Brintellix 10mg Tablet (Vortioxetine): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- New or worsening thoughts of suicide or self-harm.
- Agitation, hallucinations, rapid heart rate, high blood pressure, or muscle stiffness (possible serotonin syndrome).
- Unusual bleeding or bruising, such as blood in stool or vomit.
- Severe eye pain, blurred vision, or seeing halos around lights (possible angle-closure glaucoma).
- Confusion, weakness, headache, or seizures (possible hyponatremia).
- Swelling of the face, lips, tongue, or throat, or difficulty breathing (severe allergic reaction).
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain (possible liver problems).
If experiencing severe symptoms, call emergency services immediately.
What is brintellix 10mg tablet used for?
This medicine is a prescription antidepressant containing vortioxetine, used to treat major depressive disorder in adults. It works by enhancing serotonin activity in the brain and is taken orally once daily. Common side effects include nausea, constipation, and dizziness. It carries a boxed warning for increased suicidal thoughts in young adults.
- Generic Name: Vortioxetine (10mg)
- Manufacturer: Lundbeck India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 brintellix 10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा वोर्टिओक्सेटीन नामक सक्रिय तत्व युक्त एक प्रिस्क्रिप्शन एंटीडिप्रेसेंट है, जिसका उपयोग वयस्कों में प्रमुख अवसादग्रस्तता विकार (मेजर डिप्रेसिव डिसऑर्डर) के इलाज के लिए किया जाता है। यह मस्तिष्क में सेरोटोनिन के स्तर को बढ़ाकर मूड, ऊर्जा और भावनात्मक संतुलन को बेहतर बनाने में मदद करती है। यह दवा 10 मिलीग्राम की गोली के रूप में उपलब्ध है और इसे दिन में एक बार मौखिक रूप से लिया जाता है। यह अवसाद के लक्षणों जैसे उदासी, निराशा, थकान और रुचि की कमी को कम करने में सहायक है। यह दवा केवल डॉक्टर के परामर्श से ही लेनी चाहिए और इसे अचानक बंद नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, कब्ज, दस्त, सूखा मुँह, चक्कर आना, सिरदर्द, खुजली, असामान्य सपने और अत्यधिक पसीना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ हफ्तों में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन सेरोटोनिन सिंड्रोम, रक्तस्राव का खतरा, हाइपोनेट्रेमिया (सोडियम की कमी), और आंखों में दर्द या धुंधली दृष्टि जैसी समस्याएं हो सकती हैं। यदि आपको कोई भी असामान्य लक्षण महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों, विशेषकर यकृत या गुर्दे की बीमारी, रक्तस्राव विकार, निम्न सोडियम स्तर, दौरे या ग्लूकोमा के बारे में बताएं। अपने डॉक्टर को अपनी सभी दवाओं, जड़ी-बूटियों और सप्लीमेंट्स के बारे में भी बताएं। इस दवा को लेते समय शराब का सेवन न करें। जब तक आपको पता न चले कि यह दवा आपको कैसे प्रभावित करती है, तब तक वाहन चलाने या भारी मशीनरी चलाने से बचें। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं, तो अपने डॉक्टर से परामर्श करें। इस दवा को अचानक बंद न करें, क्योंकि इससे withdrawal के लक्षण हो सकते हैं। हमेशा अपने डॉक्टर के निर्देशों का पालन करें।
💊 brintellix 10mg tablet Uses & Benefits
- [{"condition":"Major Depressive Disorder (MDD)","description":"This medicine is approved for the treatment of major depressive disorder in adults.
- It helps to improve mood, reduce feelings of sadness and hopelessness, and restore interest in daily activities.","evidence":"Well-established"},{"condition":"Generalized Anxiety Disorder (GAD)","description":"This medicine may be used off-label to treat generalized anxiety disorder, although it is not approved for this indication in all countries.
