bisomax 5h tablet - Bisoprolol (5mg) + Hydrochlorothiazide (6.25mg) medicine

Bisomax 5H Tablet - Uses, Price, Side Effects

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🏭 Johnlee Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

What is bisomax 5h tablet used for?

Bisomax 5H Tablet is a combination of Bisoprolol (a beta-blocker) and Hydrochlorothiazide (a diuretic) used to treat high blood pressure (hypertension). Bisoprolol works by slowing the heart rate and reducing the workload on the heart, while Hydrochlorothiazide helps remove excess fluid and salt from the body, lowering blood pressure. It is typically taken once daily in the morning.

  • Generic Name: Bisoprolol + Hydrochlorothiazide
  • Manufacturer: Johnlee Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 bisomax 5h tablet Uses & Benefits

Hypertension

Off-label uses: Heart failure (Bisoprolol alone), edema (Hydrochlorothiazide alone)

📋 Drug Information

Generic Name(s)Bisoprolol + Hydrochlorothiazide
Brand NameBisobis H
ManufacturerJohnlee Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassBeta-blocker + Thiazide diuretic
Route of AdministrationOral
StorageStore at 20-25°C, protect from light and moisture
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionBisoprolol: well absorbed orally; Hydrochlorothiazide: 65-75% absorbed
DistributionBisoprolol: Vd ~3.5 L/kg; Hydrochlorothiazide: crosses placenta, enters breast milk
Protein BindingBisoprolol: ~30%; Hydrochlorothiazide: ~40-68%
MetabolismBisoprolol: hepatic via CYP2D6; Hydrochlorothiazide: minimal hepatic
Half-LifeBisoprolol: 10-12 hours; Hydrochlorothiazide: 6-15 hours
ExcretionBisoprolol: 50% renal unchanged, rest as metabolites; Hydrochlorothiazide: >95% renal
BioavailabilityBisoprolol: ~90%; Hydrochlorothiazide: ~65-75%
Onset of ActionBisoprolol: 1-2 hours; Hydrochlorothiazide: 2 hours
Peak Plasma TimeBisoprolol: 2-4 hours; Hydrochlorothiazide: 4 hours
Duration of ActionBisoprolol: 24 hours; Hydrochlorothiazide: 6-12 hours

How It Works

Bisoprolol: selective beta1-blocker reducing heart rate and contractility; Hydrochlorothiazide: inhibits Na+/Cl- reabsorption in distal tubule, reducing plasma volume

Mechanism Steps

1Bisoprolol selectively blocks beta-1 adrenergic receptors in the heart, reducing sympathetic tone, decreasing heart rate and contractility, leading to reduced cardiac output and blood pressure.
2Hydrochlorothiazide inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, increasing excretion of sodium, chloride, and water, reducing plasma volume and blood pressure.
3Combination results in additive antihypertensive effect with lower doses of each component.

💡 How to Take bisomax 5h tablet

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

⚠️ Side Effects of bisomax 5h tablet

✅ Common Side Effects

Dizziness
Fatigue
Headache
Hypokalemia
Hyperuricemia
Increased blood glucose
Orthostatic hypotension

🚨 Serious Side Effects

Bradycardia
Heart block
Bronchospasm
Severe hypotension
Electrolyte imbalance
Acute renal failure

⚠️ Rare Side Effects

Thrombocytopenia
Pancreatitis
Photosensitivity
Systemic lupus erythematosus
Stevens-Johnson syndrome

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Lithium Moderate Increased risk of lithium toxicity due to thiazide-induced sodium depletion
NSAIDs Moderate Reduced antihypertensive effect and increased risk of renal impairment
Digoxin Moderate Increased risk of digoxin toxicity due to hypokalemia
Insulin Moderate May alter glycemic control; monitor blood sugar

🚨 Major Interactions

  • Other antihypertensives
  • Digitalis glycosides
  • Lithium
  • NSAIDs
  • Corticosteroids
  • MAOIs

⚡ Moderate Interactions

  • Antidiabetic agents
  • Calcium channel blockers
  • Clonidine
  • Reserpine
  • Cholestyramine
  • Colestipol

🍷 Alcohol Interaction

May potentiate orthostatic hypotension

🛡️ Safety & Warnings

🚫 Contraindications

Sinus bradycardia, heart block, cardiogenic shock, severe asthma, anuria, hypersensitivity to sulfonamides

🤱 Lactation Safety

Contraindicated; both drugs excreted in breast milk

💊 Overdose Management

Gastric lavage, activated charcoal, symptomatic treatment; for bradycardia: atropine; for hypotension: IV fluids, vasopressors

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose

🔄 Substitutes for bisomax 5h tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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