Blispam-Plus Tablet - Uses, Price, Side Effects, and More
What is blispam-plus tablet used for?
Blispam-Plus Tablet is a combination of Clonazepam (0.5mg) and Escitalopram (10mg) used to treat anxiety disorders and depression. Clonazepam works by enhancing GABA activity to reduce anxiety and promote calmness, while Escitalopram increases serotonin levels to improve mood. It is typically taken once or twice daily as prescribed by a doctor.
- Generic Name: Clonazepam + Escitalopram
- Manufacturer: Daikon Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ blispam-plus tablet Uses & Benefits
Generalized anxiety disorder, panic disorder, depression with anxiety
Off-label uses: Social anxiety disorder, post-traumatic stress disorder, insomnia
๐ Drug Information
| Generic Name(s) | Clonazepam + Escitalopram |
| Brand Name | Asiclopam Tablet |
| Manufacturer | Daikon Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Benzodiazepine + SSRI |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Clonazepam: Enhances GABA-A receptor activity; Escitalopram: Inhibits serotonin reuptake
Mechanism Steps
๐ก How to Take blispam-plus tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of blispam-plus tablet
โ Common Side Effects
- Drowsiness
- Dizziness
- Fatigue
- Nausea
- Dry mouth
- Constipation
๐จ Serious Side Effects
- Respiratory depression
- Serotonin syndrome
- QT prolongation
- Suicidal thoughts
- Seizures
โ ๏ธ Rare Side Effects
- Blood dyscrasias
- Hepatotoxicity
- Stevens-Johnson syndrome
- Paradoxical reactions
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | Increased CNS depression and sedation |
| MAOIs | Major | Risk of serotonin syndrome |
| Warfarin | Moderate | Altered anticoagulant effect |
| Cimetidine | Moderate | Increased clonazepam levels |
๐จ Major Interactions
- MAOIs
- CYP2C19 inhibitors
- CYP3A4 inhibitors
- Other CNS depressants
โก Moderate Interactions
- SSRIs/SNRIs
- Antipsychotics
- Lithium
- Warfarin
โน๏ธ Minor Interactions
- Cimetidine
- Oral contraceptives
- Grapefruit juice
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase escitalopram levels; food delays absorption
๐ท Alcohol Interaction
Avoid alcohol; increased CNS depression
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, severe hepatic impairment, narrow-angle glaucoma, MAOI use, respiratory depression
๐ Monitoring Parameters
Liver function, renal function, ECG, suicidal ideation, sedation level
๐คฑ Lactation Safety
Not recommended; both drugs excreted in breast milk
๐ Overdose Management
Supportive care, flumazenil for clonazepam overdose, ECG monitoring for QT prolongation
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double