- Some studies suggest it can reduce anxiety symptoms.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Generalized Anxiety Disorder","description":"Sometimes prescribed off-label for persistent excessive worry and anxiety, but evidence is not as strong as for depression.","evidence":"Moderate"},{"condition":"Neuropathic Pain","description":"Occasionally used off-label for nerve pain, but evidence is limited and it is not a first-line treatment.","evidence":"Limited"}]
Primary treatment for: Major Depressive Disorder
Also treats: Generalized Anxiety Disorder, Neuropathic Pain
📋 Drug Information
| Generic Name(s) | Vortioxetine (10mg) |
| Brand Name | brintellix 10mg tablet |
| Manufacturer | Lundbeck India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Serotonin modulator and stimulator |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C (59°F to 86°F). Keep it in its original container, tightly closed, and away from moisture, heat, and direct light. Do not store it in the bathroom. Keep out of reach of children and pets. |
| Shelf Life | The shelf life of this medicine is typically 24 to 36 months from the date of manufacture. Check the expiration date on the packaging before use. Do not use if expired. |
| WHO Guideline | The World Health Organization (WHO) recommends antidepressants like this medicine as part of a comprehensive treatment plan for moderate to severe depression. However, specific recommendations for vortioxetine are not explicitly stated in WHO guidelines. Treatment should be individualized. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) does not have specific guidelines for vortioxetine. In general, ICMR recommends antidepressant therapy for moderate to severe depression, with regular monitoring and follow-up. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by modulating the activity of serotonin in the brain. It is a serotonin modulator and stimulator that acts as an antagonist at certain serotonin receptors (5-HT3, 5-HT7, and 5-HT1D) and as an agonist at others (5-HT1A), while also inhibiting the serotonin transporter (SERT). This multi-modal action increases serotonin levels in the synaptic cleft and enhances serotonergic neurotransmission, which is thought to underlie its antidepressant effects. Unlike selective serotonin reuptake inhibitors (SSRIs), this medicine also directly modulates receptor activity, which may contribute to its efficacy and tolerability profile.
Mechanism Steps
💡 How to Take brintellix 10mg tablet
Strength: This medicine is available as an immediate-release tablet in strengths of 5 mg, 10 mg, and 20 mg. The 10 mg strength is commonly prescribed.
Dosage Information
| Adult Dosage | The recommended starting dose of this medicine for major depressive disorder is 10 mg taken orally once daily. Depending on your response and tolerability, your doctor may increase the dose to a maximum of 20 mg once daily. For elderly patients or those with certain medical conditions, a lower starting dose of 5 mg once daily may be recommended. This medicine can be taken with or without food. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and other medications you are taking. Do not adjust your dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (65 years and older) may be more sensitive to the side effects of this medicine, especially hyponatremia and dizziness. A lower starting dose of 5 mg once daily is often recommended. Dose adjustments should be made cautiously based on tolerability and response. Regular monitoring of sodium levels and renal function is advised. |
| Renal Impairment | No dose adjustment is required for patients with mild to moderate renal impairment. For patients with severe renal impairment, this medicine should be used with caution, as there is limited data. Consult your doctor for personalized dosing. |
| Hepatic Impairment | For patients with mild to moderate hepatic impairment, no dose adjustment is typically needed. However, for patients with severe hepatic impairment, this medicine is not recommended. Consult your doctor for personalized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine is 20 mg once daily. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of brintellix 10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| SSRIs/SNRIs | Major | |
| Warfarin | Major | |
| NSAIDs | Major | |
| Aspirin | Major | |
| Bupropion | Moderate | |
| Fluoxetine | Moderate | |
| Ketoconazole | Moderate | |
| Rifampin | Moderate | |
| Alcohol | Moderate |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Other serotonergic drugs (e.g., SSRIs, SNRIs, triptans, tramadol, linezolid)
- Anticoagulants (e.g., warfarin) and antiplatelet drugs (e.g., aspirin, clopidogrel)
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Strong CYP2D6 inhibitors (e.g., bupropion, fluoxetine, paroxetine, quinidine)
- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- CYP2D6 substrates (e.g., metoprolol, flecainide, propafenone)
- Alcohol
⚡ Moderate Interactions
- CYP2D6 inhibitors (moderate)
- CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin)
- Diuretics
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase drowsiness, dizziness, and impair judgment. It may also worsen depression and anxiety symptoms. If you choose to drink alcohol, do so in moderation and consult your doctor first.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to vortioxetine or any component of the formulation.","Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI.","Use in children and adolescents under 18 years of age (safety and efficacy not established).","Severe hepatic impairment."]
