Adiflam Plus Suspension: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
- Persistent vomiting
- Confusion or extreme drowsiness
If experiencing severe symptoms, call emergency services immediately.
What is bren plus 100 mg/162.5 mg suspension used for?
This medicine is a combination oral suspension of ibuprofen and paracetamol used for short-term relief of fever and mild to moderate pain in children and adults. It works by reducing inflammation, pain, and fever through two different mechanisms. It should be used only as recommended by a doctor and not for more than a few days without medical advice.
- Generic Name: Ibuprofen + Paracetamol
- Manufacturer: Kopran Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 bren plus 100 mg/162.5 mg suspension के बारे में (Hindi Summary)
उपयोग: यह दवा इबुप्रोफेन और पैरासिटामोल का संयोजन है, जिसका उपयोग बुखार और हल्के से मध्यम दर्द के अल्पकालिक उपचार के लिए किया जाता है। यह बच्चों और बड़ों दोनों के लिए उपलब्ध है। यह दवा सूजन को कम करने, दर्द को शांत करने और बुखार को उतारने में मदद करती है। इसका उपयोग आमतौर पर वायरल संक्रमण, टीकाकरण के बाद बुखार, दांत निकलने के दर्द, कान के दर्द, गले के दर्द और मामूली चोटों में किया जाता है। यह दवा केवल डॉक्टर की सलाह पर ही दी जानी चाहिए और इसे खाली पेट नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, पेट में दर्द, और दस्त शामिल हैं। कुछ बच्चों को नींद या चिड़चिड़ापन महसूस हो सकता है। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, किडनी की समस्या, लिवर की क्षति, और एलर्जी प्रतिक्रियाएं शामिल हैं। अगर आपको काला मल, उल्टी में खून, पेट में तेज दर्द, आंखों या त्वचा का पीलापन, या पेशाब कम आना जैसे लक्षण दिखें, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को देने से पहले बोतल को अच्छी तरह हिलाएं। हमेशा दवा के साथ दी गई मापने वाली कप या सिरिंज का उपयोग करें, चम्मच का नहीं। इसे भोजन या दूध के साथ दें ताकि पेट में जलन न हो। 3 महीने से छोटे बच्चों को बिना डॉक्टर की सलाह के यह दवा न दें। बच्चों में 3 दिन से ज्यादा और बड़ों में 5 दिन से ज्यादा इस दवा का उपयोग न करें। इस दवा को अन्य पैरासिटामोल युक्त दवाओं के साथ न दें। इसे बच्चों की पहुंच से दूर रखें।
💊 bren plus 100 mg/162.5 mg suspension Uses & Benefits
[{"condition":"Fever with mild to moderate pain","description":"Used for short-term relief of fever and pain associated with viral infections, colds, and flu-like illnesses.","evidence":"Well-established"},{"condition":"Post-immunization fever and pain","description":"Helps reduce fever and soreness at the injection site after childhood vaccinations.","evidence":"Well-established"},{"condition":"Teething pain","description":"Provides temporary relief from gum discomfort and fever during teething in infants and toddlers.","evidence":"Commonly used"},{"condition":"Ear pain (otalgia)","description":"Used as a short-term measure for ear pain while awaiting medical evaluation.","evidence":"Commonly used"},{"condition":"Sore throat","description":"Relieves throat pain and reduces fever associated with pharyngitis or tonsillitis.","evidence":"Commonly used"},{"condition":"Minor injuries and sprains","description":"Reduces pain and inflammation" class="semantic-link" title="Medicines for swelling">swelling from minor musculoskeletal injuries.","evidence":"Commonly used"}]
Off-label uses: [{"condition":"Migraine attacks in children","description":"Sometimes used off-label for acute migraine pain when other treatments are not suitable.","evidence":"Limited"},{"condition":"Post-operative dental pain","description":"Occasionally used off-label for short-term pain relief after dental procedures.","evidence":"Limited"}]
Primary treatment for: Fever with mild to moderate pain
Also treats: Viral upper respiratory tract infection, Post-immunization fever, Teething discomfort, Ear pain, Sore throat, Minor musculoskeletal injuries
📋 Drug Information
| Generic Name(s) | Ibuprofen + Paracetamol |
| Brand Name | Adiflam Plus 400 mg/500 mg Tablet |
| Manufacturer | Kopran Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from direct sunlight and moisture. Do not freeze. Keep the bottle tightly closed and out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two pain-relieving and fever-reducing ingredients with different mechanisms. Ibuprofen is a non-steroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase-1 and cyclooxygenase-2 enzymes, reducing the production of prostaglandins that cause inflammation, pain, and fever. Paracetamol acts mainly in the central nervous system, where it reduces prostaglandin synthesis and may also affect pain signaling pathways, producing analgesia and fever reduction without significant anti-inflammatory action. Together, they provide broader symptom relief than either ingredient alone.
