/125 mg injectionFDC Ltd ₹7.85 1.8% COSTLIER
-
baxin 125 mg/125 mg injectionHetero Drugs Ltd ₹8.18 6.1% COSTLIER
-
Tobiotic 125mg/125mg InjectionNeon Laboratories Ltd ₹8.45 9.6% COSTLIER
-
climpen 125mg/125mg injectionMacleods Pharmaceuticals Pvt Ltd ₹8.90 15.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure viral infections like the common cold.
Fact: Antibiotics only work against bacteria. They are ineffective against viruses. - Myth: You can stop taking antibiotics once you feel better.
Fact: You must complete the full course to prevent recurrence and resistance. - Myth: Antibiotics are safe to share with others.
Fact: Antibiotics are prescribed for specific infections and should never be shared.
🔄 Alternative Options
Generic Alternatives
- Ampicillin + Cloxacillin generic capsules
Brand Alternatives
- Ampoxin 250 capsule