⚠️ Warnings & Precautions
["Antidepressants may increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults under 25 years of age. Close monitoring is required.","Serotonin syndrome may occur, especially when used with other serotonergic drugs. Symptoms include agitation, hallucinations, rapid heart rate, and muscle stiffness.","Increased risk of bleeding, particularly when used with NSAIDs, aspirin, or anticoagulants.","Hyponatremia may occur, especially in elderly patients or those taking diuretics. Monitor sodium levels.","Angle-closure glaucoma may occur. Patients with narrow-angle glaucoma should be cautious.","Do not stop this medicine abruptly, as it can cause withdrawal symptoms. Taper gradually under medical supervision.","Use with caution in patients with a history of seizures, bipolar disorder, or mania.","May impair cognitive and motor function. Avoid driving or operating machinery until you know how it affects you."]
🤱 Lactation Safety
This medicine is excreted in human breast milk in small amounts. There is limited information on its effects on breastfed infants. The benefits of breastfeeding should be weighed against the potential risks to the infant and the mother's need for the medication. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
There is limited information on overdose with this medicine. In case of suspected overdose, seek immediate medical attention. Treatment should be symptomatic and supportive. Monitor vital signs, cardiac rhythm, and respiratory function. There is no specific antidote. Gastric lavage may be considered if the overdose is recent and the patient is stable. Contact a poison control center for the most current guidance.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure what to do, contact your doctor or pharmacist.
Additional Safety Advice
Before starting this medicine, tell your doctor about all your medical conditions, especially if you have liver or kidney disease, bleeding disorders, low sodium levels, or a history of seizures or glaucoma. Inform your doctor about all prescription, over-the-counter, and herbal medicines you are taking, as this medicine can interact with many other drugs. Do not drink alcohol while taking this medicine, as it can worsen side effects such as dizziness and drowsiness. Avoid driving or operating heavy machinery until you know how this medicine affects you. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits with your doctor before using this medicine. Do not stop taking this medicine suddenly, as it can cause withdrawal symptoms such as anxiety, irritability, and insomnia. Always follow your doctor's instructions for tapering off the medication. Keep this medicine out of reach of children and store it at room temperature away from moisture and heat. If you miss a dose, take it as soon as you remember, but skip it if it is almost time for your next dose. Never double the dose to make up for a missed one. If you experience any serious side effects such as seizures, difficulty breathing, or severe allergic reactions, seek emergency medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, particularly hyponatremia, dizziness, and falls. A lower starting dose of 5 mg once daily is often recommended. Regular monitoring of sodium levels, renal function, and mood is advised. Caregivers should be vigilant for signs of confusion or weakness.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not fully established. Your doctor will weigh the benefits of treating depression against potential risks to the baby. Do not stop or start any medication without medical advice.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with certain anesthetic agents and increase the risk of bleeding. Your doctor may advise you to temporarily stop the medicine before surgery, but never do so without medical guidance.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may increase the risk of bleeding during dental work, especially if you are also taking NSAIDs or blood thinners. Your dentist may take extra precautions to control bleeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally safe and beneficial while taking this medicine. However, if you experience dizziness or fatigue, start with light activities and gradually increase intensity. Stay hydrated and avoid overexertion. Consult your doctor before starting a new exercise regimen, especially if you have heart or lung conditions.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or difficulty concentrating, especially during the first few weeks. Avoid driving or operating heavy machinery until you know how it affects you. If your job requires mental alertness, discuss with your doctor about timing your dose to minimize impact. Most people are able to continue their normal work activities after the initial adjustment period.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as serotonin syndrome, severe allergic reactions, or suicidal thoughts, seek immediate medical attention. Your doctor may decide to stop the medication or adjust the dose based on your response and side effects. Always taper gradually to avoid withdrawal symptoms.