Mechanism Steps
💡 How to Take bren plus 100 mg/162.5 mg suspension
Strength: Each 5 mL of oral suspension contains 100 mg of ibuprofen and 162.5 mg of paracetamol.
Dosage Information
| Adult Dosage | For adults, the usual dose of this suspension is 10 mL to 20 mL every 6 to 8 hours as needed for pain and fever. Do not exceed 4 doses in 24 hours. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Adults with kidney or liver problems may need a lower dose or a different medicine. Always use the measuring cup provided with the product. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is not recommended for children under 3 months of age unless specifically prescribed by a doctor. For older children, the dose is usually based on weight and should be determined by a pediatrician. Do not use household spoons for measuring. |
| Elderly Dosage | Elderly patients above 65 years of age may be more sensitive to the side effects of this medicine, especially stomach bleeding, kidney problems, and heart effects. Use the lowest effective dose for the shortest possible time. A doctor should assess kidney and liver function before recommending this medicine. |
| Renal Impairment | Use with caution in patients with kidney disease. Ibuprofen can worsen kidney function. A doctor may recommend a lower dose, less frequent dosing, or an alternative medicine. This medicine is contraindicated in severe kidney disease. |
| Hepatic Impairment | Use with caution in patients with liver disease. Paracetamol can cause liver injury, especially in higher doses or with alcohol use. A doctor may recommend a lower dose or an alternative medicine. This medicine is contraindicated in severe liver disease. |
| Maximum Daily Dose | The maximum daily dose for adults is 80 mL of this suspension in 24 hours, which provides 1600 mg of ibuprofen and 2600 mg of paracetamol. Do not exceed this dose. For children, the maximum daily dose must be determined by a pediatrician based on weight. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of bren plus 100 mg/162.5 mg suspension
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Lithium | Moderate | |
| Antihypertensives | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Warfarin
- Other paracetamol-containing products
- Methotrexate
- ACE inhibitors and angiotensin receptor blockers
- Diuretics
⚡ Moderate Interactions
- Corticosteroids
- Selective serotonin reuptake inhibitors
- Lithium
- Antihypertensives
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver injury from paracetamol and raises the chance of stomach bleeding from ibuprofen. If you drink alcohol regularly, talk to your doctor before using this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to ibuprofen, paracetamol, or any other ingredient","Active stomach ulcer or gastrointestinal bleeding","Severe kidney disease","Severe liver disease","Aspirin-sensitive asthma or history of asthma triggered by NSAIDs","Heart failure or recent heart attack","Children under 3 months of age unless prescribed by a doctor","Use of other paracetamol-containing products"]
⚠️ Warnings & Precautions
["Do not exceed the recommended dose of this medicine.","Do not use for more than 3 days in children or 5 days in adults without medical advice.","Avoid alcohol while taking this medicine.","Use with caution in people with asthma, kidney disease, liver disease, or heart disease.","Do not use together with other NSAIDs or paracetamol-containing products.","Stop the medicine and seek medical help if you notice signs of bleeding, liver problems, or allergic reactions.","Keep out of reach of children.","Shake well before use and measure accurately."]
🤱 Lactation Safety
Ibuprofen and paracetamol are generally considered compatible with breastfeeding in usual doses. However, this combination product should only be used while breastfeeding if recommended by a doctor. Monitor the infant for any unusual drowsiness, rash, or feeding problems.
💊 Overdose Management
Overdose of this medicine can cause serious liver injury from paracetamol and kidney or stomach problems from ibuprofen. Symptoms of overdose may include nausea, vomiting, abdominal pain, drowsiness, and confusion. If you suspect an overdose, seek emergency medical care immediately. Do not wait for symptoms to appear. Treatment may include activated charcoal, acetylcysteine for paracetamol toxicity, and supportive care. Carry the medicine bottle to the hospital so the doctor knows exactly what was taken.
⏰ Missed Dose
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose to make up for a missed one.
Additional Safety Advice
Always shake the bottle well before measuring this medicine. Use the measuring cup or oral syringe provided with the product, not a household spoon, to ensure the correct dose. Give this medicine with food or milk to reduce stomach upset. Do not give this medicine to children under 3 months of age unless a doctor specifically prescribes it. Do not use this medicine for more than 3 days in children or 5 days in adults without consulting a doctor. Never combine this medicine with other products that contain paracetamol or ibuprofen. Avoid giving this medicine to anyone who has a stomach ulcer, severe kidney or liver disease, or a history of asthma triggered by aspirin or similar pain relievers. Keep this medicine out of reach of children and store it at room temperature, away from direct sunlight. If a dose is missed, give it as soon as you remember, but do not double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of stomach bleeding, kidney problems, and heart effects from this medicine. Use the lowest effective dose for the shortest duration. A doctor should assess kidney and liver function before use. Avoid long-term use unless supervised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. Ibuprofen may affect ovulation and should be avoided around conception. Paracetamol is generally preferred, but always seek medical advice.
🏥 Post-Surgery Considerations
This medicine may be used for short-term pain relief after some surgeries, but it should only be used if recommended by your surgeon. Ibuprofen can increase bleeding risk, so it may be avoided after certain procedures. Follow your surgeon's instructions carefully.
🦷 Dental Procedures
This medicine can be used for short-term pain relief after dental procedures, but it should not replace proper dental care. Inform your dentist if you are taking this medicine, especially if you have a history of stomach ulcers or bleeding disorders.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you can continue light activities if you feel well. Avoid strenuous exercise or heavy lifting if you have pain or fever. Listen to your body and rest when needed. If you experience dizziness or drowsiness, avoid driving or operating machinery.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their daily activities, but rest is recommended if you have fever or pain.
🛑 When to Stop This Medicine
Stop taking this medicine and consult a doctor if your symptoms do not improve within 3 days for children or 5 days for adults, or if they worsen. Also stop and seek immediate medical help if you experience signs of bleeding, liver problems, kidney problems, or allergic reactions. Do not stop any prescribed medicine without talking to your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of stomach ulcers, gastrointestinal bleeding, kidney problems, and cardiovascular events. Paracetamol can cause liver injury if used in high doses over time. This medicine is not recommended for long-term use without medical supervision. Regular monitoring of liver and kidney function may be needed if prolonged use is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help manage chronic pain and improve mobility without relying solely on medicines.
Evidence: Well-establishedApplying a cold pack to the affected area can reduce swelling and numb pain.
Evidence: Commonly usedAdequate rest and fluids help the body recover from fever and infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine can be used to reduce fever and pain after vaccinations. However, it should not be given routinely before vaccination unless advised by a doctor, as it may affect the immune response. Consult your doctor for specific guidance.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container with the cap tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label intact. Bring a copy of the prescription or a doctor's note, especially for international travel. Store the bottle at room temperature and protect it from extreme heat or cold. If traveling across time zones, continue with the usual dosing schedule as needed for symptoms, but do not exceed the maximum daily dose. Check customs regulations for carrying medicines into your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 to 60 minutes after taking it. The peak effect is reached in about 1 to 2 hours.
A: It is usually taken every 6 to 8 hours as needed, but do not exceed 4 doses in 24 hours. Follow your doctor's instructions.
A: This medicine can be given to children older than 3 months only if prescribed by a doctor. The dose depends on the child's weight.
A: Common side effects include nausea, vomiting, and stomach discomfort. Serious side effects include stomach bleeding, liver injury, and kidney problems. Seek medical help if you notice any serious symptoms.
A: Do not take this medicine with other paracetamol-containing products or NSAIDs without consulting a doctor. It can interact with blood thinners, methotrexate, and blood pressure medicines.
A: Ibuprofen should be avoided in the third trimester. Paracetamol is generally considered safer. Consult your doctor before using this medicine during pregnancy.
🤔 Common Patient Concerns
🔄 Substitutes for bren plus 100 mg/162.5 mg suspension
View AllAlternative brands with exact same active ingredient:
-
ibu p 100 mg/162.5 mg suspensionIndoco Remedies Ltd ₹10.66 14.5% CHEAPER
-
dolofen suspensionOyster Labs Ltd ₹12.00 3.8% CHEAPER
-
pyremol ib 100 mg/162.5 mg suspensionAlembic Pharmaceuticals Ltd ₹14.16 13.6% COSTLIER
-
gexophen oral suspensionGerman Remedies ₹15.09 21% COSTLIER
-
children's combipain suspension orangeScott Edil Pharmacia Ltd ₹15.19 21.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe for everyone.
Fact: This medicine is not safe for people with stomach ulcers, severe kidney or liver disease, or aspirin-sensitive asthma. It should only be used when appropriate. - Myth: More medicine means faster relief.
Fact: Taking more than the recommended dose can cause serious liver and kidney damage. Always follow the recommended dose. - Myth: This medicine can be taken with other paracetamol products.
Fact: Combining this medicine with other paracetamol-containing products can lead to paracetamol overdose and liver injury. - Myth: This medicine is safe to take for weeks without doctor supervision.
Fact: This medicine is intended for short-term use. Long-term use requires medical supervision and monitoring.
🔄 Alternative Options
Generic Alternatives
- Ibuprofen 100 mg and Paracetamol 162.5 mg oral suspension
- Ibuprofen and Paracetamol combination oral suspension
Brand Alternatives
- Adiflam Plus Suspension