📅 Long-Term Use Effects
Long-term use of this medicine is generally well-tolerated. However, regular monitoring for mood changes, suicidal thoughts, and side effects is important. Some patients may experience sexual dysfunction, weight changes, or sleep disturbances. Periodic evaluation of liver and kidney function may be advised. Do not stop the medication without consulting your doctor, as abrupt discontinuation can lead to withdrawal symptoms and relapse of depression.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A type of talk therapy that helps change negative thought patterns and behaviors associated with depression.
Evidence: Well-establishedPhysical activity can boost mood and reduce symptoms of depression.
Evidence: Well-establishedPractices that promote relaxation and emotional balance.
Evidence: ModerateExposure to bright light can help with seasonal affective disorder.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a live vaccine, inform your doctor, as antidepressants may affect immune response in rare cases. Generally, you can continue this medicine while receiving vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C (59°F to 86°F).
❌ DON'T
Do not refrigerate unless specified.
✅ DO
Keep in the original container, tightly closed.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of reach of children and pets.
❌ DON'T
Do not use after the expiration date.
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or exposure to extreme temperatures. If crossing time zones, continue taking your dose at the same interval as prescribed; you may need to adjust the timing gradually. Store it at room temperature and avoid leaving it in a hot car. Check the customs regulations of your destination country regarding prescription medications. It is advisable to carry enough supply for your entire trip and a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start to notice some improvement in mood and energy within 1 to 2 weeks, but full therapeutic effects typically take 6 to 8 weeks. It is important to continue taking the medicine as prescribed and not to stop early.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: It is best to avoid alcohol while taking this medicine, as it can increase drowsiness, dizziness, and impair judgment. It may also worsen depression and anxiety symptoms.
A: The safety of this medicine during pregnancy is not fully established. Untreated depression can pose risks to both mother and baby. Consult your doctor to weigh the benefits and risks before using this medicine.
A: No, you should not stop taking this medicine abruptly as it can cause withdrawal symptoms such as anxiety, irritability, and insomnia. Always consult your doctor for a gradual tapering plan.
A: Clinical trials have not shown significant weight gain with this medicine. Some patients may even experience weight loss. However, individual responses can vary.
A: Some antidepressants can cause sexual side effects, but this medicine has a lower incidence compared to SSRIs. If you experience any changes, discuss with your doctor.
A: Taking this medicine with other antidepressants, especially MAOIs, can increase the risk of serotonin syndrome. Always inform your doctor about all medications you are taking.
🤔 Common Patient Concerns
🔄 Substitutes for brintellix 10mg tablet
View AllAlternative brands with exact same active ingredient:
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vdep 10mg tabletCyrus Remedies ₹156.56 77.6% CHEAPER
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vortiray 10mg tabletIcon Life Sciences ₹178.10 74.5% CHEAPER
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vortidif 10mg tabletSun Pharmaceutical Industries Ltd ₹178.13 74.5% CHEAPER
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lupivor 10mg tabletLupin Ltd ₹181.50 74% CHEAPER
-
vormind 10mg tabletMSN Laboratories ₹190.27 72.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a habit-forming drug.
Fact: This medicine is not considered habit-forming or addictive. It does not produce a high or craving. - Myth: This medicine works immediately.
Fact: It may take 2 to 4 weeks to notice improvement, and 6 to 8 weeks for full effects. - Myth: You can stop taking this medicine once you feel better.
Fact: Stopping abruptly can cause withdrawal symptoms and relapse. Always taper under medical supervision. - Myth: This medicine is safe to take with any other medication.
Fact: It can interact with many drugs, including MAOIs, NSAIDs, and blood thinners. Always consult your doctor. - Myth: This medicine causes weight gain.
Fact: Clinical trials have not shown significant weight gain with this medicine; some patients may even lose weight.
🔄 Alternative Options
Generic Alternatives
- Vortioxetine 10 mg tablet
Brand Alternatives
- Brintellix 10 mg tablet
- Trintellix 10 mg tablet